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Stem Cells and Cancer Stem Cells

  • Chapter
Breast Cancer Stem Cells & Therapy Resistance

Part of the book series: SpringerBriefs in Stem Cells ((BRIEFSSTEM))

Abstract

Nowadays, the definition “cancer stem cells” (CSCs) is widely accepted in the science community. Although, some authors think that this is a new definition in biology, the idea of CSCs has existed for more than 50 years. In recent years, the relations between “stem cells” and “cancer stem cells” gradually explored. Almost studies showed that cancer stem cells could be produced from stem cells with some specific mutations in the genome. However, CSCs also were produced by some other ways that did not directly related to stem cells. This chapter summarized characteristics of CSCs as well as their origins. The relationship between stem cells and CSCs was identified gradually. CSCs can be derived from both stem cells and non-stem cells. Therefore, it is essential to understand CSCs as cell population exhibiting stemness and high tumorigenesis. CSCs are present in almost all cancer cell lines, including breast cancer cell lines. These cells are formed directly from mutated stem cells or indirectly from cancer cells. Dysregulation of the self-renewal mechanism of stem cells can result in the formation of CSCs having a high tumorigenic capacity. Cancer cells that change gene expression by their self-renewal can also acquire stemness.

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References

  • Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J., & Clarke, M. F. (2003). Prospective identification of tumorigenic breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 100(7), 3983–3988. doi:10.1073/pnas.0530291100.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Aractingi, S., Kanitakis, J., Euvrard, S., Le Danff, C., Peguillet, I., Khosrotehrani, K., … Carosella, E. D. (2005). Skin carcinoma arising from donor cells in a kidney transplant recipient. Cancer Research, 65(5), 1755–1760. doi:10.1158/0008-5472.can-04-2783.

  • Atkinson, R. L., Yang, W. T., Rosen, D. G., Landis, M. D., Wong, H., Lewis, M. T., … Chang, J. C. (2013). Cancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficiency. Breast Cancer Research, 15(5), R77. doi:10.1186/bcr3471.

  • Bachoo, R. M., Maher, E. A., Ligon, K. L., Sharpless, N. E., Chan, S. S., You, M. J., … DePinho, R. A. (2002). Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell, 1(3), 269–277.

    Google Scholar 

  • Bane, A., Viloria-Petit, A., Pinnaduwage, D., Mulligan, A. M., O'Malley, F. P., & Andrulis, I. L. (2013). Clinical-pathologic significance of cancer stem cell marker expression in familial breast cancers. Breast Cancer Research and Treatment, 140(1), 195–205. doi:10.1007/s10549-013-2591-1.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Bartkova, J., Horejsi, Z., Koed, K., Kramer, A., Tort, F., Zieger, K., … Bartek, J. (2005). DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature, 434(7035), 864–870. doi:10.1038/nature03482.

  • Becker, A. J., Mc, C. E., & Till, J. E. (1963). Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature, 197, 452–454.

    Article  CAS  PubMed  Google Scholar 

  • Bergsmedh, A., Szeles, A., Henriksson, M., Bratt, A., Folkman, M. J., Spetz, A. L., & Holmgren, L. (2001). Horizontal transfer of oncogenes by uptake of apoptotic bodies. Proceedings of the National Academy of Sciences of the United States of America, 98(11), 6407–6411. doi:10.1073/pnas.101129998.

  • Bergsmedh, A., Szeles, A., Spetz, A. L., & Holmgren, L. (2002). Loss of the p21(Cip1/Waf1) cyclin kinase inhibitor results in propagation of horizontally transferred DNA. Cancer Research, 62(2), 575–579.

    CAS  PubMed  Google Scholar 

  • Bjerkvig, R., Tysnes, B. B., Aboody, K. S., Najbauer, J., & Terzis, A. J. (2005). Opinion: The origin of the cancer stem cell: Current controversies and new insights. Nature Reviews Cancer, 5(11), 899–904. doi:10.1038/nrc1740.

    Article  CAS  PubMed  Google Scholar 

  • Bonnet, D., & Dick, J. E. (1997). Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Medicine, 3(7), 730–737.

    Article  CAS  PubMed  Google Scholar 

  • Brunschwig, A., Southam, C. M., & Levin, A. G. (1965). Host resistance to cancer. Clinical experiments by homotransplants, autotransplants and admixture of autologous leucocytes. Annals of Surgery, 162(3), 416–425.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Cai, C., & Zhu, X. (2012). The Wnt/beta-catenin pathway regulates self-renewal of cancer stem-like cells in human gastric cancer. Molecular Medicine Reports, 5(5), 1191–1196. doi:10.3892/mmr.2012.802.

    CAS  PubMed  Google Scholar 

  • Chaffer, C. L., Brueckmann, I., Scheel, C., Kaestli, A. J., Wiggins, P. A., Rodrigues, L. O., … Weinberg, R. A. (2011). Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proceedings of the National Academy of Sciences of the United States of America, 108(19), 7950–7955. doi:10.1073/pnas.1102454108.

  • Chang, B., Liu, G., Xue, F., Rosen, D. G., Xiao, L., Wang, X., & Liu, J. (2009). ALDH1 expression correlates with favorable prognosis in ovarian cancers. Modern Pathology, 22(6), 817–823. doi:10.1038/modpathol.2009.35.

  • Chao, M. P., Weissman, I. L., & Majeti, R. (2012). The CD47-SIRPalpha pathway in cancer immune evasion and potential therapeutic implications. Current Opinion in Immunology, 24(2), 225–232. doi:10.1016/j.coi.2012.01.010.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Chen, C., Wei, Y., Hummel, M., Hoffmann, T. K., Gross, M., Kaufmann, A. M., & Albers, A. E. (2011). Evidence for epithelial-mesenchymal transition in cancer stem cells of head and neck squamous cell carcinoma. PLoS One, 6(1), e16466. doi:10.1371/journal.pone.0016466.

  • Cho, R. W., Wang, X., Diehn, M., Shedden, K., Chen, G. Y., Sherlock, G., … Clarke, M. F. (2008). Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells, 26(2), 364–371. doi:10.1634/stemcells.2007-0440.

  • Collins, A. T., Berry, P. A., Hyde, C., Stower, M. J., & Maitland, N. J. (2005). Prospective identification of tumorigenic prostate cancer stem cells. Cancer Research, 65(23), 10946–10951. doi:10.1158/0008-5472.can-05-2018.

    Article  CAS  PubMed  Google Scholar 

  • Dalerba, P., Dylla, S. J., Park, I. K., Liu, R., Wang, X., Cho, R. W., … Clarke, M. F. (2007). Phenotypic characterization of human colorectal cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America, 104(24), 10158–10163. doi:10.1073/pnas.0703478104.

  • Daniele, S., Costa, B., Zappelli, E., Da Pozzo, E., Sestito, S., Nesi, G., … Martini, C. (2015). Combined inhibition of AKT/mTOR and MDM2 enhances glioblastoma multiforme cell apoptosis and differentiation of cancer stem cells. Scientific Reports, 5, 9956. doi:10.1038/srep09956.

  • Di Pompo, G., Salerno, M., Rotili, D., Valente, S., Zwergel, C., Avnet, S., … Mai, A. (2015). Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5b00126.

  • Ding, J., Jin, W., Chen, C., Shao, Z., & Wu, J. (2012). Tumor associated macrophage × cancer cell hybrids may acquire cancer stem cell properties in breast cancer. PLoS One, 7(7), e41942. doi:10.1371/journal.pone.0041942.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Dong, H. H., Xiang, S., Liang, H. F., Li, C. H., Zhang, Z. W., & Chen, X. P. (2013). The niche of hepatic cancer stem cell and cancer recurrence. Medical Hypotheses, 80(5), 666–668. doi:10.1016/j.mehy.2013.01.021.

    Article  CAS  PubMed  Google Scholar 

  • Duelli, D., & Lazebnik, Y. (2003). Cell fusion: A hidden enemy? Cancer Cell, 3(5), 445–448.

    Article  CAS  PubMed  Google Scholar 

  • Eramo, A., Lotti, F., Sette, G., Pilozzi, E., Biffoni, M., Di Virgilio, A., … De Maria, R. (2008). Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death and Differentiation, 15(3), 504–514. doi:10.1038/sj.cdd.4402283.

  • Fan, H., & Lu, S. (2014) Fusion of human bone hemopoietic stem cell with esophageal carcinoma cells didn’t generate esophageal cancer stem cell. Neoplasma, 61(5), 540–545.

    Google Scholar 

  • Fang, D., Nguyen, T. K., Leishear, K., Finko, R., Kulp, A. N., Hotz, S., … Herlyn, M. (2005). A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Research, 65(20), 9328–9337. doi:10.1158/0008-5472.can-05-1343.

  • Farnie, G., & Clarke, R. B. (2007). Mammary stem cells and breast cancer—role of Notch signalling. Stem Cell Reviews, 3(2), 169–175.

    Article  CAS  PubMed  Google Scholar 

  • Fukusumi, T., Ishii, H., Konno, M., Yasui, T., Nakahara, S., Takenaka, Y., … Inohara, H. (2014). CD10 as a novel marker of therapeutic resistance and cancer stem cells in head and neck squamous cell carcinoma. British Journal of Cancer, 111(3), 506–514. doi:10.1038/bjc.2014.289.

  • Gilbert, C. A., & Ross, A. H. (2009). Cancer stem cells: Cell culture, markers, and targets for new therapies. Journal of Cellular Biochemistry, 108(5), 1031–1038. doi:10.1002/jcb.22350.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Ginestier, C., Hur, M. H., Charafe-Jauffret, E., Monville, F., Dutcher, J., Brown, M., … Dontu, G. (2007). ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell, 1(5), 555–567. doi:10.1016/j.stem.2007.08.014.

  • Gong, A., & Huang, S. (2012). FoxM1 and Wnt/beta-catenin signaling in glioma stem cells. Cancer Research, 72(22), 5658–5662. doi:10.1158/0008-5472.can-12-0953.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Gorgoulis, V. G., Vassiliou, L. V., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., … Halazonetis, T. D. (2005). Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature, 434(7035), 907–913. doi:10.1038/nature03485.

  • Gu, G., Yuan, J., Wills, M., & Kasper, S. (2007). Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo. Cancer Research, 67(10), 4807–4815. doi:10.1158/0008-5472.can-06-4608.

    Article  CAS  PubMed  Google Scholar 

  • Gupta, P. B., Fillmore, C. M., Jiang, G., Shapira, S. D., Tao, K., Kuperwasser, C., & Lander, E. S. (2011). Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell, 146(4), 633–644. doi:10.1016/j.cell.2011.07.026.

  • Guzman, M. L., & Jordan, C. T. (2004). Considerations for targeting malignant stem cells in leukemia. Cancer Control, 11(2), 97–104.

    PubMed  Google Scholar 

  • Hamburger, A. W., & Salmon, S. E. (1977). Primary bioassay of human tumor stem cells. Science, 197(4302), 461–463.

    Article  CAS  PubMed  Google Scholar 

  • Harris, H., & Watkins, J. F. (1965). Hybrid cells derived from mouse and man: Artificial heterokaryons of mammalian cells from different species. Nature, 205, 640–646.

    Article  CAS  PubMed  Google Scholar 

  • Hashimoto, N., Tsunedomi, R., Yoshimura, K., Watanabe, Y., Hazama, S., & Oka, M. (2014). Cancer stem-like sphere cells induced from de-differentiated hepatocellular carcinoma-derived cell lines possess the resistance to anti-cancer drugs. BMC Cancer, 14, 722. doi:10.1186/1471-2407-14-722.

    Article  PubMed Central  PubMed  Google Scholar 

  • He, Q. Z., Luo, X. Z., Wang, K., Zhou, Q., Ao, H., Yang, Y., … Duan, T. (2014). Isolation and characterization of cancer stem cells from high-grade serous ovarian carcinomas. Cellular Physiology and Biochemistry, 33(1), 173–184. doi:10.1159/000356660.

  • He, S., Nakada, D., & Morrison, S. J. (2009). Mechanisms of stem cell self-renewal. Annual Review of Cell and Developmental Biology, 25, 377–406. doi:10.1146/annurev.cellbio.042308.113248.

    Article  CAS  PubMed  Google Scholar 

  • Ho, M. M., Ng, A. V., Lam, S., & Hung, J. Y. (2007). Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Research, 67(10), 4827–4833. doi:10.1158/0008-5472.can-06-3557.

    Article  CAS  PubMed  Google Scholar 

  • Holmgren, L., Szeles, A., Rajnavolgyi, E., Folkman, J., Klein, G., Ernberg, I., & Falk, K. I. (1999). Horizontal transfer of DNA by the uptake of apoptotic bodies. Blood, 93(11), 3956–3963.

    Google Scholar 

  • Horsley, V., Jansen, K. M., Mills, S. T., & Pavlath, G. K. (2003). IL-4 acts as a myoblast recruitment factor during mammalian muscle growth. Cell, 113(4), 483–494.

    Article  CAS  PubMed  Google Scholar 

  • Horsley, V., & Pavlath, G. K. (2004). Forming a multinucleated cell: Molecules that regulate myoblast fusion. Cells, Tissues, Organs, 176(1–3), 67–78. doi:10.1159/000075028.

    Article  PubMed  Google Scholar 

  • Iacopino, F., Angelucci, C., Piacentini, R., Biamonte, F., Mangiola, A., Maira, G., … Sica, G. (2014). Isolation of cancer stem cells from three human glioblastoma cell lines: Characterization of two selected clones. PLoS One, 9(8), e105166. doi:10.1371/journal.pone.0105166.

  • Iliopoulos, D., Hirsch, H. A., & Struhl, K. (2009). An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell, 139(4), 693–706. doi:10.1016/j.cell.2009.10.014.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Iliopoulos, D., Hirsch, H. A., Wang, G., & Struhl, K. (2011). Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proceedings of the National Academy of Sciences of the United States of America, 108(4), 1397–1402. doi:10.1073/pnas.1018898108.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Ilyas, M., Straub, J., Tomlinson, I. P., & Bodmer, W. F. (1999). Genetic pathways in colorectal and other cancers. European Journal of Cancer, 35(3), 335–351.

    Article  CAS  PubMed  Google Scholar 

  • Jiang, F., Qiu, Q., Khanna, A., Todd, N. W., Deepak, J., Xing, L., … Katz, R. L. (2009). Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer. Molecular Cancer Research, 7(3), 330–338. doi:10.1158/1541-7786.mcr-08-0393.

  • Kang, E. J., Jung, H., Woo, O. H., Park, K. H., Woo, S. U., Yang, D. S., … Seo, J. H. (2014). Association of aldehyde dehydrogenase 1 expression and biologically aggressive features in breast cancer. Neoplasma, 61(3), 352–362.

    Google Scholar 

  • Kano, Y., Ishii, H., Konno, M., Ohta, K., Nishikawa, S., Fukusumi, T., … Mori, M. (2013). Cancer stem cells depend on their own niche. Gan To Kagaku Ryoho, 40(4), 419–423.

    Google Scholar 

  • Kleinsmith, L. J., & Pierce, G. B., Jr. (1964). Multipotentiality of single embryonal carcinoma cells. Cancer Research, 24, 1544–1551.

    CAS  PubMed  Google Scholar 

  • Lapidot, T., Sirard, C., Vormoor, J., Murdoch, B., Hoang, T., Caceres-Cortes, J., … Dick, J. E. (1994). A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature, 367(6464), 645–648. doi:10.1038/367645a0

  • Lau, W. M., Teng, E., Chong, H. S., Lopez, K. A., Tay, A. Y., Salto-Tellez, M., … Chan, S. L. (2014). CD44v8-10 is a cancer-specific marker for gastric cancer stem cells. Cancer Research, 74(9), 2630–2641. doi:10.1158/0008-5472.can-13-2309.

  • Lenkiewicz, M., Li, N., & Singh, S. K. (2009). Culture and isolation of brain tumor initiating cells. Current Protocols in Stem Cell Biology [Chap. 3, Unit 3.3]. doi:10.1002/9780470151808.sc0303s11.

  • Li, C., Heidt, D. G., Dalerba, P., Burant, C. F., Zhang, L., Adsay, V., … Simeone, D. M. (2007). Identification of pancreatic cancer stem cells. Cancer Research, 67(3), 1030–1037. doi:10.1158/0008-5472.can-06-2030.

  • Li, H., Feng, Z., Tsang, T. C., Tang, T., Jia, X., He, X., … Meade-Tollin, L. C. (2014). Fusion of HepG2 cells with mesenchymal stem cells increases cancer associated and malignant properties: An in vivo metastasis model. Oncol Rep, 32(2), 539–547. doi:10.3892/or.2014.3264.

  • Li, T., Su, Y., Mei, Y., Leng, Q., Leng, B., Liu, Z., … Jiang, F. (2010). ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients’ outcome. Laboratory Investigation, 90(2), 234–244. doi:10.1038/labinvest.2009.127.

  • Liang, S., Furuhashi, M., Nakane, R., Nakazawa, S., Goudarzi, H., Hamada, J., & Iizasa, H. (2013). Isolation and characterization of human breast cancer cells with SOX2 promoter activity. Biochemical and Biophysical Research Communications, 437(2), 205–211. doi:10.1016/j.bbrc.2013.06.038.

  • Lim, E., Vaillant, F., Wu, D., Forrest, N. C., Pal, B., Hart, A. H., … Lindeman, G. J. (2009). Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nature Medicine, 15(8), 907–913. doi:10.1038/nm.2000.

  • Liu, H., Zhang, W., Jia, Y., Yu, Q., Grau, G. E., Peng, L., … Lou, J. (2013). Single-cell clones of liver cancer stem cells have the potential of differentiating into different types of tumor cells. Cell Death and Disease, 4, e857. doi:10.1038/cddis.2013.340.

  • Luo, Y., Nguyen, N., & Fujita, M. (2013). Isolation of human melanoma stem cells using ALDH as a marker. Current Protocols in Stem Cell Biology, 26 [Unit 3.8]. doi:10.1002/9780470151808.sc0308s26.

  • Ma, S., Chan, K. W., Lee, T. K., Tang, K. H., Wo, J. Y., Zheng, B. J., & Guan, X. Y. (2008). Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations. Molecular Cancer Research, 6(7), 1146–1153. doi:10.1158/1541-7786.mcr-08-0035.

  • Ma, N., Thanan, R., Kobayashi, H., Hammam, O., Wishahi, M., El Leithy, T., … Kawanishi, S. (2011). Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosoma haematobium infection. Biochemical and Biophysical Research Communications, 414(2), 344–349. doi:10.1016/j.bbrc.2011.09.073.

  • Malhotra, G. K., Zhao, X., Band, H., & Band, V. (2011). Shared signaling pathways in normal and breast cancer stem cells. Journal of Carcinogenesis, 10, 38. doi:10.4103/1477-3163.91413.

    Article  PubMed Central  PubMed  Google Scholar 

  • Mather, J. P., Roberts, P. E., Pan, Z., Chen, F., Hooley, J., Young, P., … Moore, P. A. (2013). Isolation of cancer stem like cells from human adenosquamous carcinoma of the lung supports a monoclonal origin from a multipotential tissue stem cell. PLoS One, 8(12), e79456. doi:10.1371/journal.pone.0079456.

  • Matsuda, S., Yan, T., Mizutani, A., Sota, T., Hiramoto, Y., Prieto-Vila, M., … Seno, M. (2014). Cancer stem cells maintain a hierarchy of differentiation by creating their niche. International Journal of Cancer, 135(1), 27–36. doi:10.1002/ijc.28648.

  • Matsui, W., Huff, C. A., Wang, Q., Malehorn, M. T., Barber, J., Tanhehco, Y., … Jones, R. J. (2004). Characterization of clonogenic multiple myeloma cells. Blood, 103(6), 2332–2336. doi:10.1182/blood-2003-09-3064.

  • Mekler, L. B. (1971). Hybridization of transformed cells with lymphocytes as 1 of the probable causes of the progression leading to the development of metastatic malignant cells. Vestnik Akademii Meditsinskikh Nauk SSSR, 26(8), 80–89.

    CAS  PubMed  Google Scholar 

  • Meyer, M. J., Fleming, J. M., Ali, M. A., Pesesky, M. W., Ginsburg, E., & Vonderhaar, B. K. (2009). Dynamic regulation of CD24 and the invasive, CD44posCD24neg phenotype in breast cancer cell lines. Breast Cancer Research, 11(6), R82. doi:10.1186/bcr2449.

    Article  PubMed Central  PubMed  Google Scholar 

  • Miller, A. B., Howe, G. R., Sherman, G. J., Lindsay, J. P., Yaffe, M. J., Dinner, P. J., … Preston, D. L. (1989). Mortality from breast cancer after irradiation during fluoroscopic examinations in patients being treated for tuberculosis. The New England Journal of Medicine, 321(19), 1285–1289. doi:10.1056/nejm198911093211902.

  • Modan, B., Chetrit, A., Alfandary, E., & Katz, L. (1989). Increased risk of breast cancer after low-dose irradiation. Lancet, 1(8639), 629–631.

    Article  CAS  PubMed  Google Scholar 

  • Molyneux, G., Geyer, F. C., Magnay, F. A., McCarthy, A., Kendrick, H., Natrajan, R., … Smalley, M. J. (2010). BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell, 7(3), 403–417. doi:10.1016/j.stem.2010.07.010.

  • Monteiro, J., Gaspar, C., Richer, W., Franken, P. F., Sacchetti, A., Joosten, R., … Fodde, R. (2014). Cancer stemness in Wnt-driven mammary tumorigenesis. Carcinogenesis, 35(1), 2–13. doi:10.1093/carcin/bgt279.

  • O’Brien, C. A., Pollett, A., Gallinger, S., & Dick, J. E. (2007). A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature, 445(7123), 106–110. doi:10.1038/nature05372.

    Article  PubMed  Google Scholar 

  • Ong, B. A., Vega, K. J., & Houchen, C. W. (2014). Intestinal stem cells and the colorectal cancer microenvironment. World Journal of Gastroenterology, 20(8), 1898–1909. doi:10.3748/wjg.v20.i8.1898.

    Article  PubMed Central  PubMed  Google Scholar 

  • Pawelek, J. M. (2000). Tumour cell hybridization and metastasis revisited. Melanoma Research, 10(6), 507–514.

    Article  CAS  PubMed  Google Scholar 

  • Pawelek, J. M. (2014). Fusion of bone marrow-derived cells with cancer cells: Metastasis as a secondary disease in cancer. Chinese Journal of Cancer, 33(3), 133–139. doi:10.5732/cjc.013.10243.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Pearce, D. J., Taussig, D., Simpson, C., Allen, K., Rohatiner, A. Z., Lister, T. A., & Bonnet, D. (2005). Characterization of cells with a high aldehyde dehydrogenase activity from cord blood and acute myeloid leukemia samples. Stem Cells, 23(6), 752–760. doi:10.1634/stemcells.2004-0292.

  • Pece, S., Tosoni, D., Confalonieri, S., Mazzarol, G., Vecchi, M., Ronzoni, S., … Di Fiore, P. P. (2010). Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell, 140(1), 62–73. doi:10.1016/j.cell.2009.12.007.

  • Pham, P. V., Phan, N. L., Nguyen, N. T., Truong, N. H., Duong, T. T., Le, D. V., … Phan, N. K. (2011). Differentiation of breast cancer stem cells by knockdown of CD44: Promising differentiation therapy. Journal of Translational Medicine, 9, 209. doi:10.1186/1479-5876-9-209.

  • Piggott, L., Omidvar, N., Marti Perez, S., Eberl, M., & Clarkson, R. W. (2011). Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research, 13(5), R88. doi:10.1186/bcr2945.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Pomerantz, J., & Blau, H. M. (2004). Nuclear reprogramming: A key to stem cell function in regenerative medicine. Nature Cell Biology, 6(9), 810–816. doi:10.1038/ncb0904-810.

    Article  CAS  PubMed  Google Scholar 

  • Ponti, D., Costa, A., Zaffaroni, N., Pratesi, G., Petrangolini, G., Coradini, D., … Daidone, M. G. (2005). Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Research, 65(13), 5506–5511. doi:10.1158/0008-5472.can-05-0626.

  • Prasetyanti, P. R., Zimberlin, C., De Sousa, E. M. F., & Medema, J. P. (2013). Isolation and propagation of colon cancer stem cells. Methods in Molecular Biology, 1035, 247–259. doi:10.1007/978-1-62703-508-8_21.

    Article  CAS  PubMed  Google Scholar 

  • Prince, M. E., Sivanandan, R., Kaczorowski, A., Wolf, G. T., Kaplan, M. J., Dalerba, P., … Ailles, L. E. (2007). Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proceedings of the National Academy of Sciences of the United States of America, 104(3), 973–978. doi:10.1073/pnas.0610117104.

  • Proia, T. A., Keller, P. J., Gupta, P. B., Klebba, I., Jones, A. D., Sedic, M., … Kuperwasser, C. (2011). Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell, 8(2), 149–163. doi:10.1016/j.stem.2010.12.007.

  • Rachkovsky, M., Sodi, S., Chakraborty, A., Avissar, Y., Bolognia, J., McNiff, J. M., … Pawelek, J. (1998). Melanoma x macrophage hybrids with enhanced metastatic potential. Clinical and Experimental Metastasis, 16(4), 299–312.

    Google Scholar 

  • Rappa, G., Mercapide, J., & Lorico, A. (2012). Spontaneous formation of tumorigenic hybrids between breast cancer and multipotent stromal cells is a source of tumor heterogeneity. American Journal of Pathology, 180(6), 2504–2515. doi:10.1016/j.ajpath.2012.02.020.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001). Stem cells, cancer, and cancer stem cells. Nature, 414(6859), 105–111. doi:10.1038/35102167.

    Article  CAS  PubMed  Google Scholar 

  • Ricci-Vitiani, L., Lombardi, D. G., Pilozzi, E., Biffoni, M., Todaro, M., Peschle, C., & De Maria, R. (2007). Identification and expansion of human colon-cancer-initiating cells. Nature, 445(7123), 111–115. doi:10.1038/nature05384.

  • Rountree, C. B., Senadheera, S., Mato, J. M., Crooks, G. M., & Lu, S. C. (2008). Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. Hepatology, 47(4), 1288–1297. doi:10.1002/hep.22141.

    Article  CAS  PubMed  Google Scholar 

  • Saadin, K., & White, I. M. (2013). Breast cancer stem cell enrichment and isolation by mammosphere culture and its potential diagnostic applications. Expert Review of Molecular Diagnostics, 13(1), 49–60. doi:10.1586/erm.12.117.

    Article  CAS  PubMed  Google Scholar 

  • Sabet, M. N., Rakhshan, A., Erfani, E., & Madjd, Z. (2014). Co-expression of putative cancer stem cell markers, CD133 and Nestin, in skin tumors. Asian Pacific Journal of Cancer Prevention, 15(19), 8161–8169.

    Article  PubMed  Google Scholar 

  • Sarfati, M., Fortin, G., Raymond, M., & Susin, S. (2008). CD47 in the immune response: Role of thrombospondin and SIRP-alpha reverse signaling. Current Drug Targets, 9(10), 842–850.

    Article  CAS  PubMed  Google Scholar 

  • Simeone, D. M. (2008). Pancreatic cancer stem cells: Implications for the treatment of pancreatic cancer. Clinical Cancer Research, 14(18), 5646–5648. doi:10.1158/1078-0432.ccr-08-0584.

    Article  CAS  PubMed  Google Scholar 

  • Singh, S. K., Hawkins, C., Clarke, I. D., Squire, J. A., Bayani, J., Hide, T., … Dirks, P. B. (2004). Identification of human brain tumour initiating cells. Nature, 432(7015), 396–401. doi:10.1038/nature03128.

  • Song, Z., Yue, W., Wei, B., Wang, N., Li, T., Guan, L., … Chen, L. (2011). Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer. PLoS One, 6(3), e17687. doi:10.1371/journal.pone.0017687.

  • Stevens, L. C. (1964). Experimental production of testicular teratomas in mice. Proceedings of the National Academy of Sciences of the United States of America, 52, 654–661.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Takakura, N. (2012). Formation and regulation of the cancer stem cell niche. Cancer Science, 103(7), 1177–1181. doi:10.1111/j.1349-7006.2012.02270.x.

    Article  CAS  PubMed  Google Scholar 

  • Tomasetti, C., & Vogelstein, B. (2015). Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science, 347(6217), 78–81. doi:10.1126/science.1260825.

    Article  CAS  PubMed  Google Scholar 

  • Tomuleasa, C., Soritau, O., Rus-Ciuca, D., Pop, T., Todea, D., Mosteanu, O., … Irimie, A. (2010). Isolation and characterization of hepatic cancer cells with stem-like properties from hepatocellular carcinoma. Journal of Gastrointestinal and Liver Diseases, 19(1), 61–67.

    Google Scholar 

  • Varnat, F., Duquet, A., Malerba, M., Zbinden, M., Mas, C., Gervaz, P., & Ruiz i Altaba, A. (2009). Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. EMBO Molecular Medicine, 1(6–7), 338–351. doi:10.1002/emmm.200900039.

  • Vassilopoulos, A., Wang, R. H., Petrovas, C., Ambrozak, D., Koup, R., & Deng, C. X. (2008). Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells. International Journal of Biological Sciences, 4(3), 133–142.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Vidal, S. J., Quinn, S. A., de la Iglesia-Vicente, J., Bonal, D. M., Rodriguez-Bravo, V., Firpo-Betancourt, A., … Domingo-Domenech, J. (2014). Isolation of cancer stem cells from human prostate cancer samples. Journal of Visualized Experiments (85). doi:10.3791/51332.

  • Vignery, A. (2000). Osteoclasts and giant cells: Macrophage-macrophage fusion mechanism. International Journal of Experimental Pathology, 81(5), 291–304.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Vu, N. B., Nguyen, T. T., Tran, L. C., Do, C. D., Nguyen, B. H., Phan, N. K., & Pham, P. V. (2013). Doxorubicin and 5-fluorouracil resistant hepatic cancer cells demonstrate stem-like properties. Cytotechnology, 65(4), 491–503. doi:10.1007/s10616-012-9511-9.

  • Walia, V., & Elble, R. C. (2010). Enrichment for breast cancer cells with stem/progenitor properties by differential adhesion. Stem Cells and Development, 19(8), 1175–1182. doi:10.1089/scd.2009.0430.

    Article  CAS  PubMed  Google Scholar 

  • Wang, P., Branch, D. R., Bali, M., Schultz, G. A., Goss, P. E., & Jin, T. (2003). The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells. Biochemistry Journal, 375(Pt 1), 199–205. doi:10.1042/bj20030579.

    Article  CAS  Google Scholar 

  • Wang, Y., Fan, H., Zhou, B., Ju, Z., Yu, L., Guo, L., … Lu, S. (2012). Fusion of human umbilical cord mesenchymal stem cells with esophageal carcinoma cells inhibits the tumorigenicity of esophageal carcinoma cells. International Journal of Oncology, 40(2), 370–377. doi:10.3892/ijo.2011.1232.

  • Wang, L., Guo, H., Lin, C., Yang, L., & Wang, X. (2014). Enrichment and characterization of cancer stemlike cells from a cervical cancer cell line. Molecular Medicine Reports, 9(6), 2117–2123. doi:10.3892/mmr.2014.2063.

    PubMed Central  CAS  PubMed  Google Scholar 

  • Warner, T. F. (1975). Cell hybridizaiton: An explanation for the phenotypic diversity of certain tumours. Medical Hypotheses, 1(1), 51–57.

    Article  CAS  PubMed  Google Scholar 

  • Wei, P., Niu, M., Pan, S., Zhou, Y., Shuai, C., Wang, J., … Li, G. (2014). Cancer stem-like cell: A novel target for nasopharyngeal carcinoma therapy. Current Stem Cell Research & Therapy, 5(2), 44. doi:10.1186/scrt433.

  • White, A. C., & Lowry, W. E. (2015). Refining the role for adult stem cells as cancer cells of origin. Trends in Cell Biology, 25(1), 11–20. doi:10.1016/j.tcb.2014.08.008.

    Article  CAS  PubMed  Google Scholar 

  • Xu, M. H., Gao, X., Luo, D., Zhou, X. D., Xiong, W., & Liu, G. X. (2014). EMT and acquisition of stem cell-like properties are involved in spontaneous formation of tumorigenic hybrids between lung cancer and bone marrow-derived mesenchymal stem cells. PLoS One, 9(2), e87893. doi:10.1371/journal.pone.0087893.

    Article  PubMed Central  PubMed  Google Scholar 

  • Yang, Z. F., Ho, D. W., Ng, M. N., Lau, C. K., Yu, W. C., Ngai, P., … Fan, S. T. (2008). Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell, 13(2), 153–166. doi:10.1016/j.ccr.2008.01.013.

  • Yeung, T. M., Gandhi, S. C., Wilding, J. L., Muschel, R., & Bodmer, W. F. (2010). Cancer stem cells from colorectal cancer-derived cell lines. Proceedings of the National Academy of Sciences of the United States of America, 107(8), 3722–3727. doi:10.1073/pnas.0915135107.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Zardawi, S. J., O’Toole, S. A., Sutherland, R. L., & Musgrove, E. A. (2009). Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer. Histology and Histopathology, 24(3), 385–398.

    CAS  PubMed  Google Scholar 

  • Zhao, Q. W., Zhou, Y. W., Li, W. X., Kang, B., Zhang, X. Q., Yang, Y., … Wang, Y. J. (2015). Akt mediated phosphorylation of Oct4 is associated with the proliferation of stemlike cancer cells. Oncology Reports, 33(4), 1621–1629. doi:10.3892/or.2015.3752.

  • Zhou, F., Mu, Y. D., Liang, J., Liu, Z. X., Chen, H. S., & Zhang, J. F. (2014). Expression and prognostic value of tumor stem cell markers ALDH1 and CD133 in colorectal carcinoma. Oncology Letters, 7(2), 507–512. doi:10.3892/ol.2013.1723.

    PubMed Central  PubMed  Google Scholar 

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  1. Animal Physiology and Biotechnology, Vietnam National University of Science, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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Van Pham, P. (2015). Stem Cells and Cancer Stem Cells. In: Breast Cancer Stem Cells & Therapy Resistance. SpringerBriefs in Stem Cells. Springer, Cham. https://doi.org/10.1007/978-3-319-22020-8_2

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