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Autophagy and Antigen Presentation

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Autophagy Networks in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Macroautophagy (hereafter referred to as autophagy) is a eukaryotic catabolic pathway that eliminates intracellular contents and thereby provides cells with a source of nutrients. This fundamental pathway of cellular degradation also participates in immunity and inflammation. The capacity of autophagy to traffic, and to degrade, cytosolic protein is exploited by immune cells as a means to elicit antigen presentation. Here, we will summarize the current knowledge about the intersection of both classical and non-canonical autophagy with pathways of antigen presentation. While the role of autophagy in major histocompatibility complex class II (MHC II) presentation is well documented, autophagy is also implicated in endogenous MHC I presentation and MHC I cross-presentation. Thus, autophagy is a major effector of antigen presentation and has the capacity to impact host immunity and tolerance.

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Abbreviations

3-MA:

3-methyladenine

Ag85B:

Antigen 85B

AMPKα1:

Adenosine monophosphate activating kinase-α1

APC:

Antigen presenting cell

Atg:

Autophagy-related gene

BMDC:

Bone marrow-derived dendritic cell

BMDM:

Bone marrow-derived macrophage

CLIP:

Class-II-associated li peptide

CMA:

Chaperone-mediated autophagy

CRP:

C-reactive protein

DALIS:

Dendritic cell aggresome-like induce structure

DC:

Dendritic cell

DRibbles:

Defective ribosomal products-containing blebs

EBNA1:

Epstein-Barr virus nuclear antigen 1

EBV:

Epstein-Barr virus

ENMA:

Endosome-mediated autophagy

ER:

Endoplasmic reticulum

gB:

Glycoprotein B

GCN2:

General control nonderepressible 2

GFP:

Green fluorescent protein

HEL:

Hen egg lysozyme

HIV:

Human immunodeficiency virus

Hsc70:

Heat shock cognate protein of 70 kDa

HSV:

Herpes simplex virus

li:

Invariant chain

Lamp-2a:

Lysosomal-associated membrane protein 2a

LAP:

LC3-associated phagocytosis

LC3:

Microtubule-associated protein 1 light chain 3

MEF:

Mouse embryonic fibroblasts

MHC:

Major histocompatibility complex

MIIC:

Major histocompatibility complex class II compartment

moDC:

Monocyte-derived dendritic cell

MP1:

Matrix protein 1

OVA:

Ovalbumin

TAP:

Transporter-associated with antigen processing

TCR:

T cell receptor

TEC:

Thymic epithelial cell

TIM-4:

T cell immunoglobulin and mucin domain-containing molecule 4

TLR:

Toll-like receptor

αAl2O3-OVA:

Ovalbumin-conjugated αAl2O3

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Acknowledgments

C. M. is supported by La Fondation pour la Recherche Médicale.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, 30 Flemington Rd, Parkville, VIC, 3010, Australia

    Christophe Macri & Justine D. Mintern

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  1. Christophe Macri
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  2. Justine D. Mintern
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Correspondence to Justine D. Mintern .

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Editors and Affiliations

  1. Centre de Recherche des Cordeliers, UMRS 1138 – Team 11,, Paris, France

    Maria Chiara Maiuri

  2. Multi Medica Fondazione Onlus, Milan, Italy

    Daniela De Stefano

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Macri, C., Mintern, J.D. (2016). Autophagy and Antigen Presentation. In: Maiuri, M., De Stefano, D. (eds) Autophagy Networks in Inflammation. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-30079-5_8

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  • DOI: https://doi.org/10.1007/978-3-319-30079-5_8

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