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Pathophysiology of Subclinical Brain Damage in Hypertension: Large Artery Disease

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Hypertension and Brain Damage

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

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Abstract

Hypertension induces subclinical damage in the large elastic arteries and in the small brain arteries. Better understanding of the haemodynamic consequences of hypertension on brain damage is necessary, not only to select the most appropriate therapeutic management but also to optimize prevention, which should be started early in individuals at high risk of developing brain damage. This chapter proposes an integrated pathophysiological approach in order to better understand how large artery damage influences pressure wave transmission, exaggerates subclinical brain damage and leads to cerebrovascular complications. Measurement of arterial stiffness and central blood pressure by non-invasive methods in epidemiological studies and randomized clinical trials may improve our understanding of the haemodynamic consequences of hypertension on the brain, including stroke and cognitive decline.

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Authors and Affiliations

  1. Department of Pharmacology and PARCC-INSERM U970, Hôpital Européen Georges Pompidou, Université Paris-Descartes, Assistance-Publique Hôpitaux de Paris, 56 rue Leblanc, Paris, 75015, France

    Stéphane Laurent MD, PhD & Pierre Boutouyrie MD, PhD

  2. Department of Neurology of Adults, Medical University of Gdańsk, Gdansk, Poland

    Dariusz Gasecki MD, PhD

  3. Poland Hypertension Unit, Department of Hypertension and Diabetology, Medical University of Gdańsk, Gdansk, Poland

    Krzysztof Narkiewicz MD, PhD

Authors
  1. Stéphane Laurent MD, PhD
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  2. Dariusz Gasecki MD, PhD
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  3. Pierre Boutouyrie MD, PhD
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  4. Krzysztof Narkiewicz MD, PhD
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Correspondence to Stéphane Laurent MD, PhD .

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  1. Hypertension & Vascular Risk Unit, Hospital Clínic, Barcelona, Spain

    Antonio Coca

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Laurent, S., Gasecki, D., Boutouyrie, P., Narkiewicz, K. (2016). Pathophysiology of Subclinical Brain Damage in Hypertension: Large Artery Disease. In: Coca, A. (eds) Hypertension and Brain Damage. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-319-32074-8_6

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