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Glycosides, Synthesis and Characterization

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Synthesis and Characterization of Glycosides

Abstract

Monosaccharides are generally defined as aldoses and ketoses connected to a polyhydroxylated skeleton [1]. In an aqueous solution, monosaccharides are subject to internal nucleophilic addition to form cyclic hemiacetal structures. When addition occurs between -OH at C(4) or -OH at C(5), and the carbonyl group, a five- or a six-member ring is formed called a furanose or a pyranose respectively. It is also known that an equilibrium exists between the open and the cyclic form, being displaced to the latter by more than 90 %. Therefore, in aqueous solution, it is more accurate to consider that most sugars are present as cyclic molecules and behave chemically as hemiacetals.

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Brito-Arias, M. (2016). Glycosides, Synthesis and Characterization. In: Synthesis and Characterization of Glycosides. Springer, Cham. https://doi.org/10.1007/978-3-319-32310-7_1

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