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Bacteriophages pp 1–13Cite as

Prophage P1: An Example of a Prophage That Is Maintained as a Plasmid

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Abstract

Integration of phage DNA with a bacterial chromosome is not the only form of lysogeny. There is a growing number of reports concerning prophages that exist in cells as plasmids. A large prophage P1 is their best known example. Its evolutionary success appears to result from efficient mechanisms that prevent its loss from a cell, a complex regulatory circuitry of its genes that allow it to quickly respond to changes in host metabolism and from benefits to cells that carry it. Additionally the wide host-range of phage and prophage P1 contributes to the spread of P1 prophage and its relatives among numerous enterobacterial genera, making them effective vectors of horizontal gene transfer that participate in the acquisition of antibiotic resistance genes by their hosts.

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Acknowledgments

This work was supported by the statutory funds for the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences.

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Authors and Affiliations

  1. Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics of the Polish Academy of Sciences, Warsaw, Poland

    Małgorzata Łobocka

  2. Autonomous Department of Microbiology, Faculty of Agriculture and Biology, Warsaw University of Life Sciences – SGGW, Warsaw, Poland

    Urszula Gągała

Authors
  1. Małgorzata Łobocka
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  2. Urszula Gągała
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Corresponding author

Correspondence to Małgorzata Łobocka .

Editor information

Editors and Affiliations

  1. Evolution Biotechnologies, Milton Keynes, UK

    David R. Harper

  2. Dept. of Microbiology, The Ohio State University Dept. of Microbiology, Mansfield, OH, USA

    Stephen T. Abedon

  3. GeneWEAVE Biosciences, Roche Molecular Systems GeneWEAVE Biosciences, Los Gatos, AR, USA

    Benjamin H. Burrowes

  4. Evolution Biotechnologies, Milton Keynes, UK

    Malcolm L. McConville

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Łobocka, M., Gągała, U. (2021). Prophage P1: An Example of a Prophage That Is Maintained as a Plasmid. In: Harper, D.R., Abedon, S.T., Burrowes, B.H., McConville, M.L. (eds) Bacteriophages. Springer, Cham. https://doi.org/10.1007/978-3-319-40598-8_54-1

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  • DOI: https://doi.org/10.1007/978-3-319-40598-8_54-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40598-8

  • Online ISBN: 978-3-319-40598-8

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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