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Genetic and Genomic Approaches to Acute Lung Injury

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Acute Lung Injury and Repair

Part of the book series: Respiratory Medicine ((RM))

Abstract

Acute lung injury (ALI) is a syndrome influenced by genetic and environmental factors, therefore, it is important to examine genetic variants, transcriptional profiles, and epigenetic marks in this disease. This chapter will focus on study design for genome-wide level analysis of genetic variants, coding and noncoding RNAs, and epigenetic marks; methods for genomic analysis and focused approaches for validation of genomic hits and independent replication; and progress that has been made to date in ALI with specific focus on human studies. At the end of the chapter, future directions and integrative analyses of these datasets, together with additional –omic data not discussed in this chapter (microbiome, metabolome, proteome) are discussed briefly.

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Authors and Affiliations

  1. Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, USA

    Ivana V. Yang

  2. Department of Epidemiology, Colorado School of Public Health, Aurora, USA

    Ivana V. Yang

  3. Center for Genes, Environment, and Health, National Jewish Health, Denver, USA

    Ivana V. Yang

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  1. Ivana V. Yang
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  1. Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina, USA

    Lynn M. Schnapp

  2. Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA

    Carol Feghali-Bostwick

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Yang, I.V. (2017). Genetic and Genomic Approaches to Acute Lung Injury. In: Schnapp, L., Feghali-Bostwick, C. (eds) Acute Lung Injury and Repair. Respiratory Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-46527-2_9

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