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Critical Foundation of the Kinetochore: The Constitutive Centromere-Associated Network (CCAN)

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Centromeres and Kinetochores

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 56))

Abstract

The kinetochore is a large protein complex, which is assembled at the centromere of a chromosome to ensure faithful chromosome segregation during M-phase. The centromere in most eukaryotes is epigenetically specified by DNA sequence-independent mechanisms. The constitutive centromere-associated network (CCAN) is a subcomplex in the kinetochore that localizes to the centromere throughout the cell cycle. The CCAN has interfaces bound to the centromeric chromatin and the spindle microtubule-binding complex; therefore, it functions as a foundation of kinetochore formation. Here, we summarize recent progress in our understanding of the structure and organization of the CCAN. We also discuss an additional role of the CCAN in the maintenance of centromere position and dynamic reorganization of the CCAN.

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Acknowledgements

The authors thank Tetsuya Hori and other members in the Fukagawa Lab for helpful discussions. This work is supported by JSPS KAKENHI Grant Numbers P25221106, JP16H06279, and JP15H05972 to TF and JP16K18491 to MH.

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  1. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, 565-0871, Japan

    Masatoshi Hara & Tatsuo Fukagawa

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  1. Masatoshi Hara
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Correspondence to Tatsuo Fukagawa .

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  1. Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Ben E. Black

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Hara, M., Fukagawa, T. (2017). Critical Foundation of the Kinetochore: The Constitutive Centromere-Associated Network (CCAN). In: Black, B. (eds) Centromeres and Kinetochores. Progress in Molecular and Subcellular Biology, vol 56. Springer, Cham. https://doi.org/10.1007/978-3-319-58592-5_2

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