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Constitutive Inference and the Problem of a Complete Variation of Factors

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Philosophy of Science

Part of the book series: European Studies in Philosophy of Science ((ESPS,volume 9))

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Abstract

This paper aims to solve a potential problem for the methodology of constitutive inference offered by Harbecke (Stud Hist Philos Sci C: Stud Hist Philos Biol Biomed Sci 54:10–19, 2015b). The methodology is ultimately based on Mill’s “method of difference”, which requires a complete variation of factors in a given frame. In constitutive contexts, such a complete variation is often impossible. The offered solution utilizes the notion of a “mechanism slice”. In a first step, an example of a currently accepted explanation in neuroscience is reconstructed, which serves as a reference point of the subsequent discussion. The regularity theory of mechanistic constitution and the corresponding methodology of constitutive inference are then introduced. Eventually, it is argued that the proposed solution accommodates well all schematic situations in which the impossibility of varying all test factors could be expected either to lead to false inferences or to preclude the establishment of correct constitutive claims.

This research has been supported by the German-Israeli Foundation for Scientific Research and Development, grant No. G-199-116.2-2013.

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Notes

  1. 1.

    I presuppose the “epistemic” rather than the “ontic” interpretation of mechanistic explanations here. According to this interpretation, mechanistic explanations are models that represent physical mechanisms in the world. This might put me in opposition to Craver’s understanding of a mechanistic explanation (cf. Craver 2007, 27).

  2. 2.

    “Composition” has been used by Machamer et al. (2000, 13), Bechtel and Abrahamsen (2005, 426), and Craver (2007, 164); “constitution” occurs in Craver (2007, 153); “constitutive relevance” is found in Craver (2007, 139). As far as I can see, the authors intend these terms widely synonymously, despite the fact that they offer different conceptual analyses for the targeted notion.

  3. 3.

    Readers already familiar with Harbecke (2010, 2013, 2014, 2015a) and Couch (2011) may want to skip Sect. 12.3 and continue with Sect. 12.4.

  4. 4.

    Compare this approach to the notion of specific types as proposed in Spohn (2006).

  5. 5.

    The mereological theory presupposed here is General Extensional Mereology (GEM) as explicated by Varzi (2009).

  6. 6.

    For an argument for this position, cf. Mellor (1977, 308–309). Note that this position differs from the position defended in Lewis (1986, 50–51), according to which only metaphysically necessary co-extensiveness ensures type identity.

  7. 7.

    Readers already familiar with Harbecke (2015b) may want to skip Sect. 12.4 and continue with Sect. 12.5.

  8. 8.

    The same-place-and-time implication follows from the definition of Constitution. See the comments on conditions (iii)(a) and (iii)(b) in Sect. 12.3.

  9. 9.

    To be precise, H O and C T have to be slightly reformulated to recognize the more complex structure of the test. For the corresponding case of causal inference, cf. Baumgartner and Graßhoff (2004, 216).

  10. 10.

    To be fair, it should be mentioned that, according to the mechanistic approach, a satisfactory description of the underlying mechanism at one level is not yet a complete explanation. To attain the latter, one would have to offer satisfactory descriptions of the mechanism at different levels (cf. Machamer et al. 2000, 13/14).

References

  • Baumgartner, M., and G. Graßhoff. 2004. Kausalität und kausales Schliessen: eine Einführung mit interaktiven Übungen. Bern: Bern Studies in the History and Philosophy of Science.

    Google Scholar 

  • Bechtel, W., and A. Abrahamsen. 2005. Explanation: A mechanist alternative. Studies in History and Philosophy of Biological and Biomedical Sciences 36(2): 421–441.

    Article  Google Scholar 

  • Bechtel, W., and R. Richardson. 1993. Discovering complexity: Decomposition and localization as scientific research strategies. New York: Princeton University Press.

    Google Scholar 

  • Bickle, J. 2003. Philosophy and neuroscience: A ruthlessly reductive account. Dordrecht: Kluwer.

    Book  Google Scholar 

  • Bliss, T., and G. Collingridge. 1993. A synaptic model of memory: Long-term potentiation in the hippocampus. Nature 361(6407): 31–39.

    Article  Google Scholar 

  • Bliss, T., and T. Lømo. 1973. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. The Journal of Physiology 232(2): 331–356.

    Article  Google Scholar 

  • Bourtchouladze, R., T. Abel, N. Berman, R. Gordon, K. Lapidus, and E.R. Kandel. 1998. Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA. Learning & Memory 5(4): 365–374.

    Google Scholar 

  • Churchland, P.S., and T.J. Sejnowski. 1992. The computational brain. Cambridge: MIT Press.

    Google Scholar 

  • Couch, M. 2011. Mechanisms and constitutive relevance. Synthese 183(3): 375–388.

    Article  Google Scholar 

  • Craver, C. 2002. Interlevel experiments and multilevel mechanisms in the neuroscience of memory. Philosophy of Science 69(3): 83–97.

    Article  Google Scholar 

  • Craver, C. 2007. Explaining the brain. New York: Oxford University Press.

    Book  Google Scholar 

  • Craver, C., and L. Darden. 2001. Discovering mechanisms in neurobiology. In Theory and method in the neurosciences, ed. P. Machamer, R. Grush, and P. McLaughlin, 112–137. Pittsburgh: University of Pittsburgh Press.

    Google Scholar 

  • Davis, S., S. Butcher, and R. Morris. 1992. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. Journal of Neuroscience 12(1): 21–34.

    Google Scholar 

  • Frey, U., S. Frey, F. Schollmeier, and M. Krug. 1996. Influence of actinomycin D, a RNA synthesis inhibitor, on long-term potentiation in rat hippocampal neurons in vivo and in vitro. The Journal of Physiology 490(Pt 3): 703.

    Article  Google Scholar 

  • Graßhoff, G., and M. May. 1995. Methodische analyse wissenschaftlichen entdeckens. Kognitionswissenschaft 5: 51–67.

    Google Scholar 

  • Grover, L., and T. Teyler. 1992. N-methyl-D-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus: Input-specific induction and preclusion in a non-tetanized pathway. Neuroscience 49(1): 7–11.

    Article  Google Scholar 

  • Harbecke, J. 2010. Mechanistic constitution in neurobiological explanations. International Studies in the Philosophy of Science 24(3): 267–285.

    Article  Google Scholar 

  • Harbecke, J. 2013. Regularity theories of mechanistic constitution in comparison. In GAP 8 Was d?rfen wir glauben? Was sollen wir tun?, ed. M. Hoeltje, T. Spitzley, and W. Spohn, 126–134. Duisburg-Essen: DuEPublico.

    Google Scholar 

  • Harbecke, J. 2014. The role of supervenience and constitution in neuroscientific research. Synthese 191(5): 725–743.

    Article  Google Scholar 

  • Harbecke, J. 2015a. Regularity constitution and the location of levels. Foundations of Science 20(3), 323–338.

    Article  Google Scholar 

  • Harbecke, J. 2015b. The regularity theory of mechanistic constitution and a methodology for constitutive inference. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 54: 10–19.

    Article  Google Scholar 

  • Harris, E., A. Ganong, and C. Cotman. 1984. Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors. Brain Research 323(1): 132–137.

    Article  Google Scholar 

  • Kimble, D. (1963). The effects of bilateral hippocampal lesions in rats. Journal of Comparative and Physiological Psychology 56(2), 273.

    Article  Google Scholar 

  • Lewis, D. 1973. Causation. The Journal of Philosophy 70(17): 556–567.

    Article  Google Scholar 

  • Lewis, D. 1986. On the plurality of worlds, vol. 322. Oxford: Basil Blackwell.

    Google Scholar 

  • Lømo, T. 2003. The discovery of long-term potentiation. Philosophical Transactions of the Royal Society. London B. Biological Science 358: 617–620.

    Article  Google Scholar 

  • Machamer, P., L. Darden, and C. Craver. 2000. Thinking about mechanisms. Philosophy of Science 67(1): 1–25.

    Article  Google Scholar 

  • Mackie, J. 1974. The cement of the Universe. Oxford: Clarendon Press.

    Google Scholar 

  • Malenka, R., J. Kauer, D. Perkel, M. Mauk, P. Kelly, R. Nicoll, and M. Waxham. 1989. An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation. Nature 340(6234): 554–557.

    Article  Google Scholar 

  • May, M. 1999. Kausales Schliessen. Eine Untersuchung ?ber kausale Erkl?rungen und Theorienbildung. Ph.D. thesis, University of Hamburg, Germany.

    Google Scholar 

  • Mellor, D.H. 1977. Natural kinds. British Journal for the Philosophy of Science 28(4): 299–312.

    Article  Google Scholar 

  • Mill, J.S. 1882/1843. A system of logic: Ratiocinative and inductive, Book III, 8th ed. London: Harper and Brothers.

    Google Scholar 

  • Morris, R. 1984. Developments of a water-maze procedure for studying spatial learning in the rat. Journal of Neuroscience Methods 11(1): 47–60.

    Article  Google Scholar 

  • Morris, R., P. Garrud, J. Rawlins, and J. O’Keefe. 1982. Place navigation impaired in rats with hippocampal lesions. Nature 297(5868): 681–683.

    Article  Google Scholar 

  • Morris, R., E. Anderson, G. Lynch, and M. Baudry. 1986. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319: 774–776.

    Article  Google Scholar 

  • Spohn, W. 2006. Causation: An alternative. The British Journal for the Philosophy of Science 57(1): 93–119.

    Article  Google Scholar 

  • Toni, N., P.-A. Buchs, I. Nikonenko, C. Bron, and D. Muller. 1999. LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite. Nature 402(6760): 421–425.

    Article  Google Scholar 

  • Varzi, A. 2009. Mereology. In Stanford Encyclopedia of Philosophy, ed. E.N. Zalta (Summer 2009 ed.). http://plato.stanford.edu/entries/mereology/.

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Harbecke, J. (2018). Constitutive Inference and the Problem of a Complete Variation of Factors. In: Christian, A., Hommen, D., Retzlaff, N., Schurz, G. (eds) Philosophy of Science. European Studies in Philosophy of Science, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-319-72577-2_12

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