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Antibody Mediated Rejection: Are We There Yet?

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Essentials in Lung Transplantation

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Abstract

The diagnosis, management and treatment of antibody-mediated rejection (AMR) following lung transplantation remains challenging, but is associated with both acute and chronic lung allograft dysfunction (CLAD). Confidence for the diagnosis of AMR increases according to how many of the diagnostic tenets are present that include anti-HLA donor specific antibodies (DSA), C4d staining and histological changes centered around the capillary septum. Future studies on pulmonary AMR will be facilitated by the recent publication of a consensus statement on AMR in lung transplantation.

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Acknowledgments

The Alfred’s Lung Transplant Service gratefully acknowledges the Lungitude Foundation for their research and education support.

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Authors and Affiliations

  1. Lung Transplant Service, Alfred Hospital and Monash University, Melbourne, VIC, Australia

    Glen P. Westall & Lucy C. Sullivan

  2. Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia

    Lucy C. Sullivan

Authors
  1. Glen P. Westall
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  2. Lucy C. Sullivan
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Corresponding author

Correspondence to Glen P. Westall .

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Editors and Affiliations

  1. The Lung Transplant Unit, Department of Thoracic Medicine, St Vincent’s Hospital, Sydney, NSW, Australia

    Allan R. Glanville

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Westall, G.P., Sullivan, L.C. (2019). Antibody Mediated Rejection: Are We There Yet?. In: Glanville, A. (eds) Essentials in Lung Transplantation . Springer, Cham. https://doi.org/10.1007/978-3-319-90933-2_7

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  • DOI: https://doi.org/10.1007/978-3-319-90933-2_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90932-5

  • Online ISBN: 978-3-319-90933-2

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