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Radiative transfer of luminescence light in biological tissue

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Light Scattering Reviews 4

Part of the book series: Springer Praxis Books ((ENVIRONSCI))

Abstract

Radiative transfer of light in biological tissue plays a vital part in in vivo biomedical optics. Tissue constitutes a highly scattering and absorbing medium for light at wavelengths of the visible and near-infrared spectrum, and its light-tissue interaction can be exploited not just for therapeutic but also for diagnostic purposes [1–3]. In biomedical optics, light sources are placed on top of the tissue surface, either in contact or non-contact, and illuminate the tissue. Optical images of the reflected or trans-illuminated light are taken, which subsequently provide valuable biomedical information about macroscopic tissue changes. These optically detected tissue changes are mostly based on the absorption contrast that is caused by intrinsic tissue chromophores. The optical contrast of the detected images is, however, relatively poor due to the multiple scattered light inside tissue. Optical imaging has already been utilized in clinical and pre-clinical practice in order to detect these macroscopic tissue changes. Advances have been made in, for example, studying brain function [4,5], optical mammography and detecting breast cancer [6,7], small animal (for example rodents) imaging [8–11], or in detecting the inflammatory progression of rheumatoid arthritis in finger joints [12].

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  1. Department of Radiology, Columbia University, ET351 Mudd Building, MC 8904 500 West 120th Street, New York, NY, 10027, USA

    Alexander D. Klose

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    Alexander A. Kokhanovsky

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Klose, A.D. (2009). Radiative transfer of luminescence light in biological tissue. In: Kokhanovsky, A.A. (eds) Light Scattering Reviews 4. Springer Praxis Books. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74276-0_6

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