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Sol–Gel Carrier System: A Novel Controlled Drug Delivery

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Patenting Nanomedicines

Abstract

In the recent decades, numerous drug delivery systems based on nanoparticles have been developed. To deliver drugs to a specific site, many vehicles have been designed, including liposomes, lipid and polymeric nanoparticles. However these systems can suffer some limitations such as thermal and physical instability as well as opsonization by reticuloendothelial system. This chapter addresses the development and application of silica gel nanoparticles (nanogels) for drug delivery. The synthesis of nanoparticles by sol–gel technology offers new possibilities and many advantages for embedding organic compounds within silica, controlling their release from the host matrix into a surrounding medium, being a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents.

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Acknowledgments

The authors would like to acknowledge the Portuguese Science and Technology Foundation (FCT) under the reference PTDC/SAU-FAR/113100/2009. Ana Luiza R. de Souza was sponsored by CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior). Tatiana Andreani was sponsored by FCT (SFRH/BD/60640/2009).

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Faculty of Health Sciences, UFP, Rua Carlos da Maia, 296, P-4200-150, Porto, Portugal

    Tatiana Andreani & Eliana B. Souto

  2. Department of Biology and Environment, University of Trás-os-Montes e Alto Douro, 1013, 5000-801, Vila real, Portugal

    Tatiana Andreani & Amélia M. Silva

  3. Centre for Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes e Alto Douro (CITAB-UTAD), Vila Real, Portugal

    Tatiana Andreani & Amélia M. Silva

  4. Faculty of Pharmaceutical Sciences, UNESP, Araraquara, Brazil

    Ana Luiza R. de Souza

  5. Institute of Biotechnology and Bioengineering, Centre of Genomics and Biotechnology, University of Trás-os-Montes e Alto Douro (IBB-CGB/UTAD), Vila Real, Portugal

    Eliana B. Souto

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  1. Tatiana Andreani
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  2. Ana Luiza R. de Souza
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Correspondence to Eliana B. Souto .

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    Eliana B. Souto

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Andreani, T., de Souza, A.L.R., Silva, A.M., Souto, E.B. (2012). Sol–Gel Carrier System: A Novel Controlled Drug Delivery. In: Souto, E. (eds) Patenting Nanomedicines. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29265-1_5

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