Skip to main content

Transport of S-100 Protein in Mammalian Nerve Fibers and Transneuronal Signals

  • Conference paper
Symposium on Pathology of Axons and Axonal Flow

Part of the book series: Acta Neuropathologica / Supplementum ((NEUROPATHOLOGIC,volume 5))

Summary

The brain-specific acidic protein S-100 is a migratory protein from soma to terminals of the glossopharyngeal and vagus nerves of rabbit (axonal transport of S-100 protein).

Autoradiographic analyses indicate that certain proteins including probably the S-100 conveyed to the nerve endings of the otic ganglion migrate beyond them, towards the ancillary cells of the axo-dendritic synapses and eventually to the postsynaptic neurons (transynaptic transfer of S-100).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Calissano, P., Moore, B. W., Friesen, A.: Effect of calcium ion on S-100, a protein of the nervous system. Biochemistry 8, 4318–4326 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Cicero, T. J., Cowan, W. M., Moore, B. W., Suntzeff, V.: The cellular localization of the two brain specific proteins, S-100 and 14-3-2. Brain Res. 18, 25–34 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Davis, B. J.: Disc electrophoresis. Ann. N. Y. Acad. Sci. 121, 404–427 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Hyden, H., McEwen, B. S.: A glial protein specific for the nervous system. Proc. nat. Acad. Sci. (Wash.) 55, 354–358 (1966).

    Article  CAS  Google Scholar 

  • Kessler, D., Levine, L., Fasman, G.: Some conformational and immunological properties of a bovine brain acidic protein (S-100). Biochemistry 7, 758–764 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Levine, L., Moore, B. W.: Structural relatedness of a vertebrate brain acidic protein as measured immunochemically. Neurosci. Res. Progr. Bull. 3, 5–11 (1965).

    Google Scholar 

  • Miani, N.: Analysis of the somato-axonal movement of phospholipids in the vagus and hypoglossal nerves. J. Neurochem. 10, 859–874 (1963).

    Article  PubMed  CAS  Google Scholar 

  • — De Renzis, G., Olivieri Sangiacomo, C., Michetti, F., Correr, S., Caniglia, A.: Axonal transport and transynaptic transfer of S-100 protein. (In preparation.)

    Google Scholar 

  • Moore, B. W.: A soluble protein characteristic of the nervous system. Biochem. biophys. Res. Commun. 19, 739–744 (1965).

    Article  PubMed  CAS  Google Scholar 

  • — McGregor: Chromatographic and electrophoretic fractionation of soluble proteins of brain and liver. J. biol. Chem. 240, 1647–1653 (1965).

    PubMed  CAS  Google Scholar 

  • — Perez, V. J.: Complement fixation for antigens on a picogram level. J. Immunol. 96, 1000–1005 (1966).

    PubMed  CAS  Google Scholar 

  • Perez, V. J. — Gehring, M.: Assay and regional distribution of a soluble protein characteristic of the nervous system. J. Neurochem. 15, 265–272 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Perez, V. J., Moore, B. W.: Wallerian degeneration in rabbit tibial nerve: changes in amounts of the S-100 protein. J. Neurochem. 15, 971–977 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Moore, B. W. — Olney, J. W., Cicero, T. J., Moore, B. W., Bahn, B. A.: Wallerian degeneration in rabbit optic nerve: cellular localization in the central nervous system of the S-100 and 14-3-2 proteins. J. Neurochem. 17, 511–519 (1970).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Springer-Verlag

About this paper

Cite this paper

Miani, N. (1971). Transport of S-100 Protein in Mammalian Nerve Fibers and Transneuronal Signals. In: Friede, R.L., Seitelberger, F. (eds) Symposium on Pathology of Axons and Axonal Flow. Acta Neuropathologica / Supplementum, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-47449-1_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-47449-1_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-05433-7

  • Online ISBN: 978-3-642-47449-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics