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Overview of Type 1 and Type 2 AIP

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Autoimmune Pancreatitis

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Abstract

Autoimmune pancreatitis (AIP) is a peculiar form of pancreatitis that has been known for the last two decades. Sarles et al. [1] first reported pancreatitis associated with hypergammaglobulinemia in 1961. They suggested that autoimmunity was one of the etiologies of pancreatitis. The first case that led researchers to suggest a new concept of autoimmune pancreatitis (AIP) was treated with steroids by gastroenterologists (led by Professor Tadashi Takeuchi) in Tokyo Medical Women’s University, and the concept was proposed by Yoshida, a member of that group, in 1995 [2]. The characteristic histological feature of the AIP is lymphoplasmacytic sclerosing pancreatitis (LPSP) [3]. AIP has been increasingly seen over the last decade and is now considered a distinct entity [4, 5]. Based on histological and immunohistochemical examinations of various organs and extrapancreatic lesions of AIP patients, a new clinicopathological entity called “IgG4-related systemic disease” was proposed [4, 6]. AIP is now considered to be a pancreatic manifestation of IgG4-related disease [4, 5, 7].

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Acknowledgment

This study was partially supported by the Intractable Disease, supported by the Ministry of Health, Labour, and Welfare of Japan.

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Authors and Affiliations

  1. Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan

    Terumi Kamisawa MD, PhD

  2. Department of Gastroenterology, Tokyo Medical Women’s University, Tokyo, Japan

    Tadashi Takeuchi MD, PhD & Keiko Shiratori MD, PhD

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  1. Terumi Kamisawa MD, PhD
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  2. Tadashi Takeuchi MD, PhD
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  3. Keiko Shiratori MD, PhD
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Correspondence to Terumi Kamisawa MD, PhD .

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Editors and Affiliations

  1. Department of Internal Medicine, Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan

    Terumi Kamisawa

  2. Department of Internal Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of (South Korea)

    Jae Bock Chung

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Kamisawa, T., Takeuchi, T., Shiratori, K. (2015). Overview of Type 1 and Type 2 AIP. In: Kamisawa, T., Chung, J. (eds) Autoimmune Pancreatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55086-7_1

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  • DOI: https://doi.org/10.1007/978-3-642-55086-7_1

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