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Pax-5/BSAP: Regulator of Specific Gene Expression and Differentiation in B Lymphocytes

  • Chapter
Signal Transduction and the Coordination of B Lymphocyte Development and Function I

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 245/1))

Abstract

The development of B lymphocytes (Fig. 1) from committed precursor cells to antibody-producing plasma cells proceeds through multiple stages defined by the expression of distinct sets of lineage-specific genes (Rolink and Melchers 1996). The early, antigen-independent stages of B-cell differentiation were largely defined by the status of the cell’s immunoglobulin (Ig) genes. In the scheme advanced by Rolink and Melchers (1996), pro-B cells are defined as cells that are committed to the B-cell lineage, but have not yet undergone any Ig gene rearrangements. At the early pre-B cell stage (pre-BI), cells activate their Ig gene recombination machinery including the RAG-1 and RAG-2 genes and commence rearrangements at Ig heavy-chain loci. Heavy-chain polypeptides associate with surrogate light chains encoded by the VpreB and λ5 genes and accessory polypeptides encoded by the mb-1 (Igα/CD79a) and B29 (Igβ/CD79b) genes to assemble the pre-B cell receptor (pre-BCR) on the plasma membrane. Following the productive rearrangement of κ or λ, light chain gene loci, mature membrane-bound Ig (mIg) appears on the plasma membrane of immature B cells as the B-cell receptor (BCR) for antigen. Encounter of specific antigen by a B cell results in intracellular signaling events that can promote further differentiation, including Ig heavy-chain class switch recombination, somatic hypermutation of Ig variable-region genes, and receptor editing. Ultimately, B cells can terminally differentiate to become plasma cells, which do not express Ig on the cell surface and secrete large quantities of antibody.

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Authors and Affiliations

  1. Division of Basic Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, K516, Denver, CO, 80206, USA

    J. Hagman, W. Wheat, D. Fitzsimmons, W. Hodsdon, J. Negri & F. Dizon

  2. Department of Immunology, University of Colorado Health Sciences Center, Denver, CO, 80262, USA

    J. Hagman & D. Fitzsimmons

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  1. J. Hagman
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  2. W. Wheat
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  3. D. Fitzsimmons
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  4. W. Hodsdon
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  5. J. Negri
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  6. F. Dizon
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Editors and Affiliations

  1. Division of Developmental & Clinical Immunology Department of Microbiology, University of Alabama at Birmingham, 378 Wallace Tumor Institute, Birmingham, AL, 35492-3300, USA

    Louis B. Justement Ph.D. (Associate Professor) (Associate Professor)

  2. Department of Medicine, University of Toronto Mount Sinai Hospital, 600 University Ave., Rm. 656A, M5G IX5, Toronto, Ontario, Canada

    Katherine A. Siminovitch M.D.

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Hagman, J., Wheat, W., Fitzsimmons, D., Hodsdon, W., Negri, J., Dizon, F. (2000). Pax-5/BSAP: Regulator of Specific Gene Expression and Differentiation in B Lymphocytes. In: Justement, L.B., Siminovitch, K.A. (eds) Signal Transduction and the Coordination of B Lymphocyte Development and Function I. Current Topics in Microbiology and Immunology, vol 245/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57066-7_5

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