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Genetics of Renal Cell Carcinoma

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Carcinoma of the Kidney and Testis, and Rare Urologic Malignancies

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The classification of renal cell carcinomas is still a matter of debate. The World Health Organization (WHO) nomenclature subdivided renal tumors into adenomas, carcinomas (with and without papillary growth pattern), and others (Murphy et al. 1994). A new refined classification of renal cell tumors was suggested by Thoenes et al. (1986), based not on the growth pattern but on the cell type from which they are derived in different parts of the tubules. Five basic tumor cell types can thus be distinguished: clear and chromophilic cells derived from the proximal tubules; chromophobe and oncocytic cells derived from the cortical connecting tubules and Bellini duct cells derived from the medullary connecting duct. Variants can be assigned to all these basic cells, resulting from an accumulation of mitochondria (eosinophilic variants). An ultimate form of dedifferentiation may occur when spindle cells (sarcomatoid transformation) are present in a smaller or greater part of a tumor together with any of the basic cell subtypes (carcinomatous area). In 1995, two new subtypes were introduced, neuroendocrine renal cell carcinoma and metanephric adenomas (Storkel and van den Berg 1995).

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Authors and Affiliations

  1. Center for Human Genetics, University Hospitals Gasthuisberg, Catholic University of Leuven, Herestraat 49, B-3000, Leuven, Belgium

    P. Dal Cin PhD & H. Van Den Berghe PhD (Professor and Chairman)

Authors
  1. P. Dal Cin PhD
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  2. H. Van Den Berghe PhD
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Editors and Affiliations

  1. Department of Radiation Oncology Kenneth Norris Jr. Cancer Hospital and Research Institute, University of Southern California School of Medicine, 1441 Eastlake Avenue, 90033-004, Los Angeles, CA, USA

    Zbigniew Petrovich MD, FACR (Professor of Radiation Oncology and Urology Chairman) (Professor of Radiation Oncology and Urology Chairman)

  2. Department of Urology, Catholic University of Leuven, University Hospitals Gasthuisberg, 49, Herestraat, B-3000, Leuven, Belgium

    Luc Baert MD, PhD (Professor and Chairman) (Professor and Chairman)

  3. Hylda Cohn/American Cancer Society, USA

    Luther W. Brady MD (Professor of Clinical Oncology, and Professor) (Professor of Clinical Oncology, and Professor)

  4. Department of Radiation Oncology, Allegheny University of the Health Sciences Allegheny University Hospitals, Hahnemann Broad & Vine Sts., Mail Stop 200, Philadelphia, PA, 19102-1192, USA

    Luther W. Brady MD (Professor of Clinical Oncology, and Professor) (Professor of Clinical Oncology, and Professor)

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© 1999 Springer-Verlag Berlin Heidelberg

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Dal Cin, P., Van Den Berghe, H. (1999). Genetics of Renal Cell Carcinoma. In: Petrovich, Z., Baert, L., Brady, L.W. (eds) Carcinoma of the Kidney and Testis, and Rare Urologic Malignancies. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59839-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-59839-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64144-2

  • Online ISBN: 978-3-642-59839-5

  • eBook Packages: Springer Book Archive

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