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Antibody-Mediated Protection of Mucosal Surfaces

  • Chapter
Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 236))

Abstract

Mucosal surfaces of the oral cavity, the digestive and urogenital tracts, and the airways are protected against environmental pathogens by innate and adaptive immune defense mechanisms. Innate defense involves physical, chemical and cellular factors. Entrapment of pathogens in mucus facilitates their clearance by peristalsis in the gut and ciliary movement in the airways. The longitudinal flow of fluids across the epithelial layer mediated by chloride channels helps to flush away microorganisms and prevent their attachment to the epithelial cell surface. The apical cell surface-associated glycocalyx, which consists of a dense network of glycoproteins, also limits the access of pathogens to the epithelial surface. Chemical factors (lysozyme, lactoferrin, peroxidase and defensins) secreted by specialized epithelial cells, such as the Paneth cells in the crypts of the small intestine, gastric acid and intestinal hydrolases (proteases, lipases, nucleases) constitute an efficient defense mechanism.

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Authors and Affiliations

  1. Division of Immunology and Allergology, Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Switzerland

    B. Corthesy

  2. Swiss Institute for Cancer Research and Institute of Biochemistry, University of Lausanne, 1066, Epalinges, Switzerland

    J.-P. Kraehenbuhl

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  1. B. Corthesy
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  2. J.-P. Kraehenbuhl
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Editors and Affiliations

  1. Swiss Institute for Experimental Cancer Research Institute of Biochemistry, University of Lausanne, Ch. des Boveresses 155, CH-1066, Epalinges, Switzerland

    Jean-Pierre Kraehenbuhl

  2. GI Cell Biology Laboratory, Children’s Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA

    Marian R. Neutra

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© 1999 Springer-Verlag Berlin Heidelberg

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Corthesy, B., Kraehenbuhl, JP. (1999). Antibody-Mediated Protection of Mucosal Surfaces. In: Kraehenbuhl, JP., Neutra, M.R. (eds) Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines. Current Topics in Microbiology and Immunology, vol 236. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59951-4_6

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  • DOI: https://doi.org/10.1007/978-3-642-59951-4_6

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