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Structure and Function of Vascular Endothelial Growth Factor Receptor-1 and -2

  • Chapter
Vascular Growth Factors and Angiogenesis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 237))

Abstract

Receptor-type tyrosine kinases are known to be involved in a wide variety of biological processes, such as cell growth, differentiation, morphogenesis and malignant transformation. The endothelial cell-specific growth factors, denoted vascular endothelial growth factors/vascular permeability factors (VEGF/VPF), constitute a growing family of factors that bind to at least three different receptor-type tyrosine kinases (Fig. 1). A wealth of data indicates the important functions of these receptors in the normal development and for physiological and pathological angiogenesis. This review will focus on the structure and function of two of these receptors which, in many respects, are similar to other receptor-type tyrosine kinases. Thus, the VEGF receptors appear to dimerize in response to growth factor binding, become activated, tyrosine phosphorylated and couple to downstream signal transduction chains, much like other growth factor receptors. We aim to outline these similarities, but also to highlight the unique characteristics of the VEGF receptors, which are the key to our understanding of the critical roles of these receptors in fundamental biological processes.

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Authors and Affiliations

  1. Dept. of Genetics, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minatu-ku, Tokyo, 108, Japan

    M. Shibuya

  2. Dept. of Medical Biochemistry and Microbiology, Biomedical Center, Box 575, Uppsala, S-751 23, Sweden

    N. Ito & L. Claesson-Welsh

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  1. M. Shibuya
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  2. N. Ito
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  3. L. Claesson-Welsh
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  1. Department of Medical Biochemistry and Microbiology Biomedical Center, University of Uppsala, Box 575, Uppsala, S-75123, Sweden

    Lena Claesson-Welsh

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Shibuya, M., Ito, N., Claesson-Welsh, L. (1999). Structure and Function of Vascular Endothelial Growth Factor Receptor-1 and -2. In: Claesson-Welsh, L. (eds) Vascular Growth Factors and Angiogenesis. Current Topics in Microbiology and Immunology, vol 237. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59953-8_4

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