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Role of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptors in Vascular Development

  • Chapter
Vascular Growth Factors and Angiogenesis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 237))

Abstract

Distinct cellular processes mediate blood-vessel formation during embryogenesis (Beck and D’Amore 1997; Carmeliet and Collen 1998a; Folkman and D’Amore 1996; Noden 1989; Risau 1997; Wilting and Christ 1996) (Fig. 1). Initially, mesodermal cells differentiate in situ into early haemangioblasts and form cellular aggregates (blood islands), in which the inner-cell population develops into haematopoietic precursors and the outer-cell population gives rise to the primitive endothelial cells. In vitro findings suggest that basic fibroblast growth factor (bFGF or FGF2) may participate in angioblast differentiation via induction of a cellular receptor for vascular endothelial growth factor (VEGF-A) (Flamme and Risau 1992).

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  1. Center for Transgene Technology and Gene Therapy, Campus Gasthuisberg, Herestraat 49, Flanders, USA

    P. Carmeliet & D. Collen

  2. Interuniversity Institute for Biotechnology, University of Leuven, KU Leuven, Leuven, 3000, Belgium

    P. Carmeliet & D. Collen

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  1. Department of Medical Biochemistry and Microbiology Biomedical Center, University of Uppsala, Box 575, Uppsala, S-75123, Sweden

    Lena Claesson-Welsh

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Carmeliet, P., Collen, D. (1999). Role of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptors in Vascular Development. In: Claesson-Welsh, L. (eds) Vascular Growth Factors and Angiogenesis. Current Topics in Microbiology and Immunology, vol 237. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59953-8_7

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