Abstract
During the past twelve years, our laboratory has been analyzing the tumorigenic potential of oncogenes in the lymphoid system of transgenic mice (for reviews see Adams and Cory 1991, 1992). Tissue specific expression of the oncogenes in these animals was achieved by including in the transgene constructs an enhancer sequence (Eμ) from the mouse immunoglobulin heavy chain locus. In most individual strains resulting from the introduction of such constructs, expression was confined to the B lymphoid lineage while a small minority of strains showed expression in both T and B lineages or only in T cells. The pattern for each strain has proved to be stable over many generations of breeding.
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References
Adams JM, Cory S (1991) Transgenic models of tumor development. Science 254:1161–1167
Adams JM, Cory S (1992) Oncogene cooperation in leukemogenesis. Cancer Surv 15:119–141
Barlow DP (1995) Gametic imprinting in mammals. Science 270:1610–1613
Cory S (1995) Regulation of lymphocyte survival by the bcl-2 gene family. Annu Rev Immunol 13:513–543
Cumano A, Paige CJ, Iscove NN, Brady G (1992) Bipotential precursors of B cells and macrophages in murine fetal liver. Nature 356:612–615
de Jong D, Voetdijk MH, Beverstock GC, van Ommen GJB, Willemze R, Kluin PM (1988) Activation of the c-myc oncogene in a precursor-B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma. New Engl J Med 318:1373–1378
Harris AW, Bath ML, Rosenbaum H, McNeall J, Adams JM, Cory S (1990) Lymphoid tumorigenesis by v-abl and BCR-v-abl in transgenic mice. Curr Top Microbiol Immunol 166:165–173
Harris AW (1991) Untitled. In: Mechanisms of B Cell Neoplasia 1991, Roche, Basel, pp 367–372
Harris AW (1993) Untitled. In: Mechanisms of B Cell Neoplasia 1993, Roche, Basel, pp 371–374
Kee BL, Paige CJ (1996) In vitro tracking of IL-7 responsiveness and gene expression during commitment of bipotent B-cell/macrophage progenitors. Curr Biol 6:1159–1169
Korsmeyer SJ (1995) Regulators of cell death. Trends Genet 11:101–105
Langdon WY, Harris AW, Cory S, Adams JM (1986) The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice. Cell 47:11–18
Limpens J, Stad R, Vos C, de Vlaam C, de Jong D, van Ommen G-JB, Schuuring E, Kluin PM (1995) Lymphoma-associated translocation t(14;18) in blood B cells of normal individuals. Blood 85:2528–2536
Linette GP, Hess JL, Sentman CL, Korsmeyer SJ (1995) Peripheral T-cell lymphoma in lck pr -bcl-2 transgenic mice. Blood 86:1255–1260
McDonnell TJ, Korsmeyer SJ (1991) Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18). Nature 349:254–256
Mock BA, Krall MM, Dosik JK (1993) Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis. Proc Natl Acad Sci USA 90:9499–9503
Ohno S, Migita S, Weiner F, Babonits M, Klein G, Mushinski JF, Potter M (1984) Chromosomal translocations activating myc sequences and transduction of v-abl are critical events in the rapid induction of plasmacytomas by pristane and Abelson virus. J Exp Med 159:1762–1777
Potter M, Pumphrey JG, Bailey DW (1975) Genetics of susceptibility to plasmacytoma induction. I. BALB/cAnN (C), C57BL/6N (B6), C57BL/Ka (BK), (C × B6)F1, (C × BK)F1, and C × B recombinant-inbred strains. J Natl Cancer Inst 54:1413–1417
Rolink A, ten Boekel E, Melchers F, Fearon DT, Krop I, Andersson J (1996) A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. J Exp Med 183:187–194
Rosenberg N, Witte ON (1988) The viral and cellular forms of the Abelson (abl) oncogene. Adv Virus Res 35:39–81
Rosenbaum H, Harris AW, Bath ML, McNeall J, Webb E, Adams JM, Cory S (1990) An Eμ-v-abl transgene elicits plasmacytomas in concert with an activated myc gene. EMBO J 9:897–905
Sidman C, Marshall JD, Harris AW (1988) Genetic studies on Eμ-myc transgenic mice. Curr Top Microbiol Immunol 141:94–99
Strasser A, Harris AW, Bath ML, Cory S (1990) Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 348: 331–333
Strasser A, Whittingham S, Vaux DL, Bath ML, Adams JM, Cory S, Harris AW (1991) Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Nad Acad Sci USA 88:8661–8665
Strasser A, Harris AW, Cory S (1993) Eμ-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not B cells. Oncogene 8:1–9
Strasser A, Elefanty AG, Harris AW, Cory S (1996) Progenitor tumours from Eμ-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival. EMBO J 15: 3823–3834
Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM (1984) Cloning of the chromosome breakpoint of neoplastic B cells with the t(14; 18) chromosome translocation. Science 226:1097–1099
Vaux DL, Cory S, Adams JM (1988) bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440–442
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Harris, A.W., Strasser, A., Bath, M.L., Elefanty, A.G., Cory, S. (1997). Lymphomas and Plasmacytomas in Transgenic Mice Involving Bcl2, Myc and v-Abl . In: Potter, M., Melchers, F. (eds) C-Myc in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 224. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60801-8_22
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DOI: https://doi.org/10.1007/978-3-642-60801-8_22
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