Abstract
Vitamin A, which maintains cellular differentiation of epithelial tissues, also has an effect on metaplastic and neoplastic lesions in the respiratory tract. The surface morphology of hamster tracheal epithelium during vitamin A deficiency and during reversal upon the administration of vitamin A was studied by scanning electron microscopy. Focal squamous metaplasia of the tracheal epithelium, confined upon the upper two thirds of the ventral surface of the trachea, occurs in vitamin A deficiency. Synchronous differentiation of the epithelium with sloughing of the existing surface occurs after reversal of the deficient state. This change is rapid, occurring within 4 days of the administration of vitamin A. The SEM enabled documentation of extent distribution and surface changes in vitamin A deficiency and reversal.
This work was performed in part under Contract No. NIH-NCI-72-3292, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health.
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© 1974 Springer-Verlag Berlin · Heidelberg
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Port, C.D., Baxter, D.W., Harris, C.C. (1974). Surface Morphology of Tracheal Epithelium in Vitamin A Deficiency and Reversal. In: Karbe, E., Park, J.F. (eds) Experimental Lung Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61939-7_24
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DOI: https://doi.org/10.1007/978-3-642-61939-7_24
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