Abstract
Hamster-adapted A/PR/8 influenza virus infection followed by a secondary insult consisting of 0.25 ml of 0.5% gelatin-saline instilled directly into the trachea causes epithelial hyperplasia of both the trachea and lung. The extent of the response is related to, and dependent upon, the time interval between virus infection and gelatin-saline administration; the optimal time interval is between 12 and 18 hr. The presence of hyperplasia was measured by 3H-thymidine incorporation. Hyperplasia of the trachea is first apparent 3 days after virus infection, peaks at the fourth day, and is no longer present by the twentieth day. Hyperplasia in the lung begins 4 days after virus infection, peaks at the sixth day, and is undetectable by the twentieth day. Additional studies are in progress to determine the effect of virus-induced hyperplasia on benzo(a)pyrene-ferric oxide initiated respiratory carcinogenesis.
This work was performed in part under Contract No. NIH-NCI-72-3292, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health.
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© 1974 Springer-Verlag Berlin · Heidelberg
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Port, C.D., Baxter, D.W., Kaufman, D.G., Genta, V. (1974). Influenza-Virus-Induced Hyperplasia of the Respiratory Tract of the Hamster. In: Karbe, E., Park, J.F. (eds) Experimental Lung Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61939-7_26
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DOI: https://doi.org/10.1007/978-3-642-61939-7_26
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