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The Genus Yersinia: Biochemistry and Genetics of Virulence With 3 Figures

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Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 57))

Abstract

A highly successful modus operandi in research is to perform an experiment and then decide what problem was solved; the alternative procedure of devising experiments in order to answer preexisting questions may be more difficult. Unfortunately, the latter approach cannot be avoided by those concerned with infectious diseases because the question of why a given microorganism is virulent is automatically framed by its discoverer—in this case, the plague bacillus by Yersin (1894) and the causative agent of pseudotuberculosis by Malassez, and Vignal (1883). The delay of almost a century in obtaining satisfactory answers to these questions simply illustrates that the complexity of the host-parasite relationship is formidable and that experiments relevant to the expression of virulence have not been designed. At the same time, considerable progress towards this end has been made with other pathogens, especially in correlating nutritional requirements and metabolic patterns with the bacterium’s favored habitat in vivo (Moulder, 1962). Nevertheless, the diverse phenomena observed during infection with intracellular parasites cannot always be duplicated in simplified experimental systems. Furthermore, the infectivity of many microorganisms is low or erratic in laboratory animals and the response of the normal host to acute and chronic phases of disease may be quite distinct.

“In the autumn of 1665 the spread of the Great Plague caused the closing of the University until the spring of 1667. During those 18 months Newton (sent home from Cambridge) laid the foundations for his famous discoveries in mathematics and physical science.” Encyclopedia Britannica, 1970 Edition

The preparation of this review was supported by United States PHS grant AI 08468 from the National Institute of Allergy and Infectious Diseases and by the Michigan Agricultural Experiment Station (Article No. 5398).

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  1. Department of Microbiology and Public Health, Michigan State University, East Lansing, Michigan, USA, 48823

    Robert R. Brubaker

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    W. Arber  & N. K. Jerne  & 

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Brubaker, R.R. (1972). The Genus Yersinia: Biochemistry and Genetics of Virulence With 3 Figures. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65297-4_4

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