Abstract
Most cells appear to possess several repair mechanisms capable of removing the damage produced in their DNA by mutagens such as γ-rays, ultraviolet (UV) light, and mitomycin C. The most widely studied of these is that involving excision of the damage and patching of the DNA by repair synthesis (Howard-Flanders, 1973). However, it is now known that other systems of repair involve a process of recombination. In particular, this second type of mechanism is necessary for the repair of damage involving both strands of the DNA molecule. Such damage occurs, for example, when UV-irradiated cells replicate their DNA and gaps are left in the newly synthesized strand opposite pyrimidine dimers in the old strand, or when cells are treated with mitomycin C, an agent that causes cross links to be formed between the two strands (Iyer and Szybalski, 1963). Genetic recombination is greatly stimulated by agents causing this type of damage.
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Moore, P.D. (1976). Detection of Hybrid DNA Formed during Mitomycin C-Induced Sister Chromatid Exchange in Chinese Hamster Cells. In: Kiefer, J. (eds) Radiation and Cellular Control Processes. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66455-7_26
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DOI: https://doi.org/10.1007/978-3-642-66455-7_26
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