Abstract
In our view the central lesion in oncogenesis is the sustained, apparently uncontrolled proliferation of malignant cells beyond the regulated number of their normal counterparts. In general, therefore, the properties of cancer cells are most similar to those of the proliferating stem cells of that particular tissue or cell type. Thus in this view malignant cells do not differ in kind from normal cells, but mainly in the size of their proliferative compartments. Given this point of view, it is logical to assume that malignant cells utilize normal mitogenic pathways for their sustained proliferation and that one must look to means by which a particular class of cells controls its proliferation if one wishes to understand how malignancy is controlled in that cell type.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baird S, Raschke W, Weissman IL (1977) Evidence that MuLV-induced thymic lymphoma cells possess specific cell membrane binding sites for MuLV. Int J Cancer 19:403
Decleve A, Travis M, Weissman IL, Lieberman M, Kaplan HS (1975) Focal infection and transformation in situ of thymus cell subclasses by a thymotropic murine leukemia virus (RadLV). Cancer Res 35:3585
Hollander N, Pillemer E, Weissman IL (1980) The blocking effect of Lyt-2 antibodies on T-cell functions. J Exp Med 152:674
Hollander N, Pillemer E, Weissman IL (1981) Effects of Lyt antibodies on T-cell functions: augmentation by anti Lyt-1 as opposed to inhibition by anti Lyt-2 (mixed lymphocyte reaction/T cell receptor/T cell growth factors). Proc Natl Acad Sci 78:1148
Kotzin S, Strober S (1980) Role of the spleen in the growth of a murine B cell leukemia. Science 208:59
McGrath MS, Weissman IL (1978) A receptor mediated model of viral leukemogenesis: hypothesis and experiments. Cold Spring Harbor meeting on differentiation of normal and neoplastic hematopoietic cells. Hematopoietic mechanisms, pp 577–589
McGrath MS, Weissman IL (1979) AKR leukemogenesis: identification and biological significance of thymic lymphoma receptors for AKR retrovirus. Cell 17:65
McGrath MS, Weissman IL, Baird S, Raschke W, Decleve A, Lieberman M, Kaplan HS (1978a) Each T-cell lymphoma induced by a particular murine leukemia virus bears surface receptors for that virus. Birth Defects 14:349
McGrath MS, Decleve A, Lieberman MN, Kaplan HS, Weissman IL (1978b) Specificity of cell surface virus receptors on radiation leukemia virus and radiation-induced thymic lymphomas. J Virol 28:819
McGrath MS, Pillemer E, Kooistra DA, Jacobs S, Jerabek L, Weissman IL (1980a) T- lymphoma retroviral receptors and control of T-lymphoma cell proliferation. Cold Spring Harbor Symp Quant Biol 44:1297
McGrath MS, Pillemer E, Kooistra D, Weissman IL (1980b) The role of MuLV receptors on T lymphoma cells in lymphoma cell proliferation. Contemp Top Immunobiol 11:157–184
McGrath MS, Pillemer E, Weissman IL (1980c) Murine leukemogenesis: monoclonal antibodies to T cell determinants which arrest T lymphoma cell proliferation. Nature 285:259
McGrath MS, Jerabek L, Pillemer E, Steinberg RA, Weissman IL (1981) Receptor mediated murine leukemogenesis: Monoclonal antibody induced lymphoma cell growth arrest. In: Neth R, Gallo C, Graf T, Mannweiler K, Winkler (eds) Modern trends in human leukemia. IV. Springer, Berlin Heidelberg New York, pp 360–364
Pedersen F, Crowther RL, Tenney DY, Reimold AM, Haseltine WA (1981) Novel leukemogenic retroviruses isolated from cell line derived from spontaneous AKR tumor. Nature 292:167
Severinson EG, Doss CA, Howard FD, Morrison DC, Strober S (1980) Development of an in vitro line of the B cell tumor BCL1 and its responsiveness to polyclonal B cell activators. J Immunol 125:976
Slavin S, Strober S (1978) Spontaneous murine B cell leukemia. Nature 272:624
Warnke RA, Slavin S, Coffman RL, Butcher EC, Knapp MR, Strober S, Weissman IL (1979) The pathology and homing of a transplantable murine B cell leukemia (BCL1). J Immunol 123:1181
Weissman IL, Baird S (1977) Oncornavirus leukemogenesis as a model for selective neoplastic transformation. In: Koprowski H (ed) Neoplastic transformation: mechanisms and consequences. Dahlem Konferenzen, Berlin, Life Science Research Report 7:135
Weissman IL, Baird S, Gardner RL, Papaioannou VE, Raschke W (1977) Normal and neoplastic maturation of T-Tineage lymphocytes. I. II. III. Cold Spring Harbor Symp Quant Biol 41:9
Witte ON, Tsukamoto-Adey A, Weissman IL (1977) Cellular maturation of oncornavirus glyco-proteins: topological arrangement of precursors and product forms in cellular membranes. Virology 76:539
Zeilinski CZ, Waksal SD, Temnpelis L, Khiroya R, Schwartz RS (1980) Surface phenotypes in T cell leukemia are determined by oncogenic retrovirus. Nature 288:489
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Weissman, I.L., McGrath, M.S. (1982). Retrovirus Lymphomagenesis: Relationship of Normal Immune Receptors to Malignant Cell Proliferation. In: Wecker, E., Horak, I. (eds) Retrovirus Genes in Lymphocyte Function and Growth. Current Topics in Microbiology and Immunology, vol 98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68369-5_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-68369-5_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68371-8
Online ISBN: 978-3-642-68369-5
eBook Packages: Springer Book Archive