Abstract
The proliferation and differentiation of normal granulocyte-macrophage (GM) progenitor cells is dependent on the presence of GM colony stimulating factor (GM-CSF). The proliferation of primary leukemic cells is also dependent on GMCSF, and some established myelomonocytic cell lines (e.g., WEHI3B D+) can be induced to differentiate by G-CSF.
The work at the Walter and Eliza Hall Institute was supported in part by Grants from the Anti-Cancer Council of Victoria, the J. D. and L. Harris Fund, the National Health and Medical Research Council, Canberra, the National Cancer Institute, Washington, through Grant No. CA22556-04, and the Australian Government Postgraduate Research Scholarships (PCC and IRS)
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bonner WM, Laskey RA (1974) A film detection method for tritium-labeled proteins and nucleic acids in polyacrylamide gels. Eur J Biochem 46: 83
Bradley TR, Stanley ER, Sumner MA (1971) Factors from mouse tissues stimulating colony growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci 49:595
Burgess AW, Metcalf D (1980) Characterization of a serum factor stimulating the differentiation of myelomonocytic leukemic cells. Int J Cancer 29:647
Burgess AW, Camakaris J, Metcalf D (1977) Purification and properties of colony-stimulating factor from mouse lung conditioned medium. J Biol Chem 252:1998
Burgess A W, Metcalf D, Russell SHM, Nicola NA (1980) Granulocyte/macrophage; megakaryocyte-, eosinophil- and erythroidcolony-stimulating factors produced by mouse spleen cells. Biochem J 185:301
Cooper PC, Metcalf D, Burgess AW (1982) Biochemical and functional characterization of mature progeny purified from a myelomonocytic leukemia. Leukemia Res 6:313
Laemmli UK, Favre M (1973) Maturation of the Head of Bacteriophage T4 I DNA packaging events. J Mol Biol 80:575
Liebermann D, Hoffman-Liebermann B, Sachs L (1980) Molecular dissection of differentiation in normal and leukemic myeloblasts: Separately programmed pathways of gene expression. Dev Biol 79:46
Metcalf D (1979) Clonal analysis of the action of GM-CSF on the proliferation and differentiation of myelomonocytic leukemic cells. Int J Cancer 24:616
Metcalf D (1982) Early events in the suppression of myeloid leukemic cells by biological regulators. In: this volume
Nicola NA, Metcalf D, von Melchner H, Burgess AW (1981) Isolation of murine fetal hemopoietic progenitor cells and selective fractionation of various erythroid precursors. Blood 58:376
O’Farrell PH (1978) High resolution two-dimensional electrophoresis of proteins. J Biol Chem 250:4007
Parker JW, Metcalf D (1974) Production of colony-stimulating factor in mitogen-stimulated lymphocyte cultures. J Immunol 112:502
Stanley ER, Heard PM (1977) Factors regulating macrophage growth and production. J Biol Chem 252:4305
Warner NL, Moore MAS, Metcalf D (1969) A transplantable myelomonocytic leukemia in Balb/c mice: Cytology, karyotype and muramidase content. J Natl Cancer Inst 43:963
Watt SM, Burgess AW (1981) High-resolution two-dimensional electrophoretic analysis of acidic, basic and surface proteins of mouse neutrophils. Biochim Biophys Acta 640:583
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Burgess, A.W., Cooper, P.C., Stanley, I.J., Nicola, N.A. (1983). Effect of Colony-stimulating Factors on the Proteins Synthesized by Normal and Leukemic Myeloid Progenitor Cells. In: Neth, R., Gallo, R.C., Greaves, M.F., Moore, M.A.S., Winkler, K. (eds) Modern Trends in Human Leukemia V. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68761-7_64
Download citation
DOI: https://doi.org/10.1007/978-3-642-68761-7_64
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-11858-9
Online ISBN: 978-3-642-68761-7
eBook Packages: Springer Book Archive