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Cellular Resistance to Cadmium

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Cadmium

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 80))

Abstract

This chapter focuses on the application of cultured cell systems to the study of cellular responses associated with exposure to Cd2+. The scope of this review is limited to considerations of cellular metabolism of Cd2+ and the physiologic and genetic factors that modulate cadmium toxicity. Major emphasis is directed toward three areas: (a) the isolation or derivation of cells differing in Cd2+ cytotoxic response and utilization of such cells to define factors that play a role in cadmium resistance; (b) a consideration of the manifold environmental/physiologic conditions that affect cellular responses in culture; and (c) an evaluation of studies employing somatic cell and molecular genetic techniques to dissect in detail the molecular components of the response mechanisms. The chapter concludes with a discussion of directions and approaches to be pursued in the future to fill gaps in our current understanding of Cd2+ metabolism.

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Authors
  1. M. D. Enger
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  2. C. E. Hildebrand
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  3. J. Seagrave
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  4. R. A. Tobey
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Editor information

Editors and Affiliations

  1. Department of Environment Health(56), University of Cincinnati, College of Medicine, 3223 Eden Avenue, 45267, Cincinnati, OH, USA

    Ernest C. Foulkes Ph.D.

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© 1986 Springer-Verlag Berlin Heidelberg

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Enger, M.D., Hildebrand, C.E., Seagrave, J., Tobey, R.A. (1986). Cellular Resistance to Cadmium. In: Foulkes, E.C. (eds) Cadmium. Handbook of Experimental Pharmacology, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70856-5_11

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  • DOI: https://doi.org/10.1007/978-3-642-70856-5_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70858-9

  • Online ISBN: 978-3-642-70856-5

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