Abstract
Lymphocytic choriomeningitis (LCM) is an inflammatory disease that occurs in immunologically competent adult mice after infection of the brain with LCM virus (LCMV). Tremors develop in the legs, head, and tail, and characteristic extensor spasms of the hind legs are found during the terminal stage of disease, usually within 1 week of infection.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Allan JE, Doherty PC (1985 a) Immune T cells can protect or induce fatal neurological disease in murine lymphocytic choriomeningitis. Cell Immunol 90: 401–407
Allan JE, Doherty PC (1985 b) Consequences of a single Ir-gene defect for the pathogenesis of lymphocytic choriomeningitis. Immunogenetics 21: 581–589
Allan JE, Doherty PC (1985 c) Consequences of cyclophosphamide treatment in murine lymphocytic choriomeningitis: evidence for cytotoxic T cell replication in vivo. Scand J Immunol 22: 367–379
Allan JE, Doherty PC (1986) Natural killer cells contribute to inflammation but do not appear to be essential for the induction of clinical lymphocytic choriomeningitis. Scand J Immunol 24: 153–162
Austyn JM, Gordon S (1981) F4/80: a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol 10: 805–811
Baenziger J, Herngartner H, Zinkernagel RM, Cole GA (1986) Induction or prevention of immuno-pathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus. Eur J Immunol 16: 387–393
Byrne JA, Oldstone MBA (1984) Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo. J Virol 51: 682–686
Buchmeier MJ, Welsh RM, Dutko FJ, Oldstone MBA (1980) The virology and immunobiology of lymphocytic choriomeningitis virus infection. Adv Immunol 30: 275–331
Camenga DL, Walker DH, Murphy FA (1977) Anticonvulsant prolongation of survival in adult murine lymphocytic choriomeningitis. I. Drug treatment and virologic studies. J Neuropathol Exp Neurol 36:9–20
Clark EA, Harmon RC (1980) Genetic control of natural cytotoxicity and hybrid resistance. Adv Cancer Res 31: 227–285
Doherty PC (1973) Quantitative studies of the inflammatory process in fatal viral meningoencephalitis. Am J Pathol 73: 607–622
Doherty PC, Allan JE (1985) Participation of cyclophosphamide-resistant T cells in murine lymphocytic choriomeningitis. Scand J Immunol 21: 127–132
Doherty PC, Allan JE (1986) Hybrid resistance modulates the inflammatory process induced by lymphocytic choriomeningitis virus-immune T cells. Immunology 57: 515–519
Doherty PC, Korngold R (1983) Hierarchies of T cell responsiveness are reflected in the distribution of effector T cells in viral meningitis. Aust J Exp Med SCi 61: 471-475
Doherty PC, Zinkernagel RM (1974) T-cell-mediated immunopathology in viral infections. Transplant Rev 19: 89–120
Doherty PC, Dunlop MBC, Parish CR, Zinkernagel RM (1976) Inflammatory process in murine lymphocytic choriomeningitis is maximal in H-2K or H-2D compatible interactions. J Immunol 117:187–190
Hurwitz JL, Korngold R, Doherty PC (1983) Specific and nonspecific T-cell recruitment in viral meningitis: possible implications for autoimmunity. Cell Immunol 76: 397–401
Johnson ED, Monjan AA, Morse HC III (1978) Lack of B-cell participation in acute lymphocyte choriomeningitis disease of the central nervous system. Cell Immunol 36: 143–150
Lehmann-Grube F (1982) The mouse in biomedical research, vol 2 Diseases. Academic, New York
Longo DL, Schwartz RH (1980) T-cell specificity for H-2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells. Nature 287:44–46
Nathanson N, Monjan AA, Panitch HJ, Johnson ED, Petursson G, Cole GA (1975) Viral immunology and immunopathology. Academic, New York
Orn A, Goodenow RS, Hood L, Brayton PR, Woodward JG, Harmon RC, Frelinger JA (1982) Product of a transferred H-2Ld gene acts as a restriction element for LCMV-specific killer T cells. Nature 297:415–417
Perry VH, Hume DA, Gordon S (1985) Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience 15: 313–326
Schwendemann G, Lohler J, Lehmann-Grube F (1983) Evidence for cytotoxic T-lymphocyte-target cell interaction in brains of mice infected intracerebrally with lymphocytic choriomeningitis virus. Acta Neuropathol (Berl) 61: 183–195
Sprent J, Korngold R (1983) A comparison of lethal graft-vs-host disease to minor-vs-major histocompatibility differences in mice: implications for marrow transplantation in man. Progress in Immunology V: 1461–1475
Thomsen AR, Volkert M, Marker O (1979) The timing of the immune response in relation to virus growth determines the outcome of the LCM infection. Acta Pathol Microbiol Scand [C] 87:47–54
Walker DH, Murphy FA, Whitfield SG, Baver SP (1975) Lymphocytic choriomeningitis: ultrastructural pathology. Exp Mol Pathol 23: 245–265
Zinkernagel RM, Doherty PC (1973) Cytotoxic thymus derived lymphocytes in cerebrospinal fluid of mice with lymphocytic choriomeningitis. J Exp Med 138: 1266–1269
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Allan, J.E., Dixon, J.E., Doherty, P.C. (1987). Nature of the Inflammatory Process in the Central Nervous System of Mice Infected with Lymphocytic Choriomeningitis Virus. In: Oldstone, M.B.A. (eds) Arenaviruses. Current Topics in Microbiology and Immunology, vol 134. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71726-0_6
Download citation
DOI: https://doi.org/10.1007/978-3-642-71726-0_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71728-4
Online ISBN: 978-3-642-71726-0
eBook Packages: Springer Book Archive