Summary
Dual chamber pacemakers have recently come into widespread use. They offer practical advantages in restoring atrio-ventricular synchrony and in allowing rate variability in response to physiologic stresses. Doppler ultrasound allows non-invasive assessment of cardiac output in man. We used this technique to determine the changes in resting cardiac output itt patients with DDD pacemakers when the mode of pacing was varied from VVI to DDD at fixed heart rates.
Doppler ultrasound measurement of cardiac output was first validated with thermodilution measurements in 12 patients recovering from coronary bypass surgery (R = 0.83). Then twenty-seven patients with DDD pacemakers were assessed at rest with the heart rate fixed and the mode of pacing varied from VVI to DDD. There was a significant increase in cardiac output from 4.2 ± 0.4 (mean ± SEM) liters per minute in the VVI mode to 5.0 ± 0.4 in the DDD mode (p < 0.001). The degree of improvement in cardiac output was independent of ventricular function. The percentage increase in cardiac output averaged 16 ± 3% in those 12 patients with left ventricular ejection fraction greater than 40% and 27 ± 8% in those 15 patients with LVEF less than 40% (p = NS).
Substantially greater improvements in cardiac output occurred however, in those patients with evidence of the pacemaker syndrome or intact ventriculo-atrial conduction. In these 9 patients, there was a mean improvement of 39% ± 10% in cardiac output between VVI and DDD as opposed to an average increase of only 14% ± 3% in the 18 patients without VA conduction (p < 0.02). The patients with poor left ventricular function and VA conduction showed the most marked improvements. Thus, Doppler ultrasound can be used to quantitate the improvement in cardiac output which occurs in patients at rest with DDD pacing versus VVI pacing. This improvement is independent of the level of left ventricular function but is substantially higher when there is evidence of VA conduction or the pacemaker syndrome.
Albert S. Hyman Research Fellow in Cardiac Pacing, North American Society of Pacing and Electrophysiology
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References
Folkman MI, Watkins EJ: An artificial conduction system for the management of experimental complete heart block. Surg Forum 1958; 8: 331–334.
Nathan DA, Samet P, Center S, Wu CY: Long term correction of complete heart block. Clinical and physiologic studies of a new type of implantable synchronous pacer. Prog Cardiovas Dis 1964; 6: 538–565.
Light LH: Non-injurious ultrasonic technique for observing flow in the human aorta. Nature 1969; 224: 1119–1121.
Hatle L, Angleson B: Doppler ultrasound in cardiology, physical principles and applications. Lea and Febiger, Philadelphia, 238 pp, 1982.
Brubakk AO, Gisvold SE: Pulsed Doppler ultrasound for measuring blood flow in the human aorta. In Hatle Land Angleson B, op cit, pp 185–193.
Mackay RS: Non-invasive cardiac output measurement. Microvasc Res 1972; 4: 438–452.
Magnin PA, Stewart JA, Myers S, VonRamm O, Kisslo JA: Combined Doppler and phasedarray echocardiographic estimation of cardiac output. Circ 1981; 63: 388–392.
Mitsui T, Mizuno A, Hasegawa T, Kobayashi H, Hori M, Suma K, Laigusa M: Atrial rate as an indicator for optimal pacing rate and the pacemaking syndrome. Ann Cardiol Angeiol 1971; 20: 371–379.
Gesell, RA: Auricular systole and its relation to ventricular output. Am J Physiol 1911; 29: 32–63.
Little, RC: Effect of atrial systole on ventricular pressure and closure of the AV valves. Am J Physiol 1951; 166: 289–295.
Skinner NS, Mitchell JH, Wallace AG, Sarnoff SJ: Hemodynamic effects of altering the timing of atrial systole. Am J Physiol 1963; 205: 499–503.
Gilmore JP, Sarnoff SJ, Mitchell IH, Linden RJ: Synchronicity of ventricular contraction: Observation comparing hemodynamic effects of atrial and ventricular pacing. Brit Heart J 1963; 25: 299–307.
Samet P, Castillo C, Bernstein WH: Hemodynamic consequences of sequential atrioventricular pacing. Subjects with normal hearts. Am J Cardiol 1968; 21: 207–212.
Benchimol A, Duenas A, Liggett NS, Dimond EG: Contribution of atrial systole to the cardiac function at a fixed and at a variable ventricular rate. Am J Cardiol 1965; 16: 11–21.
Braunwald E, Frahm CI: Studies on Starling’s law of the heart. IV. Observations of the hemodynamic functions of the left atrium in man. Circ 1961; 24: 633–642.
Smyth, NPD, Citron P, Keshishian JM, Garcia JM, Kelly LC: Permanent pervenous atrial sensing and pacing with a new I-shaped lead. J Thorac Cardiovasc Surg 1976; 72: 565–570.
Kleinert M, Block M, Wilhemi F: Clinical use of a new transvenous atrial lead. Am J Cardiol 1977;40:237–242.
Schaldach M, Furman S (Eds): Advances in pacemaker technology. Page 55–75. Springer Verlag, New York, Heidelberg, Berlin, 554 pp, 1975.
Parsonnet V, Bernstein AD: Treatment and techniques in transition. J Am Coli Cardiol 1983; 1: 339–354.
Cohen SI, Frank HA: Preservation of active atrial transport: An important clinical consideration in cardiac pacing. Chest 1982; 81: 51–4.
Sutton R, Perrins J, Citron P: Physiologic cardiac pacing. Pace 1980; 3: 207–219.
Goldman B, Curtiss JJ, Madigan NP, Whiting RB, Mueller KJ, Pezzalla AT: Discussion: Clinical experience with permanent atrioventricular sequential pacing. Ann Thorac Surg 1981; 32: 179–187.
Hartzler GO, Maloney ID, Curtis JJ, Barnhorst DA: Hemodynamic benefits of atrioventricular sequential pacing after cardiac surgery: Am J Cardiol 1977; 40: 232–235. 238
Leinbach RC, Chamberlain DA, Kastor JA, Harthome JW, Sanders CA: A comparison of the hemodynamic effects of ventricular and sequential A V pacing in patients with heart block. Am Heart J 1969; 78: 502–508.
Kruse I, Amman K, Conradson TB, Ryden L: A comparison of the acute and long-term hemodynamic effects of ventricular inhibited and atrial synchronous ventricular inhibited pacing. Circulation 1982; 65: 846–855.
Ogawa S, Dreifus LS, Shenoig PN, Brockman SK, Berkovits BV: Hemodynamic consequences of atrioventricular and ventriculo atrial pacing. Pace 1978; 1: 8–15.
Rahimtoola SH, Ehsani A, Sinno MZ, Loeb HS, Rosen KM, Gunnar RM: Left atrial transport function in myocardial infarction. Am J Med 1975; 59: 686–694.
Chamberlain DA, Leinbach RC, Vassaux CE, Kastor JA, DeSanctis RW, Sanders CA: Sequential atrioventricular pacing in heart block complicating acute myocardial infarction. NEJM 1970; 282: 577–582.
Benchimol A, Ellis JG, Dimond EG: Hemodynamic consequences of atrial and ventricular pacing in patients with normal and abnormal hearts. Effect of exercise at a fixed atrial and ventricular rate. Am J Med 1965; 39: 911–922.
Fischer DC, Sahn DJ, Friedman MJ, Larson D, Valdes-Cruz LM, Horowitz S, Goldberg SJ, Allen HD: The mitral valve orifice method for noninvasive two-dimensional echo Doppler determination of cardiac output. Circ 1983; 67: 872–877.
Sanders SP, Yeager S, Williams RG: Measurement of systemic and pulmonary blood flow and QP/QS ratio using Doppler and two-dimensional echocardiography. Am J Card 1983; 51: 952–956.
Steingart RM, Meller J, Barovick J, Patterson R, Herman MV, Teichholz LE: Pulsed Doppler echocardiographic measurement of beat-to-beat changes in stroke volume in dogs. Circ 1980; 62: 542–548.
Colocousis JS, Huntsman LL, Curreri PW: Estimation of stroke volume changes by ultrasonic Doppler. Circ 1977; 56: 914–917.
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© 1983 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt
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Dicola, V.C., Stewart, W.J., Harthorne, J.W., Weyman, A.E. (1983). Doppler Ultrasound Measurement of Cardiac Output in Patients with Physiologic Dual Chamber Pacemakers. In: Steinbach, K. (eds) Cardiac Pacing. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-72367-4_35
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DOI: https://doi.org/10.1007/978-3-642-72367-4_35
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