Abstract
While many pathobiochemical consequences of lipid peroxidation like hepatotoxicity, ageing and artherosclerosis have been described in the literature, no non-destructive biochemical function of lipid peroxidation has been demonstrated unequivocally. A negative association between the extent of lipid peroxidation in tumour cells and their proliferative behaviour has been postulated (Bartoli and Galeotti 1979). Experimental evidence is available in the literature for the following factors, which may contribute to this negative association: (a) Decreased content of polyunsaturated fatty acids, (b) Shift of the balance between pro-oxidant (e. g. iron) and antioxidant (e. g. glutathione) substances to the antioxidant side. (c) decreased activity of peroxidative enzymes (e. g. NADPH-cytochrome c reductase), (d) reduced access of oxygen as a consequence of increased tumour membrane rigidity.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bartoli GM, Galeotti T (1979) Growth-related lipid peroxidation in tumour microsomal membranes and mitochondria. Biochim Biophys Acta 574:537–541
Burton GW, Cheeseman KG, Ingold KU, Blater TF (1983) Lipid antioxidants and products of lipid peroxidation as potential tumour protective agents. Biochem Soc Trans 11:261–262
Cathcart R, Schwiers E, Ames BN (1984) Detection of picomole levels of lipid hydroperoxides using a dichlorofluorescein fluorescent assay. Methods Enzymol 105:352–358
Cornwell DG, Morisaki N (1984) Fatty acid peroxides in the control of cell proliferation: Prostaglandins, lipid feroxides, and cooxidation reactions. In: Pryor WA (ed) Free radicals in biology, vol G. Academic, New York, pp 95–148
Khoschsorur G, Schaur RJ, Schauenstein E, Tillian HM, Reiter M (1981) Intracellular effect of hydroxyalkenals on animal tumors. Z Naturforsch 360:572–578
Schaur RJ, Winkler P, Hayn M, Schauenstein E (1987) Decrease of glutathione and fatty acids during iron-induced lipid peroxidation in Ehrlich ascites tumor cells. Chem Monthly 118:823–830
Winkler P, Schaur RJ, Schauenstein E (1984a) Selective promotion of ferrous ion-dependent lipid peroxidation in Ehrlich ascites tumor cells by histidine as compared with other amino acids. Biochim Biophys Acta 796:226–231
Winkler P, Lindner W, Esterbauer H, Schauenstein E, Schaur RJ, Khoschsorur GA (1984b) Detection of 4-hydroxynonenal as a product of lipid peroxidation in native Ehrlich ascites tumor cells. Biochim Biophys Acta 796-237
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Hammer, A., Tillian, H.M., Kink, E., Sharaf El Din, M., Schaur, R.J., Schauenstein, E. (1988). Iron-Induced Lipid Peroxidation and Inhibition of Proliferation in Animal Tumour Cells. In: Nigam, S.K., McBrien, D.C.H., Slater, T.F. (eds) Eicosanoids, Lipid Peroxidation and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73424-3_24
Download citation
DOI: https://doi.org/10.1007/978-3-642-73424-3_24
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-18932-9
Online ISBN: 978-3-642-73424-3
eBook Packages: Springer Book Archive