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Regulation and Tissue-Specific Expression of Human Cytomegalovirus

  • Conference paper
Cytomegaloviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 154))

Abstract

Human cytomegalovirus (HCMV) establishes a lifelong latent state after primary infection, as do the other members of the human herpesvirus family. The site of latency and the molecular mechanisms involved in the establishment and maintenance of latent virus in the cell are unknown for HCMV. In this chapter, we will discuss experimental approaches to identifying cell types naturally infected in the human host by HCMV. We will examine cell culture systems and transcription factor interactions in vitro which may identify HCMV-host cell interactions that regulate expression of the virus.

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Authors and Affiliations

  1. Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA, 92037, USA

    J. A. Nelson & P. Ghazal

  2. Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    J. W. Gnann Jr.

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  1. J. A. Nelson
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  2. J. W. Gnann Jr.
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  3. P. Ghazal
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Editors and Affiliations

  1. Fred Hutchinson Cancer Research Center, University of Washington, 1124, Columbia Street, Seattle, WA, 98104, USA

    James K. McDougall PhD. (Research Professor of Pathology, Member) (Research Professor of Pathology, Member)

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Nelson, J.A., Gnann, J.W., Ghazal, P. (1990). Regulation and Tissue-Specific Expression of Human Cytomegalovirus. In: McDougall, J.K. (eds) Cytomegaloviruses. Current Topics in Microbiology and Immunology, vol 154. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74980-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-74980-3_4

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