Abstract
From the time of the very earliest studies by Damadian et al. (1973) it was postulated that NMR water proton relaxation times had potential for the diagnosis of cancer. However, this overstated the position and there was subsequent criticism of the approach relating to both the relaxation times themselves (Bottomley et al. 1987) and statistical aspects of the samples (Herbert 1986). Nevertheless, many NMR studies by workers the world over have shown clear discrimination between cancerous and noncancerous tissues, as exemplified by many of the data generated by Ranade and co-workers using in vitro NMR measurements and taking care to provide meaningful controls (Shah et all 982a–c).
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Ranade, S.S., Trivedi, P.N., Bamane, V.S., Lindon, J.C., Livingstone, D.J., Rahr, E. (1990). Proton NMR Relaxation Times and Trace Paramagnetic Metal Contents: Pattern Recognition Analysis of the Discrimination Between Normal and Pathological Tissue of the Gastrointestinal Tract and Bone Marrow. In: Higer, H.P., Bielke, G. (eds) Tissue Characterization in MR Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74993-3_43
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DOI: https://doi.org/10.1007/978-3-642-74993-3_43
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