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Genetic Factors in Rheumatoid Arthritis

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Rheumatoid Arthritis

Abstract

For many years the paradigm for genetic studies in rheumatoid arthritis (RA) has been based around multifactorial determination of susceptibility including an oligo- or polygenic component. Given the massive investment of resources in this field of rheumatology research it is saluatory to consider data which suggest the genetic component may account for as little as 12% of the total variability [1]. Genetic studies, however, should not be dismissed on this basis since the aetiology of RA is unknown. As will be discussed later, fine structural analysis of the HLA-DR4 molecule, the best characterised genetic association, implicates specific immune regulation as a key area in the pathogenesis of RA. The immediate potential of this type of approach is to facilitate the step towards rational experimental design and eventually therapeutic intervention.

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Author information

Authors and Affiliations

  1. Molecular Immunogenetics & Rheumatology Units, UMDS, Guy’s Hospital, London, SE1 9RT, UK

    J. S. S. Lanchbury, L. I. Sakkas & G. S. Panayi

Authors
  1. J. S. S. Lanchbury
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  2. L. I. Sakkas
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  3. G. S. Panayi
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Editor information

Editors and Affiliations

  1. 2. Medizinische Abteilung Zentrum fü Diagnostik und Therapie rheumatischer Erkrankungen, Krankenhaus der Stadt Wien-Lainz und Ludwig Boltzmann Institut für Rheumatologie und Balneologie, Wolkersbergenstraße 1, A-1130, Wien, Austria

    Josef S. Smolen

  2. Medizinische Klinik III mit Poliklinik und Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 12, W-8520, Erlangen, Germany

    Joachim R. Kalden

  3. Mathilda and Terence Kennedy Institute of Rheumatology, 6 Bute Gardens, W6 7DW, Hammersmith, London, UK

    Ravinder N. Maini

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© 1992 Springer-Verlag Berlin Heidelberg

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Lanchbury, J.S.S., Sakkas, L.I., Panayi, G.S. (1992). Genetic Factors in Rheumatoid Arthritis. In: Smolen, J.S., Kalden, J.R., Maini, R.N. (eds) Rheumatoid Arthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76189-8_2

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  • DOI: https://doi.org/10.1007/978-3-642-76189-8_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76191-1

  • Online ISBN: 978-3-642-76189-8

  • eBook Packages: Springer Book Archive

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