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Genetic Transmission of Negative and Positive Symptoms in the Biological Relatives of Schizophrenics

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Negative Versus Positive Schizophrenia

Abstract

Despite strong evidence for the role of genetics in schizophrenia, the nature of the underlying mechanisms remains elusive. Knowledge is limited regardless of recent advances in the statistical analysis of family data and the ability to detect complex segregation patterns in the pedigrees of schizophrenic probands. This has prompted the development of alternative approaches which move beyond the traditional concept of schizophrenia. In this regard, increasing interest has been devoted to the understanding of disorders or traits which may be related to schizophrenia and observed in biological relatives who do not themselves manifest a “full-blown” schizophrenic syndrome. The delineation of the so- called “spectrum disorders” such as schizotypal personality disorder is one example of this approach. It is suggested (Risch and Baron 1984; Tsuang and Faraone 1984) that such traits or disorders may prove to be manifestations of the underlying “schizophrenia gene(s),” with clinical schizophrenia being only one extreme phenotypic expression. If so, these other, more common traits may provide more sensitive indices in genetic analyses. Their identification as alternative schizophrenic phenotypes or “schizotypes” would therefore constitute a significant contribution to the understanding of the mechanisms underlying schizophrenia.

Preparation of this article was supported in part by the Veterans Administration’s Health Services Research and Development Program and National Institute of Mental Health Grants 1 R01MH41879-01 and 1 R37MH43518-01.

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Authors and Affiliations

  1. Harvard Departments of Psychiatry and Epidemiology, Brockton/West Roxbury, VA Medical Center, 940 Belmont Street, Brockton, MA, 02401, USA

    M. T. Tsuang & S. V. Faraone

  2. VA Medical Center, Schizophrenia Research, Center Unit, Highland Drive, Pittsburgh, PA, 15206, USA

    M. W. Gilbertson

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  1. M. T. Tsuang
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  2. M. W. Gilbertson
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  3. S. V. Faraone
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Editors and Affiliations

  1. Psychiatrische Universitätsklinik, Sigmund-Freud-Straße 25, W-5300, Bonn, Germany

    Andreas Marneros

  2. Department of Psychiatry, University of Iowa, 500 Newton Road, Iowa City, IO, 52242, USA

    Nancy C. Andreasen MD., Ph. D.

  3. Harvard Departments of Psychiatry and Epidemiology, Brockton/West Roxbury VA Medical Center, 940 Belmont Street, Brockton, MA, 02401, USA

    Ming T. Tsuang MD., Ph. D., D. Sc.

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Tsuang, M.T., Gilbertson, M.W., Faraone, S.V. (1991). Genetic Transmission of Negative and Positive Symptoms in the Biological Relatives of Schizophrenics. In: Marneros, A., Andreasen, N.C., Tsuang, M.T. (eds) Negative Versus Positive Schizophrenia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76841-5_18

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