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Genetic Diversity and Slow Rates of Evolution in New World Alphaviruses

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Genetic Diversity of RNA Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 176))

Abstract

Alphavirus is a genus of arthropod-borne viruses (arboviruses) in the family Togaviridae. These viruses have a single-strand messenger or plus-sense RNA genome of ca. 11 700 bases. 42S genomic RNA is found in virions and infected cells; a subgenomic 26S RNA species, identical to the 3’-third of the 42S genomic messenger RNA (mRNA), is present only in infected cells and codes only for the structural proteins (Strauss and Strauss 1986; Schlesinger and Schlesinger 1990).

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References

  • Brown DT, Condreay LD (1986) Replication of alphaviruses in mosquito cells. In: Schlesinger S, Schlesinger M (eds) The togaviruses and flaviviruses. Plenum, New York, pp 171–207

    Google Scholar 

  • Calisher CH, Karabatsos N (1988) Arbovirus serogroups: definition and geographic distribution. In: Monath TP (ed) The arboviruses: epidemiology and ecology, vol 1. CRC, Boca Raton, pp 19–57

    Google Scholar 

  • Casals J (1964) Antigenic variants of eastern equine encephalitis virus. J Exp Med 119: 547–565

    Article  PubMed  CAS  Google Scholar 

  • Chamberlain RW, Sudia WD (1957) Dual infections of eastern and western equine encephalitis virus in Culex tarsalis. J Infect Dis 101: 233–236

    Article  PubMed  CAS  Google Scholar 

  • Chang G-JJ, Trent DW (1987) Nucleotide sequence of the genome region encoding the 26S mRNA of eastern equine encephalomyelitis virus and the deduced amino acid sequence of the viral structural proteins. J Gen Virol 68: 2129–2142

    Article  PubMed  CAS  Google Scholar 

  • Coelen RJ, Mackenzie JS (1988) Genetic variation of Murray Valley encephalitis virus. J Gen Virol 69: 1903–1912

    Article  PubMed  Google Scholar 

  • Deubel V, Pailliez JP, Cornet M, Schlesinger JJ, Diop M, Diop A, Digoutte JP, Girard M (1985) Homogeneity among Senegalese strains of yellow fever virus. Am J Trop Med Hyg 34: 976–983

    PubMed  CAS  Google Scholar 

  • Eldridge B (1990) Evolutionary relationships among California serogroup viruses (Bunyaviridae) and Aedes mosquitoes (Diptera: Culicidae). J Med Entomol 27: 738–749

    PubMed  CAS  Google Scholar 

  • Flynn LM, Coelen RJ, Mackenzie JS (1989) Kunjin virus isolates of Australia are genetically homogeneous. J Gen Virol 70: 2819–2824

    Article  PubMed  CAS  Google Scholar 

  • Futuyma DJ (1986) Evolutionary biology. Sinauer, Sunderland

    Google Scholar 

  • Hahn CS, Lustig S, Strauss EG, Strauss JH (1988) Western equine encephalitis virus is a recombinant virus. Proc Nall Acad Sci USA 85: 5997–6001

    Article  CAS  Google Scholar 

  • Hahn CS, Rice CM, Strauss EG, Lenches EM, Strauss JH (1989) Sindbis virus ts103 has a mutation in glycoprotein E2 that leads to defective assembly of virions. J Virol 63: 3459–3465

    PubMed  CAS  Google Scholar 

  • Henderson JR (1964) Immunologic characterization of western equine encephalomyelitis virus strains. J Immunol 93: 452–461

    PubMed  CAS  Google Scholar 

  • Kay BH, Aaskov JG (1988) Ross River virus (epidemic polyarthritis). In: Monath TP (ed) The arboviruses: epidemiology and ecology, vol 4. CRC, Boca Raton, pp 93–112

    Google Scholar 

  • Kew OM, Nottay BK (1984) Evolution of the oral poliovaccine strains in humans occurs by both mutation and intramolecular recombination. In: Canock R, Lerner R (ed) Modern approaches to vaccines. Cold Spring Harbor Laboratory, Cold Spring Harbor, pp 357–362

    Google Scholar 

  • Kielian M, Helenius A (1986) Entry of alphaviruses. In: Schlesinger S, Schlesinger M (eds) The togaviruses and flaviviruses. Plenum, New York, pp 91–119

    Google Scholar 

  • Kinney RM, Trent DW, France JK (1983) Comparative immunological and biochemical analysis of viruses in the Venezuelan equine encephalitis complex. J Gen Virol 64: 135–147

    Article  PubMed  CAS  Google Scholar 

  • Kinney RM, Johnson BJB, Brown VL, Trent DW (1986) Nucleotide sequence of the 26S mRNA of the virulent Trinidad donkey strain of Venezuelan equine encephalitis virus and deduced sequence of the encoded proteins. Virology 152: 400–413

    Article  PubMed  CAS  Google Scholar 

  • Lemm JA, Durbin RK, Stollar V, Rice CM (1990) Mutations which alter the level of nsP4 can affect the efficiency of Sindbis virus replication in a host-dependent manner. J Virol 64: 3001–3011

    PubMed  CAS  Google Scholar 

  • Levinson RS, Strauss JH, Strauss EG (1990) Complete sequence of the genomic RNA of O’nyongnyong virus and its use in the construction of alphavirus phylogenetic trees. Virology 175: 110–123

    Article  PubMed  CAS  Google Scholar 

  • Mitter C, Brooks DR (1983) Phylogenetic aspects of coevolution. In Futuyma DJ, Slatkin M (eds) Coevolution. Sinauer, Sunderland, pp 65–98

    Google Scholar 

  • Morita K, Igarashi A (1984) Oligonucleotide fingerprint analysis of strains of Getah virus isolated in Japan and Malaysia. J Gen Virol 65: 1899–1908

    Article  PubMed  CAS  Google Scholar 

  • Olson K, Trent DW (1985) Genetic and antigenic variations among geographical isolates of Sindbis virus. J Gen Virol 66: 797–810

    Article  PubMed  CAS  Google Scholar 

  • Peters CJ, Dalrymple J (1990) Alphaviruses. In: Fields BN, Knipe DM (eds) Virology, 2nd edn. Raven, New York, pp 713–761

    Google Scholar 

  • Price PW (1980) Evolutionary biology of parasites. Princeton University Press, Princeton

    Google Scholar 

  • Reisen WK, Monath TP (1988) Western equine encephalitis. In: Monath TP (ed) The arboviruses: epidemiology and ecology, vol 1. CRC, Boca Raton, pp 89–137

    Google Scholar 

  • Rico-Hesse R, Pallansch MA, Nottay BK, Kew OM (1987) Geographic distribution of wild poliovirus type 1 genotypes. Virology 160: 311–322

    Article  PubMed  CAS  Google Scholar 

  • Rico-Hesse R, Roehrig JT, Trent DW, Dickerman RW (1988) Genetic variation of Venezuelan equine encephalitis virus strains of the ID variety in Colombia. Am J Trop Med Hyg 38: 195–204

    PubMed  CAS  Google Scholar 

  • Roehrig JT, Mathews JH (1985) The neutralization site on the E2 glycoprotein of Venezuelan equine encephalomyelitis virus is composed of multiple conformationally stable epitopes. Virology 142: 347–356

    Article  PubMed  CAS  Google Scholar 

  • Roehrig JT, Hunt AR, Chang G-J, Sheik B, Bolin RA, Tsai TF, Trent DW (1990) Identification of monoclonal antibodies capable of differentiating antigenic varieties of eastern equine encephalitis viruses. Am J Trop Med Hyg 42: 394–398

    PubMed  CAS  Google Scholar 

  • Rosen L (1987) Overwintering mechanisms of mosquito-borne arboviruses in temperate climates. Am J Trop Med Hyd 37: 695–765

    Google Scholar 

  • Schlesinger S, Schlesinger MJ (1990) Replication of togaviridae and flaviviridae. In: Fields BN, Knipe DM (eds) Virology, 2nd edn. Raven, New York, pp 697–711

    Google Scholar 

  • Scott TW (1988) Vertebrate host ecology. In: Monath TP (ed) The arboviruses: epidemiology and ecology, vol 1. CRC, Boca Raton, pp 257–280

    Google Scholar 

  • Scott TW, Weaver SC (1989) Eastern equine encephalomyelitis virus: epidemiology and evolution of mosquito transmission. Adv Virus Res 37: 277–328

    Article  PubMed  CAS  Google Scholar 

  • Slatkin M (1987) Gene flow and the geographic structure of natural populations. Science 236: 787–792

    Article  PubMed  CAS  Google Scholar 

  • Steinhauer DA, Holland JJ (1987) Rapid evolution of RNA viruses. Annu Rev Microbiol 41: 409–433

    Article  PubMed  CAS  Google Scholar 

  • Strauss EG, Strauss JH (1986) Structure and replication of the alphavirus genome. In: Schlesinger S, Schlesinger M (eds) The togaviruses and flaviviruses. Plenum, New York, pp 35–90

    Google Scholar 

  • Trent DW, Grant JA (1980) A comparison of New World alphaviruses in the western equine encephalitis virus complex by immunochemical and oligonucleotide fingerprint techniques. J Gen Virol 47: 261–282

    Article  PubMed  CAS  Google Scholar 

  • Trent DW, Clewey JP, France JK, Bishop DHL (1979) Immunochemical and oligonucleotide fingerprint analysis of Venezuelan equine encephalomyelitis complex viruses. J Gen Virof 43: 365–381

    Article  CAS  Google Scholar 

  • Trent DW, Grant JA, Vorndam AV, Monath TP (1981) Genetic heterogeneity among Saint Louis encephalitis virus isolates of different geographic origin. Virology 114: 319–332

    Article  PubMed  CAS  Google Scholar 

  • Trent DW, Grant JA, Monath TP, Manske CL, Corina M, Fox GE (1989) Genetic variation and microevolution of dengue 2 virus in southeast Asia. Virology 172: 523–535

    Article  PubMed  CAS  Google Scholar 

  • Walton TE, Grayson MA (1988) Venezuelan equine encephalomyelitis. In: Monath TP (ed) The arboviruses: epidemiology and ecology, vol 1. CRC, Boca Raton, pp 59–85

    Google Scholar 

  • Weaver SC, Scherer WF, Cupp EW, Castello DA (1984) Barriers to dissemination of Venezuelan encephalitis viruses in the Middle American enzootic vector mosquito, Culex (Melanoconion) taenio pus. Am J Trop Med Hyg 33: 953–960

    PubMed  CAS  Google Scholar 

  • Weaver SC, Scott TW, Lorenz LH, Lerdthusnee K, Romoser WS (1988) Togavirus-associated pathologic changes in a natural mosquito vector. J Virol 62: 2083–2090

    PubMed  CAS  Google Scholar 

  • Weaver SC, Scott TW, Lorenz LH (1990) Patterns of eastern equine encephalomyelitis virus infection in Culiseta melanura (Diptera: Culicidae). J Med Entomol 27: 878–891

    PubMed  CAS  Google Scholar 

  • Weaver SC, Scott TW, Lorenz LH, Repik PR (1991a) Detection of eastern equine encephalomyelitis virus deposition in Culiseta melanura following ingestion of radiolabeled virus in blood meals. Am J Trop Med Hyg 44: 250–259

    PubMed  CAS  Google Scholar 

  • Weaver SC, Scott TW, Rico-Hesse R (1991b) Molecular evolution of eastern equine encephalomyelitis virus in North America. Virology 182: 774–784

    Article  CAS  Google Scholar 

  • Wright S (1932) The roles of mutation, inbreeding, crossbreeding and selection in evolution. Proceedings of the Sixth International Congress of Genetics 1, pp 356–366

    Google Scholar 

  • Wright S (1982) Character change, speciation, and the higher taxa. Evolution 36: 427–443

    Article  Google Scholar 

  • Young NA, Johnson KM (1969) Antigenic variants of Venezuelan equine encephalitis virus: their geographic distribution and epidemiologic significance. Am J Epidemiol 89: 286–307

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biology, The University of California, San Diego, La Jolla, California, 92093, USA

    S. C. Weaver

  2. Department of Entomology and Center for Agricultural Biotechnology, The University of Maryland, College Park, Maryland, 20742, USA

    S. C. Weaver & T. W. Scott

  3. Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    R. Rico-Hesse

Authors
  1. S. C. Weaver
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  2. R. Rico-Hesse
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  3. T. W. Scott
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Editor information

Editors and Affiliations

  1. Department of Biology, C-016, University of California, 92093, San Diego, La Jolla, CA, USA

    John J. Holland Ph.D. (Professor of Biology and Molecular Genetics) (Professor of Biology and Molecular Genetics)

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© 1992 Springer-Verlag Berlin · Heidelberg

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Weaver, S.C., Rico-Hesse, R., Scott, T.W. (1992). Genetic Diversity and Slow Rates of Evolution in New World Alphaviruses. In: Holland, J.J. (eds) Genetic Diversity of RNA Viruses. Current Topics in Microbiology and Immunology, vol 176. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77011-1_7

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  • DOI: https://doi.org/10.1007/978-3-642-77011-1_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77013-5

  • Online ISBN: 978-3-642-77011-1

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