Skip to main content
SpringerLink
Log in

Endothelial Cell Growth Factor and Its Receptor

  • Conference paper
Molecular Biology of the Arterial Wall

  • 74 Accesses

Abstract

A new family of anionic polypeptide mitogens has been defined on the basis of biochemical and biological homologies (1,2,3,4). This polypeptide family structurally encompases endothelial cell growth factor (3), acidic-fibroblast growth factor (4), class I-heparin-binding growth factor and the hypothalamus- (5), brain- (6), eye- (7) and retina-derived (8) growth factors. These endothelial cell growth factor (ECGF) polypeptides stimulate endothelial cell DNA synthesis (9) and migration (10) in vitro and induce angiogenesis in vivo (). The proliferative and chemotactic activities of ECGF are potentiated by the glycosaminoglycan, heparin (11,12). This property is a unique attribute of the ECGF polypeptide family (1,2,11,12) and may involve the induction of a stable structural protein conformation by a non-covalent association between the glycosaminoglycan and the polypeptide (11).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Schreiber, A.B., Kenny, J., Kowalski, J., Thomas, K.A., Gimenez-Gallego, G., Rios-Candelore, M., D. Salvo, J., Baritault, d., Courty, J., Courtois, Y., Moenner, M., Loret, C., Burgess, W.H., Melhman, T., Friesel, R., Johnson, W. and Maciag, T., J. Cell Biol., 101, 1623–1626 (1985).

    Article  PubMed  CAS  Google Scholar 

  2. Lobb, R.R., Harper, J.W. and Fett, J.W., Annal. Biochem., 154, 1–14 (1986).

    Article  CAS  Google Scholar 

  3. Burgess, W.H., Mehlman, T., Marshak, D.R., Fraser, B.A. and Maciag, T., Proc. Natl. Acad. Sci., U.S.A., 83, 7216–7220 (1986).

    Article  CAS  Google Scholar 

  4. Gimenez-Gallego, G., Rodkey, J., Bennett, C., Rios-Canderlore, M., Di Salvo, J. and Thomas, K.A., Science, 230, 1385–1388 (1985).

    Article  PubMed  CAS  Google Scholar 

  5. Klagsbrun, M. and Shing, Y., Proc. Natl. Acad. Sci., U.S.A., 82, 805–809 (1985).

    Article  CAS  Google Scholar 

  6. Huang, J.S., Huang, s.s. and Kuo, M.-D., J. Biol. Chem., 261, 11600–11607 (1986).

    PubMed  CAS  Google Scholar 

  7. Courty, J., Loret, C., Moenner, M., Chevallier, B., Lagente, O., Courtois, Y. and Barritault, D., Biochemie, 67, 265–269 (1985).

    Article  CAS  Google Scholar 

  8. D’Amore, P.A. and Klagsbrum, M., J. Cell Biol., 99, 1545–1549 (1985).

    Article  Google Scholar 

  9. Maciag, T., Mehlman, T., Friesel, R. and Schreiber, A.B., Science, 225, 932–935 (1984).

    Article  PubMed  CAS  Google Scholar 

  10. Terranova, V.P., DiFlorio, T., Lyall, R., Hic, S., Friesel, R. and Maciag, T. J. Cell Biol., 101, 2330–2334 (1985).

    Article  PubMed  CAS  Google Scholar 

  11. Schreiber, A.B., Kenney, J., Kowalsky, W.J., Friesel, R., Mehlman, T. and Maciag, T., Proc. Natl. Acad. Sci., U.S.A., 82, 6138–6142 (1985).

    Article  PubMed  CAS  Google Scholar 

  12. Thornton,.S.C., Mueller, S.N. and Levine, E.M., Science, 222, 623–625 (1983).

    Article  Google Scholar 

  13. Jaye, M., Howk, R., Burgess, W.H., Ricca, G.A., Chiu, I.-M., Rayera, M., O’Brien, S.J., Modi, W.S., Maciag, T., and Drohan, W.N., Science, 233, 541–545 (1986).

    Article  PubMed  CAS  Google Scholar 

  14. Thomas, K.A. and Gimenez-Gallego, G., Trends in Biochem. Sci., 12, 8184 (1986).

    Google Scholar 

  15. Burgess, W.H., Mehlman, T., Friesel, R., Johnson, W.V. and Maciag, T., J. Biol. Chem., 260, 11389–11392 (1985).

    PubMed  CAS  Google Scholar 

  16. Abraham, J.A., Mergia, A., Whang, J.L., Tumolo, A., Friedman, J., Hjerrild, K.A., Gospodarowicz, D. and Fiddes, J.C., Science, 233, 545–548 (1986).

    Article  PubMed  CAS  Google Scholar 

  17. Auron, P.E., Webb, A.C., Rosenwasser, L.J., Mucci, S.F., Rich, A., Wolff, S.M. and Dinarello, C.A., Proc. Natl. Acad. Sci. U.S.A., 81, 7907–7911 (1984).

    Article  PubMed  CAS  Google Scholar 

  18. James, R. and Bradshaw, R.A., Ann. Rev. Biochem., 53, 259–292 (1984).

    Article  PubMed  CAS  Google Scholar 

  19. Friesel, R., Burgess, W.H., Mehlman, T. and Maciag, T., J. Biol. Chem., 261, 7581–7584 (1986).

    PubMed  CAS  Google Scholar 

  20. Huang, S.S. and Huang, J.S., J. Biol. Chem., 261, 9579–9582 (1986).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Cell Biology, Biotechnology Research Center, 4 Research Court, Rockville, Maryland, 20850, USA

    T. Maciag & W. H. Burgess

Authors
  1. T. Maciag
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. H. Burgess
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Heidelberger Akademie der Wissenschaften, Karlstrasse 4, 6900, Heidelberg, Germany

    Gotthard Schettler (Präsident) (Präsident)

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Maciag, T., Burgess, W.H. (1987). Endothelial Cell Growth Factor and Its Receptor. In: Schettler, G. (eds) Molecular Biology of the Arterial Wall. Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften, vol 1987/88 / 1987/4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83118-8_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83118-8_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17899-6

  • Online ISBN: 978-3-642-83118-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation