Abstract
In this chapter, we will review some aspects of work in our laboratory on the control of growth and differentiation in human teratocarcinoma stem cells. We begin by describing the three cell types which we have isolated in vitro from human teratomas: embryonal carcinoma, yolk sac carcinoma resembling visceral endoderm (solid yolk sac carcinoma), and yolk sac carcinoma resembling parietal endoderm (endodermal sinus tumour). Next, we discuss the development of a new panel of monoclonal antibodies for the study of cell differentiation lineage in human teratomas. We then describe properties of a spontaneously differentiating multipotent clone of human embryonal carcinoma, and we present evidence of possible paracrine growth interaction between teratocarcinoma stem cells and yolk sac carcinoma cells.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Andrews PW, Damjanov I (1985) Immunochemistry of human teratocarcinoma stem cells. In: Sell S, Reisfeld RA (eds) Monoclonal antibodies in cancer. Humana, Clifton, pp 339–364
Andrews PW, Bronson DL, Benham F, Strickland S, Knowles BB (1980) A comparative study of eight cell lines derived from human testicular teratocarcinoma. Int J Cancer 26: 269–280
Andrews PW, Goodfellow P, Damjanov I (1983) Human teratocarcinoma cells in culture. Cancer Sury 2: 41–73
Andrews PW, Damjanov I, Simon D, Banting GS, Carlin C, Dracopoli NC, Fogh J (1984) Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Lab Invest 50: 147–162
Boyer B, Tucker GC, Valles AM, Franke WW, Thierry JP (1989) Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells. J Cell Biol 109: 1495–1509
Cooper S, Pera MF (1988) Vitronectin production by human yolk sac carcinoma cells resembling parietal endoderm. Development 104: 565–574
Hogan BLM, Barlow DP, Tilly R (1983) F9 teratocarcinoma cells as a model for the differentiation of parietal and visceral endoderm in the mouse embryo. Cancer Sury 2: 115–140
Pera MF, Blasco-Lafita MJ, Mills J (1987) Cultured stem cells from human testicular teratomas: the nature of human embryonal carcinoma, and its composition with two types of yolk sac carcinoma. Int J Cancer 40: 334–343
Pera MF, Blasco-Lafita MJ, Cooper S, Mason M, Mills J, Monaghan P (1988) Analysis of cell differentiation lineage in human teratomas using new monoclonal antibodies to cytostructural antigens of embryonal carcinoma cells. Differentiation 39: 139–149
Pera MF, Cooper S, Mills J, Parrington JM (1989) Isolation and characterization of a multipotent clone of human embryonal carcinoma cells. Differentiation 42: 10–23
Smith AG, Heath JK, Donaldson DD, Wong GG, Moreau J, Stahl M, Rogers D (1988) Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 336: 688–690
Thompson S, Stern PL, Webb M, Walsh FS, Engstrom W, Evans EP, Shi WK, Hopkins B, Graham CF (1984) Cloned human teratoma cells differentiate into neuron-like cells and other cell types in retinoic acid. J Cell Sci 72: 37–64
Williams RL, Hilton DJ, Pease S, Wilson TA, Stewart CL, Gearing DP, Wagner EF, Metcalf D, Nicola NA, Gough NM (1988) Myeloid leukemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336: 684–687
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Pera, M.F., Cooper, S., Bennet, W., Crawford-Bryce, I. (1991). Human Embryonal Carcinoma and Yolk Sac Carcinoma in Vitro: Cell Lineage Relationships and Possible Paracrine Growth Regulatory Interactions. In: Oosterhuis, J.W., Walt, H., Damjanov, I. (eds) Pathobiology of Human Germ Cell Neoplasia. Recent Results in Cancer Research, vol 123. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84485-0_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-84485-0_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-84487-4
Online ISBN: 978-3-642-84485-0
eBook Packages: Springer Book Archive