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Cytotoxic T Cell Effector and Memory Function in Viral Immunity

  • Chapter
Transgenic Models of Human Viral and Immunological Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 206))

Abstract

The first evidence that virus-specific CD8+ cytotoxic T lymphocytes (CTLs) are primary effectors in vivo came shortly after the discovery of major histo- compatibility complex (MHC)-restricted CD8+ CTL activity (Zinkernagel and Doherty 1974). Adoptive transfer of immune spleen cells from mice of MHC type A into A or (AxB) F1, but not B, virus-infected recipients caused massive inflammatory pathology (Doherty and Zinkernagel 1975; DOHERTY et al. 1976b) and acute elimination of the pathogen (BLANDEN et al. 1975a; Zinkernagel and Welsh 1976). This was repeated for situations in which A and B represented different MHC haplotypes or distinct allelic forms of class I MHC glycoproteins (Doherty and Zinkernagel 1975; Blanden et al. 1975b; Doherty et al. 1976a). The analysis was extended to H-2 mutant mice and, again, the spectrum of cross-reactivity for T cell effector function in vivo and CTL activity in vitro seemed to run in parallel (Doherty et al. 1976a; Zinkernagel and Doherty 1979).

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  1. Department of Immunology, St. Jude Children’s Research Hospital, 332 North Lauderdale, Memphis, TN, 38105, USA

    P. C. Doherty

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  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Francis V. Chisari M.D. (Member, Head) (Member, Head)

  2. Division of Experimental Pathology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Francis V. Chisari M.D. (Member, Head) (Member, Head)

  3. Department of Neuropharmacology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone M.D. (Member, Head) (Member, Head)

  4. Division of Virology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone M.D. (Member, Head) (Member, Head)

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Doherty, P.C. (1996). Cytotoxic T Cell Effector and Memory Function in Viral Immunity. In: Chisari, F.V., Oldstone, M.B.A. (eds) Transgenic Models of Human Viral and Immunological Disease. Current Topics in Microbiology and Immunology, vol 206. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85208-4_1

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  • DOI: https://doi.org/10.1007/978-3-642-85208-4_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85210-7

  • Online ISBN: 978-3-642-85208-4

  • eBook Packages: Springer Book Archive

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