Abstract
From an evolutionary point of view, macrophages form an ancient cell population, representing the main host defense mechanism until the development of the immune system. It might be speculated that, during evolution, macrophages have also acquired important functions in the regulation of humoral and cellular immune reactions and in the control of cell functions of various non-phagocytic cells. As a consequence, in mammals, macrophages may be multifunctional cells.
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References
Austyn JM (1992) Antigen uptake and presentation by dendritic leukocytes. Semin Immunol 4:227–236
Austyn JM (1993) Dendritic cells: Nature’s adjuvants. NATO ASI series. Series A. Life sciences Vol. 261, pp1–10, Plenum Press
Badell E, Pasquetto V, Van Rooijen N, Druilhe P (1995) A mouse model for human malaria parasites. Parasitology Today In press
Biewenga J, Van der Ende MB, Krist LFG, Borst A, Ghufron M, Van Rooijen N (1995) Macrophage depletion and repopulation in the rat after i.p. administration of Cl2MBP-liposomes: Depletion kinetics and accelerated repopulation of peritoneal and omental macrophages by administration of Freund’s adjuvant. Cell Tissue Res 280:189–196
Bogers WMJM, Stad RK, Janssen DJ, Prins FA, van Rooijen N, van Es LA, Daha MR (1991a) Kupffer cell depletion in vivo results in clearance of large sized IgA aggregates in rats by liver endothelial cells. Clin Exp Immunol 85:128–136
Bogers WMJM, Stad RK, Janssen DJ, van Rooijen N, van Es LA, Daha MR (1991b) Kupffer cell depletion “in vivo” results in preferential elimination of IgG aggregates and immune complexes via specific Fc receptors on rat liver endothelial cells. Clin Exp Immunol 86:328–333
Buiting, AMJ (1995) Splenic macrophage subpopulations: Origin, Turnover and Functional Aspects. Academic Thesis, Vrije Universiteit, Amsterdam
Ciaassen E (1987) Antibody Forming Cells in the Spleen. Academic Thesis, Vrije Universiteit, Amsterdam
Dal Monte P and Szoka Jr FC (1989) Effect of liposome encapsulation on antigen presentation in vitro; comparison of presentation by peritoneal macrophages and B cell tumors. J Immunol 142:1437–1443
Dai R, van Rooijen N, Dijkstra CD, Streilein JW (1995) Relative roles of T cells and macrophages in cytokine-mediated functional transformation of cultured splenic dendritic cells. Cell Immunol In press
Debrick JE, Campbell PA, Staerz UD (1991) Macrophages as accessory cells for class-I MHC restricted immune responses. J Immunol 147:2846–2852
Delemarre FGA (1990) The Role of Macrophages in the Humoral Immune Response in Lymph Nodes and Spleen of Mice. Academic Thesis, Vrije Universiteit, Amsterdam
Delemarre FGA, Kors N, van Rooijen N (1991) Elimination of spleen and of lymph node macrophages and its difference in the effect on the immune response to participate antigens. Immunobiology 182:70–78
Fadok VA, Savill JS, Haslett C, Bratton DL, Doherty DE, Campbell PA, Henson PM (1992) Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J Immunol 149:4029–4035
Fraser CC, Chen BP, Webb S, van Rooijen N, Kraal G (1995) Circulation of human hemopoietic cells in SCID mice following Cl2MDP-liposome mediated macrophage depletion. Blood In press
Heuff G, Oldenburg HSA, Boutkan H, Visser JJ, Beelen RHJ, Van Rooijen N, Dijkstra CD, Meyer S (1993) Enhanced tumour growth in the rat liver after selective elimination of Kupffer cells. Canc Immun Immunother 37:125–130
Holt PG, Oliver J, Bilyk N, McMenamin C, McMenamin PG, Kraal G, Thepen T, (1993) Downregulation of the antigen presenting cell functions of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med 177:397–407.
Huang L, Reddy R, Nair SK, Zhou F, Rouse BT (1992) Liposomal delivery of soluble protein antigens for Class I MHC mediated antigen presentation. Res Immunol 143:192–196.
Nair S, Buiting AMJ, van Rooijen N, Huang L, Rouse BT (1995) Interaction between macrophages and dendritic cells for induction of cytotoxic T lymphocyte responses. Int Immunol In press
Qian Q, Jutila MA, van Rooijen N, Cutler JE, (1994) Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental dissemineted candidiasis. J Immunol 152:5000–5008
Soesatyo M, Biewenga J, van Rooijen N, Kors N, Sminia T (1991) The “in situ” immune response of the rat after intraperitoneal depletion of macrophages by liposome-encapsulated dichloromethylene diphosphonate. Res Immunol 142:533–540
Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271
Su D, van Rooijen N (1989) The role of macrophages in the immunoadjuvant action of liposomes: Effects of elimination of splenic macrophages on the immune response against intravenously injected liposome associated albumin antigen. Immunology 66:466–470
Szoka FC Jr (1991) The macrophage as the principal antigen presenting cell for liposome encapsulated antigens. Res Immunol 142:186–188
Thepen T, van Rooijen N, Kraal G (1989) Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune responses in mice. J Exp Med 170:499–509
Vanderkerken K, Bouwens L, van Rooijen N, Van den Berg K, Baekeland M, Wisse E (1995) The role of Kupffer cells in the differentiation process of hepatic NK cells. Hepatology In press
van Oss CJ, Gillman CF, Neumann AW (1974) Phagocytosis as a surface phenomenon. IV. The minimum size and composition of antigen-antibody complexes that can become phagocytized. Immunol Commun 3:77–84
van Rooijen N, van Nieuwmegen R (1984) Elimination of phagocytic cells in the spleen after intravenous injection of liposome encapsulated dichloromethylene-diphosphonate. An enzymehistochemical study. Cell Tissue Res 238:355–358
van Rooijen N (1992) Macrophages as accessory cells in the “in vivo” humoral immune response: From processing of particulate antigens to regulation by suppression. Sem Immunol 4:237–245
van Rooijen N, Sanders A (1994) Liposome mediated depletion of macrophages: Mechanism of action, preparation of liposomes and applications. J Immunol Meth 174:83–93
Zhou F, Rouse BT, Huang L (1992) Induction of cytotoxic T lymphocytes with protein antigen entrapped in membranous vehicles. J Immunol 149:1599–1604
Wijburg OLC, Heemskerk MHM, Sanders A, Boog CJP, van Rooijen N (1995) Role of CD4+ cytotoxic T lymphocytes in recovery from mouse hepatitis virus infection, submitted
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© 1996 Springer-Verlag Berlin Heidelberg
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van Rooijen, N., Wijburg, O.L.C., van den Dobbelsteen, G.P.J.M., Sanders, A. (1996). Macrophages in Host Defense Mechanisms. In: Potter, M., Rose, N.R. (eds) Immunology of Silicones. Current Topics in Microbiology and Immunology, vol 210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85226-8_16
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DOI: https://doi.org/10.1007/978-3-642-85226-8_16
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