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Drugs which block the storage of 5-hydroxytryptamine and related amines

  • Chapter
5-Hydroxytryptamine and Related Indolealkylamines

Abstract

In 1955 Shore, Brodie and coworkers (Shore, Silver and Brodie 1955, Pletscher, Shore and Brodie 1955) discovered that reserpine caused a marked decrease in the concentration of 5-hydroxytryptamine (5-HT) in tissues and a concomitant rise in the urinary excretion of the 5-HT metabolite 5-hydroxyindoleacetic acid. The deep physiological significance of this discovery became even more evident when reserpine soon afterwards was found to affect tissue catecholamines in a similar manner, an effect leading to block of adrenergic transmission mechanisms (Carlsson and Hillarp 1956a, Bertler, Carlsson and Rosengren 1956). Since then numerous papers have appeared, in which the effects of Rauwolfia alkaloids and a group of similarly acting benzoquinolizines (Pletscher, Besendorf and Bächtold 1958) have been further analyzed. Particular interest has been focussed on the mechanism of action on the abovementioned amines and on the relationship between this action and the various pharmacological effects of Rauwolfia alkaloids and benzoquinolizines. It is the aim of the present Chapter to review and discuss the pertinent literature dealing with these fundamental problems rather than to review in detail the enormous literature on the pharmacology of these agents.

The work done in the reviewer’s laboratory which is described in this chapter was supported largely by research grants from the United States Air Force, monitored by the European Office, Office of Aerospace Research (Grant No. AF-EOAR 63-14), and from the Swedish State Medical Research Council.

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References

  • Abboud, F. M., and J. W. Eckstein: Effects of small oral doses of reserpine on vascular responses to tyramine and norepinephrine in man. Circulation 29, 219–223 (1964).

    PubMed  CAS  Google Scholar 

  • Abood, L. G., and K. L. Romanchek: The chemical constitution and biochemical effects of psychotherapeutic and structurally related agents. Ann. N.Y. Acad. Sci. 66, 812–825 (1957).

    PubMed  CAS  Google Scholar 

  • Ahlbaum, H. G., and L. J. Milch: The effect of central nervous system drugs on the incorporation of radioactive carbon into brain adenosine triphosphate (ATP). Ann. N.Y. Acad. Sci. 96, 190–198 (1962).

    Google Scholar 

  • Andén, N.-E., A. Carlsson, A. Dahlström, K. Fuxe, N.-Å. Hillarp, and K. Larsson: Demonstration and mapping out of nigro-neostriatal dopamine neurons. Life Sci. 3, 523–530 (1964a).

    PubMed  Google Scholar 

  • Andén, N.-E., A. Carlsson, and N.-Å. Hillarp: Inhibition by 5-hydroxytryptophan of insulininduced adrenaline depletion. Acta pharmacol. (Kbh.) 21, 183–186 (1964).

    Google Scholar 

  • Andén, N.-E., A. Carlsson, and N.-Å. Hillarp., and T. Magnusson: 5-Hydroxytryptamine release by nerve stimulation of the spinal cord. Life Sci. 3, 473–478 (1964b).

    PubMed  Google Scholar 

  • Andén, N.-E., A. Carlsson, and B. Waldeck: Reserpine-resistent uptake mechanisms of noradrenaline in tissues. Life Sci. 2, 889–894 (1963).

    Google Scholar 

  • Andén, N.-E., and T. Magnusson: Functional effect of noradrenaline depletion by a-methyl meta-tyrosine, metaraminol and d-adrenaline. Paper read at Second Internat. Pharmacological Meeting, August 20–23, 1963, Prague, Czeckoslovakia.

    Google Scholar 

  • Andén, N.-E., and T. Magnusson. and B. Waldeck: Correlation between noradrenaline uptake and adrenergic nerve function after reserpine treatment. Life Sci. 3, 19–25 (1964).

    PubMed  Google Scholar 

  • Andén, N.-E., B.-E. Roos, and B. Werdinius: 3,4-Dihydroxyphenylacetic acid in rabbit corpus striatum normally and after reserpine treatment. Life Sci. 2, 319–325 (1963).

    Google Scholar 

  • Andén, N.-E., B.-E. Roos, and B. Werdinius: Effects of chlorpromazine, haloperidol and reserpine on the levels of phenolic acids in rabbit corpus striatum. Life Sci. 3, 149–158 (1964).

    Google Scholar 

  • Ashcroft, G. W., and D. F. Sharman: Drug-induced changes in the concentration of 5-OR indolyl compounds in cerebrospinal fluid and caudate nucleus. Brit. J. Pharmacol. 19, 153–160 (1962).

    PubMed  CAS  Google Scholar 

  • Axelrod, J., G. Hertting, and R. W. Patrick: Inhibition of H3-norepinephrine release by monoamine oxidase inhibitors. J. Pharmacol. exp. Ther. 134, 325–328 (1961).

    PubMed  CAS  Google Scholar 

  • Balzer, H., P. Holtz u. D. Palm: Reserpin und γ-Aminobuttersäuregehalt des Gehirns. Experientia (Basel) 17, 38–40 (1961a).

    CAS  Google Scholar 

  • Balzer, H., P. Holtz u. D. Palm: Reserpin und Glykogengehalt der Organe. Experientia (Basel) 17, 304–305 (1961b).

    CAS  Google Scholar 

  • Balzer, H., u. D. Palm: Über den Mechanismus der Wirkung des Reserpins auf den Glykogengehalt der Organe. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 243, 65–84 (1962).

    CAS  Google Scholar 

  • Barbeau, A., T. L. Sourkes et G. F. Murphy: Les catécholamines dans la maladie de Parkinson. In: J. De Ajuriaguerra, Ed., Monoamines et système nerveux central. Symposium Bel-Air, Geneva 1961, p. 247–262. Geneva: Georg & Co. 1962.

    Google Scholar 

  • Barrett, W. E., A. J. Plummer, A. E. Earl, and B. Rogie: Effect of reserpine on gastric secretion of the dog. J. Pharmacol. exp. Ther. 113, 3 (1955).

    Google Scholar 

  • Barrett, W. E., A. J. Plummer, R. A. Rutledge, and R.Weiss: A pharmacological investigation of an ether of methyl epireserpate. J. Pharmacol. exp. Ther. 138, 78–81 (1962).

    PubMed  CAS  Google Scholar 

  • Barrett, W. E., R. Rutledge, and A. J. Plummer: Pharmacology of SU-2064, an ether of methyl epireserpate. Fed. Proc. 20 (Part 1), 393 (1961).

    Google Scholar 

  • Bartlet, A. L.: The 5-hydroxytryptamine content of mouse brain and whole mice after treatment with some drugs affecting the central nervous system. Brit. J. Pharmacol. 15, 140–146 (1960).

    PubMed  CAS  Google Scholar 

  • Beck, L., L. Y. Falcon, and E. F. Domino: Hemodynamic responses to reserpine inunanesthetized dogs immobilized with neuromuscular blocking agents. J. Pharmacol. exp. Ther. 119, 133 (1957).

    Google Scholar 

  • Bein, H. J.: Zur Pharmakologie des Reserpin, eines neuen Alkaloids, aus Rauwolfia Serpentina BENTH. Experientia (Basel) 9, 107–110 (1953).

    CAS  Google Scholar 

  • Bein, H. J.: Significance of selected central mechanisms for the analysis of the action of reserpine. Ann. N.Y. Acad. Sci. 61, Art. 1, 4–16 (1955).

    PubMed  CAS  Google Scholar 

  • Bein, H. J.: The pharmacology of Rauwolfia. Pharmacol. Rev. 8, 435–483 (1956).

    PubMed  CAS  Google Scholar 

  • Bein, H. J.: Effects of reserpine on the functional strata of the nervous system. In: S. Garattini and V. Ghetti, Eds., Psychotropic Drugs, p. 325–331. Amsterdam: Elsevier Publ. Co. 1957.

    Google Scholar 

  • Belford, J., and M. R. Feinleib: Phosphorylase activity in heart and brain after reserpine, iproniazid and other drugs affecting the central nervous system. Biochem. Pharmacol. 6, 189–194 (1961).

    CAS  Google Scholar 

  • Benditt, E. P., and R.L. Wong: Concentration of 5-hydroxytryptamine in mammalian enterochromaffin cells and its release by reserpine. J. exp. Med. 105, 509–520 (1957).

    PubMed  CAS  Google Scholar 

  • Benson, G. K.: Effect of reserpine on mammary gland involution, and on other organs in the rat. Proc. Soc. exp. Biol. (N.Y.) 99, 550–553 (1958).

    CAS  Google Scholar 

  • Benson, G. K.: Effects of tranquilizing drugs on mammary involution in the rat. Proc. Soc. exp. Biol. (N.Y.) 103, 132–137 (1960).

    CAS  Google Scholar 

  • Bertaccini, G. (1960): Quoted from ERSPAMER 1961.

    Google Scholar 

  • Bertler, Å.: Effect of reserpine on the storage of catecholamines in brain and other tissues. Acta physiol. scand. 51, 75–83 (1961).

    CAS  Google Scholar 

  • Bertler, Å., A. Carlsson, M. Lindqvist, and T. Magnusson: On the catechol amine levels in blood plasma after stimulation of the sympatho-adrenal system. Experientia (Basel) 14, 184 (1958).

    CAS  Google Scholar 

  • Bertler, Å., and E. Rosengren: Release by reserpine of catecholamines from rabbits ’hearts. Naturwissenschaften 22, 521 (1956).

    Google Scholar 

  • Bertler, Å., B. Falck, and CHR. Owman: Cellular localization of 5-hydroxytryptamine in the rat pineal gland. Kgl. Fysiogr. Sällsk. Lund Förh. 33, No 2, 13–16 (1963).

    Google Scholar 

  • Bertler, Å., N.-Å. Hillarp, and E. Rosengren: Storage of new-formed catecholamines in the adrenal medulla. Experientia (Basel) 16, 419 (1960a).

    CAS  Google Scholar 

  • Bertler, Å., N.-Å. Hillarp, and E. Rosengren: “Bound” and “free” catecholamines in the brain. Acta physiol. scand. 50, 113–118 (1960b).

    CAS  Google Scholar 

  • Bertler, Å., N.-Å. Hillarp, and E. Rosengren: Effect of reserpine on the storage of new-formed catecholamines in the adrenal medulla. Acta physiol. scand. 52, 44–48 (1961).

    CAS  Google Scholar 

  • Besendorf, H., u. A. Pletscher: Beeinflussung zentraler Wirkungen von Reserpin und 5-Hydroxytryptamin durch Isonicotinsäurehydrazide. Helv. physiol. pharmacol. Acta 14, 383–390 (1956).

    PubMed  CAS  Google Scholar 

  • Bhargava, K.P., and H. L. Borison: Effects of Rauwolfia alkaloids on hypothalamic, medullary and spinal vasoregulatory systems. J. Pharmacol. exp. Ther. 115, 464–479 (1955).

    PubMed  CAS  Google Scholar 

  • Bhattacharya, B. K., and G. P. Lewis: The effects of reserpine and compound 48/80 or the release of amines from the mast cells of rats. Brit. J. Pharmacol. 11, 411–416 (1956).

    PubMed  CAS  Google Scholar 

  • Bickel, M. H., A. Carpi, and D. Bovet: Action of reserpine and monoamine oxidase inhibitors on the urinary excretion of catecholamines in the rat. Helv. physiol. pharmacol. Acta 19, 279–284 (1961).

    PubMed  CAS  Google Scholar 

  • Birkmayer, W., u. O. Hornykiewicz: Der L-Dioxyphenylalanin (= L-DOPA)-Effekt beim Parkinson-Syndrom des Menschen: Zur Pathogenese und Behandlung der Parkinson-Akinese. Arch. Psychiat. Nervenkr. 203, 560–574 (1962).

    PubMed  CAS  Google Scholar 

  • Blaschko, H., and T. L. Chrusciel: The decarboxylation of amino acids related to tyrosine and their awakening action in mice. J. Physiol. (Lond.) 151, 272–284 (1960).

    CAS  Google Scholar 

  • Bogdanski, D. F., F. Sulser, and B. B. Brodie: Comparative action of reserpine, tetrabenazine and chlorpromazine on central parasympathetic activity: effects on pupillary size and lacrimation in rabbit and salivation in dogs. J. Pharmacol. exp. Ther. 132, 176–182 (1961).

    CAS  Google Scholar 

  • Born, G. V. R., G. I. C. Ingram, and R. S. Stacey: The relationship between 5-hydroxy-tryptamine and adenosine triphosphate in blood platelets. Brit. J. Pharmacol. 13, 62–64 (1958).

    PubMed  CAS  Google Scholar 

  • Brodie, B. B., and F. Bogdanski: Drug action and brain monoamines in lower vertebrates. Internat, symposium on problems of the brain. Held in Galesburg, Illinois, March 1 to 3, 1963; to be published in Progress in Brain Research.

    Google Scholar 

  • Brodie, B. B., and E. Costa: Some current views on brain monoamines. In: J. De Ajuriaguerra, Ed., Monoamines et système nerveux central. Symposium Bel-Air, Geneva 1961, p. 13–49. Geneva: Georg & Co. 1962.

    Google Scholar 

  • Brodie, B. B., K. F. Finger, F. B. Orlans, G. P. Quinn, and F. Sulser: Evidence that tranquilizing action of reserpine is associated with change in brain serotonin and not in brain norepinephrine. J. Pharmacol. exp. Ther. 129, 250–256 (1960).

    PubMed  CAS  Google Scholar 

  • Brodie, B. B., J. S. Olin, R. Kuntzman, and P.A. Shore: Possible interrelationship between release of brain norepinephrine and serotonin by reserpine. Science 125, 1293–1294 (1957a).

    PubMed  CAS  Google Scholar 

  • Brodie, B.B., A. Pletscher, and P. A. Shore: Possible role of serotonin in brain function. J. Pharmacol. exp. Ther. 116, 9 (1956).

    Google Scholar 

  • Brodie, B.B., S. Spector, and P. A. Shore: Interaction of drugs with norepinephrine in the brain. Pharmacol. Rev. 11, 548–564 (1959).

    PubMed  CAS  Google Scholar 

  • Brodie, B.B., E. G. Tomich, R. Kuntzman, and P. A. Shore: On the mechanism of action of reserpine: effect of reserpine on capacity of tissues to bind serotonin. J. Pharmacol. exp. Ther. 119, 461–467 (1957b).

    PubMed  CAS  Google Scholar 

  • Brune, G., G. R. Pscheidt, and H. E. Himwich: Different responses of urinary tryptamine and of total catecholamines during treatment with reserpine and isocarboxazid in schizophrenic patients. Intern. J. Neuropharmacol. 2, 17–24 (1963).

    CAS  Google Scholar 

  • Bülbring, E., and A. Crema: The action of 5-hydroxytryptamine, 5-hydroxytryptophan and reserpine on intestinal peristalsis in anaesthetized guinea-pigs. J. Physiol. (Lond.) 146, 29–53 (1959).

    Google Scholar 

  • Burack, W. R., N. Weiner, and P. B. Hagen: The effect of reserpine on the catecholamine and adenine nucleotide contents of adrenal gland. J. Pharmacol. exp. Ther. 130, 245–250 (1960).

    PubMed  CAS  Google Scholar 

  • Burn, J. H., and M. J. Rand: Reserpine and noradrenaline in artery walls. Lancet 1957 II, 1097.

    Google Scholar 

  • Burn, J. H., and M. J. Rand: The action of sympathomimetic amines in animals treated with reserpine. J. Physiol. (Lond.) 144, 314–336 (1958).

    CAS  Google Scholar 

  • Burn, J. H., and M. J. Rand: The effect of precursors of noradrenaline on the response to tyramine and sympathetic stimulation. Brit. J. Pharmacol. 15, 47–55 (1960).

    PubMed  CAS  Google Scholar 

  • Burn, J. H., and M. J. Rand: A new interpretation of the adrenergic nerve fiber. In: S. Garattini and P. A. Shore, Eds. Advanc. Pharmacol. 1, 2–30 (1962).

    Google Scholar 

  • Burton, R. M., N. O. Kaplan, A. Goldin, M. Leitenberg, S. R. Humphreys, and M. A. Sodd: Effect of reserpine and promazine on diphosphopyridine nucleotide synthesis in liver. Science 127, 30–32 (1958).

    PubMed  CAS  Google Scholar 

  • Buzas, A., et G. Régnier: Aminoalcoyl-1 réserpines. C. R. Acad. Sci. (Paris) 250, 1340–1342 (1960).

    CAS  Google Scholar 

  • Cahn, J., et M. Herold: Étude pharmacologique du Ro 1-9569 (Tétrabenazine). Psychiat. Neurol. (Basel) 140, 210–215 (1960).

    CAS  Google Scholar 

  • Callingham, B. A., and R. Cass: The effects of bretylium and cocaine on noradrenaline depletion. J. Pharm. Pharmacol. 14, 385–389 (1962).

    PubMed  CAS  Google Scholar 

  • Callingham, B. A., and M. Mann: Replacement of adrenaline and noradrenaline in the innervated and denervated adrenal gland, following depletion with reserpine. Nature (Lond.) 182, 1020–1021 (1958).

    CAS  Google Scholar 

  • Callingham, B. A., and M. Mann: Depletion and replacement of the adrenaline and noradrenaline contents of the rat adrenal gland, following treatment with reserpine. Brit. J. Pharmacol. 18, 138–149 (1962).

    PubMed  CAS  Google Scholar 

  • Carlsson, A.: Discussion remark in: J. R. Vane, G. E. W. Wolstenholme, and M. O’connor, Eds., Ciba Symposium on Adrenergic Mechanisms, p. 558. London: J. & A. Churchill 1960.

    Google Scholar 

  • Carlsson, A.: Functional significance of drug-induced changes in brain monoamine levels. Symposium on “Binding Sites of Brain Biogenic Amines”, held at Galesburg, Illinois, March 1963; Progress in Brain Research 8, 9–27 (1964a).

    Google Scholar 

  • Carlsson, A.: Evidence for a role of dopamine in extrapyramidal functions. Acta neuroveg. (Wien) 26, 484–493 (1964b).

    CAS  Google Scholar 

  • Carlsson, A., E. Boje Rasmussen, and P. Kristjansen: The urinary excretion of adrenaline and noradrenaline by schizophrenic patients during reserpine treatment. J. Neurochem. 4, 318–320 (1959).

    PubMed  CAS  Google Scholar 

  • Carlsson, A., H. Corrodi u. B. Waldeck: α-Substituierte Dopacetamide als Hemmer der Catechol-O-methyl-transferase und der enzymatischen Hydroxylierung aromatischer Aminosäuren. In den Catecholaminmetabolismus eingreifende Substanzen. 2. Mitt. Helv. chim. Acta 46, 2271–2285 (1963).

    CAS  Google Scholar 

  • Carlsson, A., B. Falck, K. Fuxe, and N.-Å. Hillarp: Cellular localization of monoamines in the spinal cord. Acta physiol. scand. 60, 112–119 (1964).

    PubMed  CAS  Google Scholar 

  • Carlsson, A., B. Falck, and N.-Å. Hillarp: Cellular localization of brain monoamines. Acta physiol. scand. 56(Suppl. 196), 1–27 (1962).

    CAS  Google Scholar 

  • Carlsson, A., and N.-Å. Hillarp: Release of adrenaline from the adrenal medulla of rabbits produced by reserpine. Kgl. Fysiogr. Sällsk. Lund Förh. 26, No 8 (1956a).

    Google Scholar 

  • Carlsson, A., and N.-Å. Hillarp: Release of adenosine triphosphate along with adrenaline and noradrenaline following stimulation of the adrenal medulla. Acta physiol. scand. 37, 235–239 (1956b).

    PubMed  CAS  Google Scholar 

  • Carlsson, A., and N.-Å. Hillarp: On the state of the catechol amines of the adrenal medullary granules. Acta physiol. scand. 44, 163–169 (1958).

    PubMed  CAS  Google Scholar 

  • Carlsson, A., and N,-Å, Hillarp: Formation of phenolic acids in brain after administration of 3,4-dihydroxyphenylalanine. Acta physiol. scand. 55, 95–100 (1962).

    PubMed  CAS  Google Scholar 

  • Carlsson, A., and N,-Å, Hillarp, and B. Hökfelt: The concomitant release of adenosine triphosphate and catechol amines from the adrenal medulla. J. biol. Chem. 227, 243–252 (1957).

    PubMed  CAS  Google Scholar 

  • Carlsson, A., and N,-Å, Hillarp, and B. Waldeck: A Mg++-ATP-dependent storage mechanism in the amine granules of the adrenal medulla. Med. exp. (Basel) 6, 47–53 (1962).

    CAS  Google Scholar 

  • Carlsson, A., and N,-Å, Hillarp, and B. Waldeck: Analysis of the Mg++-ATP dependent storage mechanism in the amine granules of the adrenal medulla. Acta physiol. scand. 59 (Suppl. 215), 1–38 (1963).

    Google Scholar 

  • Carlsson, A., J. Jonasson, and E. Rosengren: Time correlation between the effects of reserpine on behaviour and storage mechanism for arylalkylamines. Acta physiol. scand. 59, 474–477 (1963).

    PubMed  CAS  Google Scholar 

  • Carlsson, A., and M. Lindqvist: In-vivo decarboxylation of α-methyl DOPA and α-methyl metatyrosine. Acta physiol. scand. 54, 87–94 (1962).

    PubMed  CAS  Google Scholar 

  • Carlsson, A., and M. Lindqvist: Effect of chlorpromazine and haloperidol on the formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta pharmacol. (Kbh.) 20, 140–144 (1963).

    CAS  Google Scholar 

  • Carlsson, A., and M. Lindqvist, and T. Magnusson: 3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists. Nature (Lond.) 180, 1200 (1957).

    CAS  Google Scholar 

  • Carlsson, A., and M. Lindqvist, and T. Magnusson: On the biochemistry and possible functions of dopamine and noradrenaline in brain. In: J. R. Vane, G. E. W. Wolstenholme and M. O’connor, Eds. Ciba Symposium on Adrenergic Mechanisms, p. 434–439. London: J. & A. Churchill 1960.

    Google Scholar 

  • Carlsson, A., and M. Lindqvist, and T. Magnusson, and B. Waldeck: On the presence of 3-hydroxytyramine in brain. Science 127, 471 (1958).

    PubMed  CAS  Google Scholar 

  • Carlsson, A., E. Rosengren, Å. Bertler, and J. Nilsson: Effect of reserpine on the metabolism of catecholamines. In: S. Garattini and V. Ghetti, Eds., Psychotropic drugs, p. 363–372. Amsterdam: Elsevier Publ. Co. 1957.

    Google Scholar 

  • Carlsson, A., P. A. Shore, and B. B. Brodie: Release of serotonin from blood platelets by reserpine in vitro. J. Pharmacol exp. Ther. 120, 334–339 (1957).

    PubMed  CAS  Google Scholar 

  • Cass, R., P.B. Marshall, and J. F. Riley: S-Hydroxytryptamine and histamine in mast cells of the mouse and rat. J. Physiol. (Lond.) 141, 510–519 (1958).

    CAS  Google Scholar 

  • Castiau, J., et J. J. Reuse: Contribution à l’étude de la sécrétion gastrique postréserpinique. Arch. int. Pharmacodyn. 135, 489–491 (1962).

    PubMed  CAS  Google Scholar 

  • Chidsey, C. A., E. Braunwald, A. G. Morrow, and D. T. Mason: Myocardial norepinephrine concentration in man. Effects of reserpine and of congestive heart failure. New Engl. J. Med. 269, 653–658 (1963).

    PubMed  CAS  Google Scholar 

  • Child, J. J., P. Sutherland, and E. G. Tomich: Some effects of reserpine on barbitone anesthesia in mice. Biochem. Pharmacol. 6, 252–256 (1961).

    PubMed  CAS  Google Scholar 

  • Costa, E.: The neurochemical transducer concept-units in nervous system that synthesize, store and release monoamines in receptor sites. Symposium on “Binding Sites of Brain Biogenic Amines”, held at Galesburg, Illinois, March 1963; Progress in Brain Research 8, 168–185 (1964).

    Google Scholar 

  • Costa, E., G. L. Gessa, and B. B. Brodie: Influence of hypothermia on chlorpromazine induced changes in brain amine levels. Life Sci. No 7, 315–319 (1962).

    Google Scholar 

  • Costa, E., A. M. Revzin, R. Kuntzman, S. Spector, and B. B. Brodie: Role for ganglionic norepinephrine in sympathetic synaptic transmission. Science 133, 1822–1823 (1961).

    PubMed  CAS  Google Scholar 

  • Gotten, M. De V., and N. C. Moran: Cardiovascular pharmacology. Ann. Rev. Pharmacol. 1, 261–286 (1961).

    Google Scholar 

  • Crout, J. R., A. J. Muskus, and u. Trendelenburg: Effect of tyramine on isolated guineapig atria in relation to their noradrenaline stores. Brit. J. Pharmacol. 18, 600–611 (1962).

    PubMed  CAS  Google Scholar 

  • Cuenca, E., E. Costa, R. Kuntzman, and B. B. Brodie: The methyl ether of methyl reserpate; a prototype of reversible short-acting tranquilizing agents. Med. exp. (Basel) 5, 20–24 (1961).

    CAS  Google Scholar 

  • Dahl, E., B. Falck, M. Lindqvist, and C. v. Mecklenburg: Monoamines in mollusc neurons. Kgl. fysiogr. Sällsk. Lund Förh. 32, No 8, 89–91 (1962).

    CAS  Google Scholar 

  • Dahlström, A., and K. Fuxe: Existence of monoamine-containing neurons in the central nervous svstem. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta physiol. scand. 62, Suppl. 232, 1–55 (1964).

    Google Scholar 

  • Dahlström, A., and K. Fuxe, N.-Å. Hillarp, and T. Malmfors: Adrenergic mechanisms in the pupillary lightreflex path. Acta physiol. scand. 62, 119–124 (1964).

    Google Scholar 

  • Dasgupta, S. R., and T. J. Haley: Intraventricular administration of reserpine and its metabolites to conscious cats. Brit. J. Pharmacol. 12, 529–531 (1957).

    PubMed  CAS  Google Scholar 

  • Degkwitz, R., R. Frowein, C. Kulenkampff u. U. Mohs: Über die Wirkungen des L-dopa beim Menschen und deren Beeinflussung durch Reserpin, Chlorpromazin, Iproniazid und Vitamin B6. Klin, Wschr. 38, 120–123 (1960).

    CAS  Google Scholar 

  • Dengler, H. J., I. A. Michaelson, H. E. Spiegel, and E. O. Titus: The uptake of labeled norepinephrine by isolated brain and other tissues of the cat. Intern. J. Neuropharmacol. 1, 23–38 (1962).

    CAS  Google Scholar 

  • Dengler, H. J., H. E. Spiegel, and E. O. Titus: Uptake of tritium-labeled norepinephrine in brain and other tissues of cat in vitro. Science 133, 1072–1073 (1961a).

    PubMed  CAS  Google Scholar 

  • Dengler, H. J., H. E. Spiegel, and E. O. Titus: Effects of drugs on uptake of isotopic norepinephrine by cat tissues. Nature (Lond.) 191, 816–817 (1961b).

    CAS  Google Scholar 

  • De Ibaldi, A. P., and E. De Robertis: Action of reserpine on the submicroscopic morphology of the pineal gland. Experientia (Basel) 17, 122–124 (1961).

    Google Scholar 

  • Desclin, L.: Influence de la réserpine sur la glande mammaire du rat normal, du rat hypophysectomisé ou du rat hypophysectomisé porteur d’une greffe hypophysaire dans la capsule du rein. C. R. Soc. Biol. (Paris) 151, 1774–1776 (1958).

    Google Scholar 

  • Dews, P. B., and W. H. Morse: Behavioral pharmacology. Ann.Rev.Pharmacol. 1, 145–174 (1961).

    CAS  Google Scholar 

  • Dhar, M. M., J. D. Kohli, and S. K. Srivastava: Studies on the metabolism of reserpine. I. Identification of metabolites. J. Sci. Ind. Res. 14 C., 179–181 (1955).

    Google Scholar 

  • Domenjoz, R., u. W. Theobald: Zur Pharmakologie des Tofranil® (N-(3-Dimethylaminopropyl)-iminodibenzyl-hydrochlorid). Arch. int. Pharmacodyn. 120, 450–489 (1959).

    PubMed  CAS  Google Scholar 

  • Domino, E. F.: Human pharmacology of tranquilizing drugs. Clin. Pharmacol. Ther. 3, 599–664 (1962a).

    PubMed  CAS  Google Scholar 

  • Domino, E. F.: Sites of action of some central nervous system depressants. Ann. Rev. Pharmacol. 2, 215–250 (1962b).

    CAS  Google Scholar 

  • Domino, E. F., and R. H. Rech: Observations on the initial hypertensive response to reserpine. J. Pharmacol. exp. Ther. 121, 171–182 (1957).

    PubMed  CAS  Google Scholar 

  • Eechaute, W., E. Lacroix et I. Leusen: Effet inhibiteur de la tétrabénazine sur l’influence corticosurrénalienne de la réserpine. Experientia (Basel) 18, 233–234 (1962).

    CAS  Google Scholar 

  • Ehringer, H., O. Hornykiewicz u. K. Lechner: Die Wirkung des Chlorpromazins auf den Katecholamin-und 5-Hydroxytryptaminstoff Wechsel im Gehirn der Ratte. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 239, 507–519 (1960).

    CAS  Google Scholar 

  • Erspamer, V.: Observations on the 5-hydroxytryptamine (enteramine) release caused by reserpine in the rat. Experientia (Basel) 12, 63–64 (1956a).

    CAS  Google Scholar 

  • Erspamer, V.: Wirkung des Reserpins auf den 5-Hydroxytryptamin-(Enteramin)-Gehalt des Serums, der Milz des Darmtraktes und des Gehirns beim Huhn. Naturwissenschaften 43, 61–62 (1956b).

    CAS  Google Scholar 

  • Erspamer, V.: Release of 5-hydroxytryptamine by reserpine. Lancet 1956 I c, 511.

    Google Scholar 

  • Erspamer, V.: Recent research in the field of 5-hydroxytryptamine and related indolealkylamines. Fortschr. Arzneimittelforsch. 3, 151–367 (1961).

    PubMed  CAS  Google Scholar 

  • Erspamer, V., and C. Ciceri: Action of reserpine on the 5-hydroxytryptamine (enteramine) biosynthesis and metabolism in dogs and rats. Experientia (Basel) 13, 87–88 (1957).

    CAS  Google Scholar 

  • Euler, U. S. v., and F. Lishajko: Effect of reserpine on the release of noradrenaline from transmitter granules in adrenergic nerves. Science 132, 351–352 (1960).

    Google Scholar 

  • Euler, U. S. v., and F. Lishajko: Noradrenaline release from isolated nerve granules. Acta physiol. scand. 51, 193–203 (1961a).

    Google Scholar 

  • Euler, U. S. v., and F. Lishajko: Effect of reserpine on the release of catecholamines from isolated nerve and chromaffin cell granules. Acta physiol. scand. 52, 137–145 (1961b).

    CAS  Google Scholar 

  • Euler, U. S. v., and F. Lishajko: Effect of some drugs on noradrenaline release from nerve granules. Biochem. Pharmacol. 8, 62 (1961c).

    Google Scholar 

  • Euler, U. S. v., and F. Lishajko: Effect of some drugs on the release of noradrenaline from isolated nerve granules. Biochem. Pharmacol. 9, 77–84 (1962).

    Google Scholar 

  • Euler, U. S. v., and F. Lishajko: Effect of. adenine nucleotides on catecholamine release and uptake in isolated adrenergic nerve granules. Acta physiol. scand. (1963, in press).

    Google Scholar 

  • Everett, G. M., and J. E. P. Toman: Mode of action of Rauwolfia alkaloids and motor activity. Biol. Psychiat. 2, 75–81 (1959).

    Google Scholar 

  • Falck, B.: Observations on the possibilities of the cellular localization of monoamines by a fluorescence method. Acta physiol. scand. 56 (Suppl. 197), 1–25 (1962).

    Google Scholar 

  • Falck, B.: Cellular localization of monoamines. Symposium on “Binding Sites of Brain Biogenic Amines”, held at Galesburg, Illinois, March 1963; Progress in Brain Research 8, 28–44 (1964).

    Google Scholar 

  • Falck, B., and B. Hellmak: Evidence for the presence of biogenic amines in pancreatic islets. Experientia (Basel) 19, 139 (1963).

    CAS  Google Scholar 

  • Farrant, J.: Interactions between cocaine, tyramine and noradrenaline at the noradrenaline store. Brit. J. Pharmacol. 20, 540–549 (1963).

    PubMed  CAS  Google Scholar 

  • Fawaz, G.: Cardiovascular pharmacology. Ann. Rev. Pharmacol. 3, 57–90 (1963).

    Google Scholar 

  • Fiore-Donati, L., and E. Moltke: Effect of reserpine, 5-hydroxytryptamine and polymyxin B on mast cells and or tensile strength of healing wounds. Acta endocr. (Kbh.) 34, 430–436 (1960).

    CAS  Google Scholar 

  • Fischer, P., et J. Lecomte: Choc anaphylactique chez le lapin traité par réserpine. C. R. Soc. Biol. (Paris) 150, 1026–1028 (1956).

    CAS  Google Scholar 

  • Furchgott, R. F.: Discussion remark. In: J. R. Vane, G. E. W. Wolstenholme and M. O’connor, Eds., Ciba Symposium on Adrenergic Mechanisms, p. 584. London: J. & A. Churchill Ltd. 1960.

    Google Scholar 

  • Furchgott, R. F., and S. M. Kirpekar: Competition between ß-haloalkylamines and norepinephrine for sites in cardiac muscle. In: B. Uvnäs Ed., First International Pharmacological Meeting, vol. 7, Modern concepts in the relationship between structure and pharmacological activity, p. 339–350. Oxford: Pergamon Press 1963.

    Google Scholar 

  • Furness, P., and A. J. Plummer: Reversal of depressant activity of methyl 0-(2-tetrahydro-pyranyl) reserpate by monoamine oxidase inhibitors. Fed. Proc. 20 (Part 1), 394 (1961).

    Google Scholar 

  • Fuxe, K.: Cellular localization of monoamines in the median eminence and in the infundibular stem of some mammals. Acta physiol. scand. 58, 383–384 (1963).

    PubMed  CAS  Google Scholar 

  • Fuxe, K.: Cellular localization of monoamines in the median eminence and the infundibular stem of some mammals. Z. Zellforsch. 61, 710–724 (1964).

    PubMed  CAS  Google Scholar 

  • Fuxe, K., T. Hökfelt, and O. Nilsson: Observations on the cellular localization of dopamine in the caudate nucleus of the rat. Z. Zellforsch. 63, 701–706 (1964).

    PubMed  CAS  Google Scholar 

  • Gabe, M., H. Tuchmann-Duplessis et L. Mercier-Parot: Influence de la réserpine sur la neurosécrétion hypothalamo-hypophysaire du rat albinos. C. R. Acad. Sci. (Paris) 252, 1857–1859 (1961).

    CAS  Google Scholar 

  • Gaddum, J. H., W. A. Krivoy, and G. Laverty: The action of réserpine on the excretion of adrenaline and noradrenaline. J. Neurochem. 2, 249–253 (1958).

    PubMed  CAS  Google Scholar 

  • Gaffney, TH. E., CH. A. Chidsey, and E. Braunwald: Study of the relationship between the neurotransmitter store and adrenergic nerve block induced by réserpine and guanethidine. Circulat. Res. 12, 264–268 (1963).

    PubMed  CAS  Google Scholar 

  • Gal, E. M., P. A. Drewes, and C. A. Barraclough: Effect of réserpine and the metabolism of serotonin in tryptophan deficient rats. Biochem. Pharmacol. 8, 32 (1961).

    Google Scholar 

  • Galansino, G., R. Litta-Modignani, F. Berlinger, D. Billinger, and P. P. Foa: Studies on the release of serotonin and catecholamines in the pancreato-duodenal area. Proc. Soc. exp. Biol. (N.Y.) 112, 542–544 (1963).

    CAS  Google Scholar 

  • Garattini, S., A. Giachetti, A. Jori, L. Pieri, and L. Valzelli: Effect of imipramine, amitriptyline and their monomethyl derivatives on réserpine activity. J. Pharm. Pharmacol. 14, 509–514 (1962).

    PubMed  CAS  Google Scholar 

  • Garattini, S., R. Kato, and L. Valzelli: Effect of réserpine analogues on tissue serotonin. Experientia (Basel) 16, 120 (1960).

    CAS  Google Scholar 

  • Garattini, S., L. Lamesta, A. Mortari, and L. Valzelli: Pharmacological and biochemical effects of some réserpine derivatives. J. Pharm. Pharmacol. 13, 548–564 (1961).

    PubMed  CAS  Google Scholar 

  • Garattini, S., A. Mortari, A. Valsecchi, and L. Valzelli: Réserpine derivatives with specific hypotensive or sedative activity. Nature (Lond.) 183, 1273–1274 (1959).

    CAS  Google Scholar 

  • Garattini, S., and L. Valzelli: Researches on the mechanism of réserpine sedative action. Science 128, 1278–1279 (1958).

    PubMed  CAS  Google Scholar 

  • Garattini, S., L. Lamesta, Biochemistry and pharmacology of serotonin in the central nervous system. In: J. De Ajuriaguerra, Ed., Monoamines et système nerveux central, p. 59–88. Genève: George & Co. 1962.

    Google Scholar 

  • Gaunt, R., J. J. Chart, and A. A. Renzi: Endocrine Pharmacology. Science 133, 613–621 (1961).

    PubMed  CAS  Google Scholar 

  • Gaunt, R., J. J. Chart, and A. A. Renzi: Interactions of drugs with endocrines. Ann. Rev. Pharmacol. 3, 109–128 (1963).

    Google Scholar 

  • Gaunt, R., A. A. Renzi, N. Antonchak, G. J. Miller, and M. Gilman: Endocrine aspects of the pharmacology of réserpine. Ann. N.Y. Acad. Sci. 59, 22–35 (1954).

    PubMed  CAS  Google Scholar 

  • Gaunt, R., A. A. Renzi, and J.J.Chart: Endocrine pharmacology of methyl reserpate derivatives. Endocrinology 71, 527–535 (1962).

    PubMed  CAS  Google Scholar 

  • Gessa, G. L., E. Costa, R. Kuntzman, and B. B. Brodle: Evidence that the loss of brain catecholamine stores due to blockade of storage does not cause sedation. Life Sci. No 11, 605–616 (1962).

    Google Scholar 

  • Giarman, N. J.: Drug-induced changes in sub-cellular distribution of serotonin in brain. Symposium on Binding Sites of Brain Biogenic Amines, held at Galesburg, Illinois, March 1963; to be published in Progress in Brain Research.

    Google Scholar 

  • Giarman, N. J., and S. M. Schanberg: The intracellular distribution of 5-hydroxytryptamine (HT; serotonin) in the rat’s brain. Biochem. Pharmacol. 1, 301–306 (1958).

    Google Scholar 

  • Giarman, N. J., and S. M. Schanberg: Drug-induced alterations in the intracellular distribution of 5-hydroxytryptamine in rat’s brain. Biochem. Pharmacol. 8, 6 (1961).

    Google Scholar 

  • Giarman, N. J., and S. M. Schanberg: Drug-induced alterations of the subcellular distribution of 5-hydroxytryptamine (serotonin) in rat’s brain. Biochem. Pharmacol. 9, 93–96 (1962).

    PubMed  CAS  Google Scholar 

  • Gilgen, A., R. P. Maickel, O. Nikodijevic, and B. B. Brodle: Essential role of catecholamines in the mobilization of free fatty acids and glucose after exposure to cold. Life Sci. No 12, 709–715 (1962).

    Google Scholar 

  • Glazko, A. J., W. A. Dill, L. M. Wolf, and A. Kazenko: Studies on the metabolism of reserpine. J. Pharmacol. exp. Ther. 118, 377–387 (1956).

    PubMed  CAS  Google Scholar 

  • Görög, P., and L. Szporny: Effect of vincamin on the noradrenaline content of rat tissue. Biochem. Pharmacol. 8, 259–262 (1961).

    PubMed  Google Scholar 

  • Gray, W. D., CH. E. Ratjh, and R. W. Shanahan: The mechanism of the antagonistic action of reserpine on the anticonvulsant effect of inhibitors of carbonic anhydrase. J. Pharmacol, exp. Ther. 139, 350–360 (1963).

    CAS  Google Scholar 

  • Green, A. F.: Antihypertensive drugs. In: S. Garattini and P.A. Shore, Eds. Advanc. Pharmac. 1, 162–228 (1962).

    Google Scholar 

  • Green, H., and J. Sawyer: Intracellular distribution of norepinephrine in rat brain. I. Effect of reserpine and the monoamine oxidase inhibitors, trans-2-phenylcyclopropylamine and isonicotinyl-2-isopropyl hydrazine. J. Pharmacol. exp. Ther. 129, 243–249 (1960).

    PubMed  CAS  Google Scholar 

  • Green, H., and J. Sawyer: Intracellular distribution of serotonin in rat brain. I. Effect of reserpine and the monoamine oxidase inhibitors, tranylcypromine and iproniazid. Arch. int. Pharmacodyn. 135, 426–441 (1962).

    CAS  Google Scholar 

  • Green, H., and J. Sawyer., and R. Erickson: Intracellular distribution of noradrenaline in rat brain. Pharmacol. Soc. Meet. Coral Gables. Florida 1959.

    Google Scholar 

  • Greengard, P., and G. P. Quinn: Metabolic effects of tranquilizers and hypophysectomy. In: D. V. Siva Sankar, Ed. Some biological aspects of schizophrenic behavior. Ann. N.Y. Acad. Sci. 96, Art, 1, 179–184 (1962).

    Google Scholar 

  • Gursey, D., and R. E. Olson: Depression of serotonin and norepinephrine levels in brain stem of rabbit by ethanol. Proc. Soc. exp. Biol. (N.Y.) 104, 280–281 (1960).

    CAS  Google Scholar 

  • Häggendal, J.: The presence of O-methylated noradrenaline (normetanephrine) in normal brain tissue. Acta physiol. scand. 59, 261–268 (1963).

    Google Scholar 

  • Häggendal, J., and M. Lindqvist: Ineffectiveness of ethanol on noradrenaline, dopamine or 5-hydroxy-tryptamine levels in brain. Acta pharmacol. (Kbh.) 18, 278–280 (1961).

    Google Scholar 

  • Häggendal, J., and M. Lindqvist: Behaviour and monoamine levels during long-term administration of reserpine to rabbits. Acta physiol. scand. 57, 431–436 (1963).

    PubMed  Google Scholar 

  • Häggendal, J., and M. Lindqvist: Disclosure of labile monoamine fractions in brain and their correlation to behaviour. Acta physiol. scand. 60, 351–357 (1964).

    Google Scholar 

  • Häggendal, J., and T. Malmfors: Evidence of dopamine-containing neurons in the retina of rabbits. Acta physiol. scand. 59, 295–296 (1963).

    Google Scholar 

  • Hamberger, B., T. Malmfors, K.-A. Norberg, and CH. Sachs: Uptake and accumulation of catecholamines in peripheral adrenergic neurons of reserpinized animals, studied with a histochemical method. Biochem. Pharmacol. 13, 841–844 (1964).

    PubMed  CAS  Google Scholar 

  • Hardisty, R. M., G. I. C. Ingram, and R. S. Stacey: Reserpine and human platelet 5-hydr-oxytryptamine. Experientia (Basel) 12, 424–425 (1956).

    CAS  Google Scholar 

  • Harrison, D. C., CH. A. Chidsey, R. Goldman, and E. Braunwald: Relationship between the release and tissue depletion of norepinephrine from the heart by guanethidine and reserpine. Circulat. Res. 12, 256–263 (1963).

    PubMed  CAS  Google Scholar 

  • Haverback, B. J., F. T. Dutscher, P. A. Shore, E. G. Tomich, L. L. Terry, and B. B. Brodie: Serotonin changes in platelets and brain induced by small daily doses of reserpine. New Engl. J. Med. 256, 343–345 (1957).

    PubMed  CAS  Google Scholar 

  • Haverback, B. J., P. A. Shore, E. G. Tomich, and B. B. Brodie: Cumulative effect of small doses of reserpine on serotonin in man. Fed. Proc. 15, 434–435 (1956).

    Google Scholar 

  • Haverback, B. J., and S.K. Wirtschaftler: The gastrointestinal tract and naturally occurring pharmacologically active amines. In: S. Garattini and P. A. Shore, Eds. Advanc. Pharmac. 1, 309–347 (1962).

    Google Scholar 

  • Hertting, G., J. Axelrod, and R. W. Patrick: Actions of bretylium and guanethidine on the uptake and release of 3H-noradrenaline. Brit. J. Pharmacol. 18, 161–166 (1962).

    PubMed  CAS  Google Scholar 

  • Hertting, G., J. Axelrod, and L. G. Whitby: Effect of drugs on the uptake and metabolism of H3-norepinephrine. J. Pharmacol. exp. Ther. 134, 146–153 (1961).

    CAS  Google Scholar 

  • Hertting, G., u. O. Hornykiewicz: Beeinflussung der durch Reserpin hervorgerufenen Nebennierenrinden-hypertrophie durch Cortison. Acta endocr. (Kbh.) 26, 204–208 (1957).

    CAS  Google Scholar 

  • Hertting, G., L. T. Potter, and J. Axelrod: Effect of decentralization and ganglionic blocking agents on the spontaneous release of H3-norepinephrine. J. Pharmacol. exp. Ther. 136, 289–292 (1962).

    PubMed  CAS  Google Scholar 

  • Hess, S. M., P. A. Shore, and B. B. Brodie: Persistence of reserpine action after the disappearance of drug from brain: effect on serotonin. J. Pharmacol. exp. Ther. 118, 84–89 (1956).

    PubMed  CAS  Google Scholar 

  • Higuchi, H.: Effects of intravenous and intracarotid administration of reserpine on catechol-amine contents of the brain, heart and adrenal gland in rabbit. Jap. J. Pharmacol. 12, 34–47 (1962).

    PubMed  CAS  Google Scholar 

  • Hillarp, N.-Å.: Further observations on the state of the catecholamines stored in the adrenal medullary granules, Acta physiol, scand. 47, 271–279 (1959).

    CAS  Google Scholar 

  • Hillabp, N,-Å.: Different pools of catecholamines stored in the adrenal medulla. Acta physiol. scand. 50, 8–22 (1960a).

    Google Scholar 

  • Hillabp, N,-Å.: Effect of reserpine on the adrenal medulla of sheep. Acta phvsiol. scand. 49, 376–382 (1960b).

    Google Scholar 

  • Hillabp, N,-Å., and T. Malmfors: Reserpine and cocaine blocking of uptake and storage mechanisms in adrenergic nerves. Life Sci. 3, 703–708 (1964).

    Google Scholar 

  • Holeček, V., V. Schreiber, and V. Kmentova: The influence of serpasil on the secretion of antidiuretic hormone. Cas., Lék. ces. 96, 1060–1062 (1957).

    Google Scholar 

  • Holtz, P., H. Balzer u. E. Westermann: Die Beeinflussung der Reserpinwirkung auf das Nebennierenmark durch Hemmung der Monoaminoxidase. Naunvn-Schmiedebergs Arch. exp. Path. Pharmak. 231, 361–372 (1957).

    CAS  Google Scholar 

  • Holzbauer, M., and M. Vogt: Depression by reserpine of the noradrenaline concentration in the hypothalamus of the cat. J. Neurochem. 1, 8–11 (1956).

    PubMed  CAS  Google Scholar 

  • Horita, A.: A vasopressor resporse to reserpine in the cocainized dog. J. Pharmacol. exp. Ther. 122, 474–479 (1958).

    PubMed  CAS  Google Scholar 

  • Hughes, P. B., and B. B. Brodie: The mechanism of serotonin and catecholamine uptake by platelets. J. Pharmacol. exp. Ther. 127, 96–102 (1959).

    PubMed  CAS  Google Scholar 

  • Hughes, P. B., P. A. Shore, and B. B. Brodie: Serotonin storage mechanism and its interaction with reserpine. Experientia (Basel) 14, 178 (1958).

    CAS  Google Scholar 

  • Hutchison, H. E., J. M. Stark, and J. A. Chapman: Platelet serotonin and normal haemostasis. J. clin. Path. 12, 265–267 (1959).

    PubMed  CAS  Google Scholar 

  • Iggo, A., and M. Vogt: Preganglionic sympathetic activity in normal and reserpine-treated cats. J. Physiol. (Lond.) 150, 114–133 (1960).

    CAS  Google Scholar 

  • Innes, I. R., O. Krayer, and D. R. Waud: The action of Rauwolfia alkaloids on the heart rate and on the functional refractory period of atrioventricular transmission in the heartlung preparation of the dog. J. Pharmacol. exp. Ther. 124, 324–332 (1958).

    PubMed  CAS  Google Scholar 

  • Izquierdo, J. A., J. D. Coussio, and A. J. Kaumann: Effect of imipramine on the pressor responses to the afferent vagal stimulation of reserpinized dogs. Arch. int. Pharmacodyn. 135, 303–310 (1962).

    CAS  Google Scholar 

  • Johnson, G. E., and E. A. Sellers: The effect of reserpine on the metabolic rate of rats. Canad. J. Biochem. 39, 279–285 (1961).

    PubMed  CAS  Google Scholar 

  • Jonasson, J., E. Rosengren, and B. Waldeck: Effects of some pharmacologically active amines on the uptake of arvlalkvlamines by adrenal medullary granules. Acta physiol. scand. 60, 136–140 (1964).

    PubMed  CAS  Google Scholar 

  • Kanematsu, S., J. Hilliard, and C. H. Sawyer: Effect of reserpine on pituitary prolactin content and its hypothalamic site of action in the rabbit. Acta endocr. (Kbh.) 44, 467–477 (1963).

    CAS  Google Scholar 

  • Kanematsu, S., and C. H. Sawyer: Effects of intrahypothalamic implants of reserpine on lactation and pituitary prolactin content in the rabbit. Proc. Soc. exp. Biol. (N.Y.) 113, 967–969 (1963).

    CAS  Google Scholar 

  • Kärki, N. T., and M. K. Paasonen: Selective depletion of noradrenaline and 5-hydroxytryptamine from rat brain and intestine by Rauwolfia alkaloids. J. Neurochem. 3, 352–357 (1959).

    PubMed  Google Scholar 

  • Kärki, N. T., and M. K. Paasonen: Presence of 5-hydroxytryptamine after raunescine in blood plasma in vivo. Nature (Lond.) 185, 109 (1960).

    Google Scholar 

  • Kärki, N. T., and M. K. Paasonen., and P. A. Vanhakartano: The influence of pentolonium, isoraunescine and yohimbine on the noradrenaline depleting action of reserpine. Acta pharmacol. (Kbh.) 16, 13–19 (1959).

    Google Scholar 

  • Kaul, C. L., and J. J. Lewis: The effects of reserpine and some related compounds upon the levels of adenine nucleotides, creatine phosphate and inorganic phosphate in the rat brain in vivo. J. Pharmacol. exp. Ther. 140, 111–116 (1963).

    PubMed  CAS  Google Scholar 

  • Khazan, N., J. Adir, Y. Pfeifer, and F. G. Sulman: Mechanism of antidiuretic action of reserpine. Proc. Soc. exp. Biol. (N.Y.) 109, 32–35 (1962).

    CAS  Google Scholar 

  • Khazan, N., and F. G. Sulman: Melanophore-dispersing activity of reserpine in Rana frogs. Proc. Soc. exp. Biol. (N.Y.) 107, 282–284 (1961).

    CAS  Google Scholar 

  • Khazan, N., and H. Z. Winnik: Activity of pituitary-adrenal cortex axis during acute and chronic reserpine treatment, Proc. Soc. exp. Biol. (N.Y.) 106, 579–581 (1961).

    CAS  Google Scholar 

  • Killam, E. K.: Drug action on the brain-stem reticular formation. Pharmacol. Rev. 14, 175–223 (1962).

    PubMed  CAS  Google Scholar 

  • Killam, K. F., and E. K. Killam: Central action of chlorpromazine and reserpine. In: H. A. Abrahamson, Ed., Neuropharmacology, Transactions of the Vth Conference, p. 131–198. New York: Josiah Macy, Jr. Foundation 1960.

    Google Scholar 

  • Kim, K. S., and P. A. Shore: Production of gastric lesions in the rat by insulin and reserpine: effect on gastric histamine and serotonin, Fed, Proc, 22, 276 (1963)

    Google Scholar 

  • Kiepekab, S. M., P. Cervoni, and R. F. Furchgott: Catecholamine content of the cat nictitating membrane following procedures sensitizing it to norepinephrine. J. Pharmacol. exp. Ther. 135, 180–190 (1962).

    Google Scholar 

  • Kiepekab, S. M., G. A. J. Goodlad, and J. J. Lewis: Reserpine depletion of adenosine triphosphate from the rat suprarenal medulla. Biochem. Pharmacol. 1, 232–233 (1958).

    Google Scholar 

  • Kiepekab, S. M., and J. J. Lewis: Some effects of reserpine and hydrallazine upon tissue respiration and the concentration of adenosine nucleotides in certain tissues. Brit. J. Pharmacol. 14, 40–45 (1959).

    Google Scholar 

  • Kiepekab, S. M., and J. J. Lewis: Effects of reserpine, chlorpromazine and sodium salicylate on the enzymic activity of rat liver. Brit. J. Pharmacol. 15, 175–180 (1960).

    Google Scholar 

  • Kirshner, N.: Uptake of catecholamines by a particulate fraction of the adrenal medulla. Science 135, 107–108 (1962a).

    PubMed  CAS  Google Scholar 

  • Kirshner, N.: Uptake of catecholamines by a particulate fraction of the adrenal medulla. J. biol. Chem. 237, 2311–2317 (1962b).

    PubMed  CAS  Google Scholar 

  • Kitay, J. L, D. A. Holub, and J. W. Jailer: “Inhibition” of pituitary ACTH release after administration of reserpine or epinephrine. Endocrinology 65, 548–554 (1959).

    PubMed  CAS  Google Scholar 

  • Knoll, J., and B. Knoll: Reserpine: modification of its tranquilizer effect and analysis of its central node of action. Arch. int. Pharmacodyn. 133, 310–326 (1961).

    CAS  Google Scholar 

  • Kohli, J. D., and B. Mukerji: Reserpine & Rauwolfia alkaloids-recent pharmacological studies. J. Sci. Ind. Res. 20 A, 69–87 (1961).

    Google Scholar 

  • Kopin, I. J., and E. K. Gordon: Metabolism of norepinephrine-H3 released by tyramine and reserpine. J. Pharmacol. exp. Ther. 138, 351–359 (1962).

    PubMed  CAS  Google Scholar 

  • Kopin, I. J., and E. K. Gordon: Metabolism of administered and drug-released norepinephrine-7-H3 in the rat. J. Pharmacol. exp. Ther. 140, 207–216 (1963).

    PubMed  CAS  Google Scholar 

  • Kroneberg, G., u. H. J. Schümann: Die Wirkung des Reserpins auf den Hormongehalt des Nebennierenmarks. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 231, 349–360 (1957).

    CAS  Google Scholar 

  • Kroneberg, G., u. H. J. Schümann: Adrenalinsekretion und Adrenalinverarmung der Kaninchennebennieren nach Reserpin. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 234, 133–146 (1958).

    CAS  Google Scholar 

  • Kroneberg, G., u. H. J. Schümann: Über die Bedeutung der Innervation für die Adrenalinsynthese im Nebennierenmark. Experientia (Basel) 15, 234 (1959).

    CAS  Google Scholar 

  • Kroneberg, G., u. H. J. Schümann: Der Einfluß von Iproniacid auf die durch Reserpin gesteigerte Sekretion des Kaninchennebennierenmarks. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 239, 29–34 (1960).

    CAS  Google Scholar 

  • Kuschinsky, G., R. Lindmar, H. Lüllmann u. E. Muscholl: Der Einfluß von Reserpin auf die Wirkung der „Neuro-Sympathomimetika“. Naunyn Schmiedebergs Arch. exp. Path. Pharmak. 240, 242–252 (1960).

    CAS  Google Scholar 

  • La Lande, I. S. De, V. J. Parks, A. G. Sandison, S. L. Skinner, and R. F. Whelan: The peripheral dilator action of reserpine in man. Aust. J. exp. Biol. med. Sci. 38, 313–320 (1960).

    Google Scholar 

  • Laverty, R.: The influence of cold environmental temperature and histamine treatment on the effect of reserpine in the rat. J. Neurochem. 10, 151–154 (1963).

    CAS  Google Scholar 

  • Lessin, A. W., and M. W. Parkes: The relation between sedation and body temperature in the mouse. Brit. J. Pharmacol. 12, 245–250 (1957).

    PubMed  CAS  Google Scholar 

  • Lessin, A. W., and M. W. Parkes: The effects of reserpine and other agents upon leptazol convulsions in mice. Brit. J. Pharmacol. 14, 108–111 (1959).

    PubMed  CAS  Google Scholar 

  • Leusen, I.: Monoamin-Freisetzer und Monoaminoxydase-Hemmer. Psychiat. et Neurol. (Basel) 140, 154–164 (1960).

    CAS  Google Scholar 

  • Leusen, I., E. Lacroix et G. Demeester: Quelques propriétés pharmacodynamiques de la tétra-bénazine, substance libératrice de sérotonine. Arch. int. Pharmacodyn. 119, 225–231 (1959).

    PubMed  CAS  Google Scholar 

  • Lewis, J. J.: Rauwolfia derivatives. In: W. S. Root and F. G. Hofmann, Eds., Physiological Pharmacology. A comprehensive treatise, vol. I. The nervous system-Part A. p. 479–536. New York: Academic Press 1963.

    Google Scholar 

  • Liebecq-Hutter, S., and Z. M. Bacq: Disappearance of 5-hydroxytryptamine in the granulations of the glands of the skin of Discoglossus pictus and of Rana temporaria after injection of reserpine. Experientia (Basel) 14, 180–181 (1958).

    CAS  Google Scholar 

  • Liebecq-Hutter, S., J. F. Renson et P. Fischer: Action de la réserpine sur la teneur en 5-hydroxytryptamine des tissus de Discoglossus pictus. Arch. int. Physiol. 67, 144–147 (1959).

    Google Scholar 

  • Liebman, J., A. J. Muskus, and O. R. Wattd: The depletion of norepinephrine stores in the heart of the dog by reserpine-type alkaloids. J. Pharmacol. exp. Ther. 136, 75–79 (1962).

    PubMed  CAS  Google Scholar 

  • Lundborg, P.: Storage function and amine levels of the adrenal medullary granules at various intervals after reserpine treatment. Experientia (Basel) 19, 479 (1963).

    CAS  Google Scholar 

  • Maclean, P. D.: Hippocampal studies: Their possible bearing on neuropsychiatry. Arch. Neurol. Psychiat. (Chic.) 74, 219–220 (1955).

    Google Scholar 

  • Magnusson, T., and E. Rosengren: Catecholamines of the spinal cord normally and after transection. Experientia (Basel) 19, 229–230 (1963).

    CAS  Google Scholar 

  • Maickel, R. P., E. O. Westermann, and B. B. Brodle: Effects of reserpine and cold-exposure on pituitary adrenocortical function in rats. J. Pharmacol. exp. Ther. 134, 167–175 (1962).

    Google Scholar 

  • Malhotra, C. L., and P. K. Das: Effect of reserpine on the acetylcholine content of the heart, the ileum and the hypothalamus of the dog. Brit. J. Pharmacol. 18, 190–193 (1962).

    PubMed  CAS  Google Scholar 

  • Malhotra, C. L., and K. Prasad: The effect of intra(cerebro)ventricular reserpine on the acetylcholine content of the heart, ileum and hypothalamus of the dog. Brit. J. Pharmacol. 21, 355–360 (1963).

    PubMed  CAS  Google Scholar 

  • Malhotra, C. L., and P. G. Pundlik: The effect of reserpine on the acetyl choline content of different areas of the nervous system of the dog. Brit. J. Pharmacol. 14, 46–47 (1959).

    PubMed  CAS  Google Scholar 

  • Malmfors, T.: Evidence of adrenergic neurons with synaptic terminals in the retina of rats demonstrated with fluorescence and electron microscopy. Acta physiol. scand. 58, 99–100 (1963).

    PubMed  CAS  Google Scholar 

  • Markiewicz, L.: Biochemical and functional effects of long-term administration of reserpine in mice. Acta physiol. scand. 58, 376–380 (1963).

    PubMed  CAS  Google Scholar 

  • Mathé, V., GY. Kassay u. K. Hunkar: Die Wirkung des Reserpins auf den Gehalt des Rattengehirns an gesamtreduzierenden Stoffen und Glykogen. Z. ges. exp. Med. 134, 249–253 (1961).

    PubMed  Google Scholar 

  • Maxwell, R. A., A. J. Plummer, M.W. Osborne, and S. D. Ross: Evidence for a peripheral action of reserpine. J. Pharmacol. exp. Ther. 116, 42 (1956).

    Google Scholar 

  • Maxwell, R. A., S. D. Ross, A. J. Plummer, and E. B. Sigg: A peripheral action of reserpine. J. Pharmacol. exp. Ther. 119, 69–77 (1957).

    PubMed  CAS  Google Scholar 

  • Mcdonald, R. K., and V. K. Weise: The effect of certain psychotropic drugs on the urinary excretion of 3-methoxv-4-hydroxvmandelic acid in man. J. Pharmacol. exp. Ther. 136, 26–30 (1962).

    CAS  Google Scholar 

  • Mcqueen, E.G., A. E. Doyle, and F. H. Smirk: Mechanism of hypotensive action of reserpine, an alkaloid of Rauwolfia serpentina. Nature (Lond.) 174, 1015 (1954).

    CAS  Google Scholar 

  • Mcqueen, E.G., A. E. Doyle, and F. H. Smirk: The circulatory effects of reserpine. Circulation 11, 161–169 (1955).

    PubMed  CAS  Google Scholar 

  • Meites, J.: Effect of reserpine on prolactin content of rabbit pituitary. Proc. Soc. exp. Biol. (N.Y.) 97, 742–744 (1958).

    CAS  Google Scholar 

  • Meites, J., C. S. Nicoll, and P. R. Talwalker: Effect of reserpine and serotonin on milk secretion and mammary growth in the rat. Proc. Soc. exp. Biol. (N.Y.) 101, 563–565 (1959).

    CAS  Google Scholar 

  • Miline, R., P. Stern, E. Serstnev et M. Muhibic: Effet de la réserpine et de la réserpine associée au luminal sur le complexe hypothalamo-hypophysaire. In: S. Garattini and V. Ghetti, Eds., Psychotropic Drugs, p. 332–349. Amsterdam: Elsevier Publ. Co. 1957.

    Google Scholar 

  • Mirkin, B. L.: Catechol aminé depletion in the rat’s denervated adrenal gland following chronic administration of reserpine. Nature (Lond.) 182, 113–114 (1958).

    CAS  Google Scholar 

  • Mirkin, B. L.: The effect of synaptic blocking agents on reserpine-induced alterations in adrenal medullary and urinary catecholamine levels. J. Pharmacol. exp. Ther. 133, 34–40 (1961).

    PubMed  CAS  Google Scholar 

  • Moore, K. E., and T. M. Brody: The effect of triethvltin on tissue amines. J. Pharmacol. exp. Ther. 132, 6–12 (1961).

    PubMed  CAS  Google Scholar 

  • Moran, N. C., and B. Westerholm: The influence of reserpine on 5-hydroxytryptamine and histamine content of rat mast cells and of some rat tissues. Acta physiol. scand. 58, 20–29 (1963).

    CAS  Google Scholar 

  • Müller, J. M., E. Schlittler u. H. J. Bein: Reserpin, der sedative Wirkstoff aus Rauwolfia serpentina BENTH. Experientia (Basel) 8, 338 (1952).

    Google Scholar 

  • Muscholl, E.: Die Hemmung der Noradrenalin-Aufnähme des Herzens durch Reserpin und die Wirkung von Tyramin. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 240, 234–241 (1960).

    CAS  Google Scholar 

  • Muscholl, E., and M. Vogt: Concentration of adrenaline in plasma of rabbits treated with reserpine. Brit. J. Pharmacol. 12, 532–535 (1957).

    PubMed  CAS  Google Scholar 

  • Muscholl, E., and M. Vogt: The action of reserpine on the peripheral sympathetic system. J. Physiol. (Lond.) 141, 132–155 (1958).

    CAS  Google Scholar 

  • Muskus, A. J.: Effect of pretreatment with reserpine and reserpine analogs on the response of isolated guinea-pig atria to tyramine. J. Pharmacol. exp. Ther. 138, 296–300 (1962).

    PubMed  CAS  Google Scholar 

  • Nasmyth, P. A.: An investigation of the action of tyramine and its interrelationship with the effects of other sympathomimetic amines. Brit. J. Pharmacol. 18, 65–75 (1962).

    PubMed  CAS  Google Scholar 

  • Nayler, W. G.: A direct effect of reserpine on ventricular contractility. J. Pharmacol. exp. Ther. 139, 222–229 (1963).

    PubMed  CAS  Google Scholar 

  • Necina, J.: Antagonism between α-methyl DOPA and reserpine. Life Sci. 1, 301–303 (1962).

    PubMed  CAS  Google Scholar 

  • Necina, J., and I. Krejci: On the role of serotonin and catecholamines in relation to some effects of reserpine, Biochem, Pharmacol. 8, 35 (1961).

    Google Scholar 

  • Numerof, P., M. Gordon, and J. M. Kelly: The metabolism of reserpine. I. Studies in the mouse with C14-labeled reserpine. J. Pharmacol. exp. Ther. 115, 427–431 (1955).

    PubMed  CAS  Google Scholar 

  • Orlans, F. B. H., and B. B. Brodie: A suggested effect on levels of catecholamine in brain produced by small doses of reserpine. Nature (Lond.) 187, 1034–1035 (1960).

    CAS  Google Scholar 

  • Orlans, F. B. H., K. F. Finger, and B. B. Brodie: Pharmacological consequences of the selective release of peripheral norepinephrine by syrosingopine (SU 3118). J. Pharmacol. exp. Ther. 128, 131–139 (1960).

    PubMed  CAS  Google Scholar 

  • Paasonen, M. K., and P. B. Dews: Effects of raunescine and isoraunescine on behaviour and on the 5-hydroxytryptamine and noradrenaline contents of brain. Brit. J. Pharmacol. 13, 84–88 (1958).

    PubMed  CAS  Google Scholar 

  • Paasonen, M. K., and O. Krayer: The release of norepinephrine from the mammalian heart by reserpine. J. Pharmacol. exp. Ther. 123, 153–160 (1958).

    PubMed  CAS  Google Scholar 

  • Paasonen, M. K., and O. Krayer: The content of noradrenaline and adrenaline in the rat heart after administration of Rauwolfia alkaloids. Experientia (Basel) 15, 75–76 (1959).

    CAS  Google Scholar 

  • Paasonen, M. K., and A. Pletscher: Increase of free 5-hydroxytryptamine in blood plasma by reserpine and a benzoquinolizine derivative. Experientia (Basel) 15, 477 (1959).

    CAS  Google Scholar 

  • Paasonen, M. K., and M. Vogt: The effect of drugs on the amounts of substance P and 5-hydroxytryptamine in mammalian brain. J. Physiol. (Lond.) 131, 617–626 (1956).

    CAS  Google Scholar 

  • Palm, D., H. Balzer u. P. Holtz: Reserpin und γ-Aminobuttersäuregehalt des Gehirns. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 241, 190–191 (1961).

    CAS  Google Scholar 

  • Parks, V. J., A. G. Sandison, S. L. Skinner, and R. F. Whelan: The mechanism of the vasodilator action of reserpine in man. Clin. Sci. 20, 289–295 (1961).

    PubMed  CAS  Google Scholar 

  • Parks, V. J., S. L. Skinner, and R. F. Whelan: Mechanisms in the return of vascular tone following sympathectomy in man. Circulat. Res. 9, 1026–1033 (1961).

    PubMed  CAS  Google Scholar 

  • Parratt, J. R., and G. B. West: Release of 5-hydroxytryptamine and histamine from tissues of the rat. J. Physiol. (Lond.) 137, 179–192 (1957).

    CAS  Google Scholar 

  • Paulsen, E. C., and S. M. Hess: The rate of synthesis of catecholamines following depletion in guinea pig brain and heart. J. Neurochem. 10, 453–459 (1963).

    PubMed  CAS  Google Scholar 

  • Peterfalvi, M., et R. Jequier: La 10-methoxy deserpidine. Étude pharmacologique. Arch. int. Pharmacodyn. 124, 237–254 (1960).

    PubMed  CAS  Google Scholar 

  • Piccinelli, D.: Effect of reserpine on indole-alkylamine and phenylalkylamine levels in tissues of lower vertebrates and molluscs. Arch. int. Pharmacodyn. 117, 452–459 (1958).

    PubMed  CAS  Google Scholar 

  • Pletscher, A.: Beeinflussung des 5-Hydroxytryptamin-Stoffwechsels im Gehirn durch Isonikotinsäurehydrazide. Experientia (Basel) 12, 479–480 (1956).

    CAS  Google Scholar 

  • Pletscher, A.: Topographical difference of the behaviour of 5-hydroxytryptamine in the gastric mucosa after reserpine administration. In: G.P. Lewis, Ed., 5-Hydroxytryptamine, p. 84–85. London: Pergamon Press 1957a.

    Google Scholar 

  • Pletscher, A.: Release of 5-hydroxytryptamine by benzoquinolizine derivatives with sedative action. Science 126, 507 (1957b).

    PubMed  CAS  Google Scholar 

  • Pletscher, A.: Alterations of monoamine metabolism caused by drugs acting on the central nervous system. In: N.S. Kline, Ed., Psychopharmacology frontiers, p. 395–401. Boston: Little, Brown & Co. 1959.

    Google Scholar 

  • Pletscher, A., H. Besendorf u. H. P. Bächtold: Benzo[a]chinolizine, eine neue Körperklasse mit Wirkung auf den 5-Hydroxytryptamin-und Noradrenalin-Stoffwechsel des Gehirns. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 232, 499–507 (1958).

    CAS  Google Scholar 

  • Pletscher, A., H. Besendorf, and K. F. Gey: Depression of norepinephrine and 5-hydroxytryptamine in the brain by benzoquinolizine derivatives. Science 129, 844 (1959).

    PubMed  CAS  Google Scholar 

  • Pletscher, A., H. Besendorf, F. A. Steiner, and K. F. Gey: The effect of 2-hydroxy-benzoquinolizines on cerebral 5-hydroxytryptamine, spontaneous locomotor activity, and ethanol hypnosis in mice. Med. exp. (Basel) 7, 15–20 (1962).

    CAS  Google Scholar 

  • Pletscher, A., A. Brossi, and K. F. Gey: Benzoquinolizine derivatives: a new class of monoamine decreasing drugs with psychotropic action. Int. Rev. Neurobiol. 4, 275–306 (1962).

    Google Scholar 

  • Pletscher, A., and K. F. Gey: Interference with the permeation of aromatic monoamines and amino acids in brain by chlorpromazine and chlorprothixene. In: W. D. M. Paton and P. Lindgren, Eds., Proc. of the First Intern. Pharmacol. Meeting, vol. 8. Pharmacological analysis of central nervous action, p. 75–84. Oxford: Pergamon Press 1962.

    Google Scholar 

  • Pletscher, A., and K. F. Gey., and E. Kunz: Accumulation of exogenous monoamines in brain in vivo and its alteration by drugs. Symposium on “Binding Sites of Brain Biogenic Amines”, held at Galesburg, Illinois, March 1963; Progress in Brain Research 8, 45–52 (1964).

    Google Scholar 

  • Pletscher, A., and K. F. Gey, u. P. Zeller: Monoaminoxidase-Hemmer. Biochemie, Chemie, Pharmakologie, Klinik. Fortschr. Arzneimittelforsch. 2, 417–590 (1960).

    PubMed  CAS  Google Scholar 

  • Pletscher, A., P. A. Shore, and B. B. Brodie: Serotonin release as a possible mechanism of reserpine action. Science 122, 374–375 (1955).

    PubMed  CAS  Google Scholar 

  • Pletscher, A., P. A. Shore, and B. B. Brodie: Serotonin as a mediator of reserpine action in brain. J. Pharmacol. exp. Ther. 116, 84–89 (1956).

    PubMed  CAS  Google Scholar 

  • Plummer, A. J., W. E. Barrett, R. A. Maxwell, D. Finocchio, R. A. Lucas, and A. E. Earl: Hypotensive properties of syrosingopine, SU-3118, an ester of methyl reserpate. Arch. int. Pharmacodyn. 119, 245–257 (1959).

    PubMed  CAS  Google Scholar 

  • Plummer, A. J., and R. Rutledge: The action of reserpine on the motility of the digestive tract. Amer. J. dig. Dis. 22, 337–342 (1955).

    PubMed  CAS  Google Scholar 

  • Plummer, A. J., A. Earl, J. A. Schneider, J. Trapold, and W. E. Barrett: Pharmacology of Rauivolfia alkaloids, including reserpine. Ann. N.Y. Acad. Sci. 59, 8–21 (1954).

    PubMed  CAS  Google Scholar 

  • Plummer, A. J., R. A. Maxwell, and A. E. Earl: The influence of Ritalin (methylphenidate) on the behavioral and circulatory effects of reserpine. Schweiz, med. Wschr. 14 (Suppl.), 370–372 (1957).

    Google Scholar 

  • Plummer, A. J., H. Sheppard, and A. R. Schulert: The metabolism of reserpine. In: S. Garattini and V. Ghetti, Eds., Psychotropic Drugs, p. 350–362 Amsterdam: Elsevier Publ. Co. 1957.

    Google Scholar 

  • Porter, C. C., J. A. Totaro, and C. A. Stone: Effect of 6-hydroxydopamine and some other compounds on the concentration of norepinephrine in the hearts of mice. J. Pharmacol. exp. Ther. 140, 308–316 (1963).

    PubMed  CAS  Google Scholar 

  • Potter, L. T., and J. Axelrod: Studies on the storage of norepinephrine and the effect of drugs. J. Pharmacol. exp. Ther. 140, 199–206 (1963).

    PubMed  CAS  Google Scholar 

  • Premachandra, B. N.: Reserpine and thyroid function in the fowl. Biochem. Pharmacol. 8, 104 (1961).

    Google Scholar 

  • Prockop, D. J., P. A. Shore, and B. B. Brodie: Anticonvulsant properties of monoamine oxidase inhibitors. Ann. N.Y. Acad. Sci. 80, 643–651 (1959).

    PubMed  CAS  Google Scholar 

  • Proosdij-Hertzema, E. G. Van, A. M. Akkerman, and D. K. De Jongh: A new hypotensive agent derived from serpentine. Arch. int. Pharmacodyn. 123, 168–178 (1959).

    Google Scholar 

  • Pscheidt, G. R.: Effects of reserpine and isocarboxazid in the frog. International Symposium on Problems of the Brain, held in Galesburg, Illinois, March 1 to 3, 1963.

    Google Scholar 

  • Pscheidt, G. R., G. W. Brune, and H. E. Himwich: Uniform response of biogenic amines to psychotropic drugs in selected schizophrenic patients. Fed. Proc. 20, 305 (1961).

    Google Scholar 

  • Pscheidt, G. R., and H. E. Himwich: Reserpine, monoamine oxidase inhibitors, and distribution of biogenic amines in monkey brain. Biochem. Pharmacol. 12, 65–71 (1963).

    PubMed  CAS  Google Scholar 

  • Quinn, G.P., and B.B. Brodie: Effect of chlorpromazine and reserpine on the central actions of morphine in the cat. Med. exp. (Basel) 4, 349–355 (1961).

    CAS  Google Scholar 

  • Pscheidt, G. R., M. B. Reid, and P. Greengard: Effect of tranquilizers and hypophysectomy on the response of liver DPN to nicotinamide administration. Fed. Proc. 21, 419 (1962).

    Google Scholar 

  • Pscheidt, G. R., P. A. Shore, and B. B. Brodie: Biochemical and pharmacological studies of Ro 1-9569 (tetrabenazine), a non-indole tranquilizing agent with reserpine-like effects. J. Pharmacol. exp. Ther. 127, 103–109 (1959).

    Google Scholar 

  • Randall, L. O., N. Atkinson, and V. Iliev: The effect of psychostimulants and psychodepressants on DPN synthesis in the liver. Arch. int. Pharmacodyn. 129, 434–437 (1960).

    PubMed  CAS  Google Scholar 

  • Reimert, H.: Role and origin of noradrenaline in the superior cervical ganglion. J. Physiol. (Lond.) 167, 18–29 (1963).

    Google Scholar 

  • Rinaldi, F., and H. E. Himwich: A comparison of effects of reserpine and some barbiturates on the electrical activity of cortical and sub cortical structures in the brain of rabbits. Ann. N.Y. Acad. Sci. 61, 27–35 (1955).

    PubMed  CAS  Google Scholar 

  • Robertis, E. De: Contribution of electronmicroscopy to neuropharmacological problems. Biochem. Pharmacol. 9, 49–60 (1962).

    Google Scholar 

  • Robertis, E. De: Electron microscope and chemical study of binding sites of brain biogenic amines. Symposium on “Binding Sites of Brain Biogenic Amines”, held at Galesburg, Illinois, March 1963; Progress in Brain Research 8, 118–136 (1964).

    Google Scholar 

  • Robison, M. M., R.A. Lucas, H. B. Macphillarmy, W.E. Barrett, and A.J. Plummer: Rauwolfia alkaloids. XXXV. Potent, fast-acting sedatives derived from methyl reserpate. Experientia (Basel) 17, 14–15 (1961).

    CAS  Google Scholar 

  • Roos, B.-E., and G. Steg: The effect of L-3,4-dihydroxyphenylalanine and DL-5-hydroxytryptophan on rigidity and tremor induced by reserpine, chlorpromazine and phenoxybenzamine. Life Sci. 3, 351–360 (1964).

    PubMed  CAS  Google Scholar 

  • Roos, B.-E., and B. Werdinius: Effect of reserpine on the level of 5-hydroxyindoleacetic acid in brain. Life Sci. No 3, 105–107 (1962).

    Google Scholar 

  • Rosell, S., and G. Sedvall: Restoration of vasoconstrictor effects in reserpinized cats. Acta physiol. scand. 53, 174–184 (1961).

    PubMed  CAS  Google Scholar 

  • Rosell, S., and G. Sedvall: The rate of disappearance of vasoconstrictor responses to sympathetic chain stimulation after reserpine treatment. Acta physiol. scand. 56, 306–314 (1962).

    PubMed  CAS  Google Scholar 

  • Ross, CH. A., H. C. Wenger, C. T. Ludden, and C. A. Stone: Selective potentiation of sympathomimetic amines by reserpine, syrosingopine and 2,6-xylylcholine ether bromide (TM-10) in the dog. Arch. int. Pharmacodyn. 142, 141–151 (1963).

    PubMed  CAS  Google Scholar 

  • Ross, S., and C. J. Carr: Behavioural pharmacology. In: E. S. E. Hafez, Ed., The Behaviour of Domestic Animals, p. 181–200. London: Bailliere, Tindall & Co. 1962.

    Google Scholar 

  • Rutishauser, M.: Beeinflussung des Kohlenhydratstoffwechsels des Rattenhirns durch Psychopharmaka mit sedativer Wirkung. Naunyn-Schmiedebergs Arch. exp. Path. Phannak. 245, 396–413 (1963).

    CAS  Google Scholar 

  • Saffron, M., and M. Vogt: Depletion of pituitary corticotrophin by reserpine and by a nitrogen mustard. Brit. J. Pharmacol. 15, 165–169 (1960).

    Google Scholar 

  • Sanan, S., and M. Vogt: Effect of drugs on the noradrenaline content of brain and peripheral tissues and its significance. Brit. J. Pharmacol. 18, 109–127 (1962).

    PubMed  CAS  Google Scholar 

  • Sano, I., Y. Kaktmoto, T. Okamoto, H. Nakajima u. Y. Ktjdo: Über 5-Oxyindolessigsäure-Ausscheidung im Urin von Schizophrenen mit Berücksichtigung des Einflusses von Chlorpromazin und Reserpin auf den Serotoninstoffwechsel. Schweiz. med. Wschr. 87, 214–217 (1957).

    PubMed  CAS  Google Scholar 

  • Sano, I., Y. Kaktmoto, and K. Taniguche: Binding and transport of serotonin in rabbit blood platelets and action of reserpine. Amer. J. Physiol. 195, 495–498 (1958).

    PubMed  CAS  Google Scholar 

  • Saxton, J. E.: The indole alkaloids. In: R. H. F. Manske, Ed., The alkaloids. Chemistry and physiology, vol. VII, p. 4–200. New York: Academic Press 1960.

    Google Scholar 

  • Schaepdryver A. F. De: Hypertensive responses in reserpinized dogs. Arch. int. Pharma-codyn. 124, 45–52 (1960).

    Google Scholar 

  • Schaepdryver, A. F. De., M. Bogaert, A. L. Delannois, A. L. Bernard, and P. Bernard: Peripheral noradrenergic reactivity. Arch. int. Pharmacodyn. 142, 243–259 (1963).

    Google Scholar 

  • Schapiro, H., and E. R. Woodward: The mechanism of action of reserpine on gastric secretion. Fed. Proc. 20, 248 (1961).

    Google Scholar 

  • Schlittler, E., J. Druey, and A. Marxer: Antihypertensive agents. Fortschr. Arznei-mittelforsch. 4, 295–352 (1962).

    CAS  Google Scholar 

  • Schneider, J. A.: Further characterization of central effects of reserpine (Serpasil), Amer. J. Physiol. 181, 64–68 (1955).

    CAS  Google Scholar 

  • Schneider, J. A.: The pharmacology of Rauwolfia. In: R. E. Woodson Jr., H. W. Youngken, E. Schlittler and J. A. Schneider. Rauwolfia: Botany, Pharmacognosy, Chemistry and Pharmacology, p. 109–144. Boston: Little, Brown & Co. 1957.

    Google Scholar 

  • Schneider, J. A., A. J. Plummer, A. E. Earl, W. E. Barrett, R. Rinehart, and R. C. Dibble: Pharmacological studies with deserpidine, a new alkaloid from Rauwolfia canescens. J. Pharmacol. exp. Ther. 114, 10–13 (1955).

    PubMed  CAS  Google Scholar 

  • Schneider, J. A., and R. K. Rinehart: Circulatory interactions of serotonin and reserpine (Serpasil) in dogs. Arch. int. Pharmacodyn. 105, 253–268 (1956).

    PubMed  CAS  Google Scholar 

  • Schümann, H. J.: Die Wirkung von Insulin und Reserpin auf den Adrenalin-und ATP-Gehalt der chromaffinen Granula des Nebennierenmarks. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 233, 237–249 (1958).

    Google Scholar 

  • Schwartz, D.E., A. Pletscher, K. F. Gey u. J. Rieder: Biologische Verteilung eines Benzochinolizinderivates und dessen Wirkung auf den 5-Hydroxytryptamin-und Noradrenalin-Gehalt der Gewebe. Helv. physiol. pharmacol. Acta 18, 10–16 (1960).

    PubMed  CAS  Google Scholar 

  • Seiden, L. S., and A. Carlsson: Temporary and partial antagonism by L-DOPA of reser-pine-induced suppression of a conditioned avoidance response. Psychopharmacologia (Berl.) 4, 418–423 (1963).

    CAS  Google Scholar 

  • Seiden, L. S., and A. Carlsson: Brain and heart catecholamine levels after L-DOPA administration in reserpine treated mice: correlations with conditioned avoidance response. Psychopharmacologia (Berl.) 5, 178–181 (1964).

    CAS  Google Scholar 

  • Shelburne, P. F., and E. S. Orgain: Comparison of syrosyngopine and reserpine in the treatment of ambulatory hypertensive patients. Amer. J. med. Sci. 245, 304–310 (1963).

    PubMed  CAS  Google Scholar 

  • Sheppard, H., R. A. Lucas, and W. H. Tsien: The metabolism of reserpine-C14. Arch. int. Pharmacodyn. 103, 256–269 (1955).

    PubMed  CAS  Google Scholar 

  • Sheppard, H., W. H. Tsien, E. B. Sigg, R. A. Lucas, and A. J. Plummer: The metabolism of reserpine-C14. III. C14-concentration vs. time in the brains and other tissues of rats and guinea pigs. Arch. int. Pharmacodyn. 113, 160–168 (1957).

    PubMed  CAS  Google Scholar 

  • Shore, P. A.: Release of serotonin and catecholamines by drugs. Pharmacol. Rev. 14, 531–550 (1962).

    PubMed  CAS  Google Scholar 

  • Shore, P. A., and B. B. Brodie: Influence of various drugs on serotonin and norepinephrine in brain. In: S. Garattini and V. Ghetti, Eds., Psychotropic Drugs, p. 423–427, Amsterdam: Elsevier Publ. Co. 1957a.

    Google Scholar 

  • Shore, P. A., and B. B. Brodie: LSD-like effects elicited by reserpine in rabbits pretreated with iproniazid. Proc. Soc. exp. Biol. (N.Y.) 94, 433–435 (1957b).

    CAS  Google Scholar 

  • Shore, P. A., A. Pletscher, and B. B. Brodie: Release of platelet serotonin by reserpine-effect on hemostasis. J. Pharmacol. exp. Ther. 116, 51–52 (1956).

    Google Scholar 

  • Shore, P. A., and B. B. Brodie., E. G. Tomich, R. Kuntzman, and B.B. Brodie: Release of blood platelet serotonin by reserpine and lack of effect on bleeding time. J. Pharmacol. exp. Ther. 117, 232–236 (1956).

    PubMed  CAS  Google Scholar 

  • Shore. P.A., S. L. Silver, and B. B. Brodie: Interaction of reserpine, serotonin, and lysergic acid diethylaniide in brain. Science 122, 284–285 (1955).

    PubMed  CAS  Google Scholar 

  • Smith, C. B., and P. B. Dews: Antagonism of locomotor suppressant effects of reserpine in mice. Psychopharmacologia (Berl.) 3, 55–59 (1962).

    CAS  Google Scholar 

  • Smith, E. R.: The effect of norepinephrine infusions upon some responses of reserpine-treated spinal cats to tyramine. J. Pharmacol. exp. Ther. 139, 321–329 (1963).

    PubMed  CAS  Google Scholar 

  • Spector, S., C. W. Hirsch, and B. B. Brodie: Association of behavioural effects of pargyline, a non-hydrazide MAO inhibitor, with increase in brain norepinephrine. Intern. J. Neuropharmacol. 2, 81–93 (1963).

    CAS  Google Scholar 

  • Spector, S., R. Kuntzman, P. A. Shore, and B. B. Brodie: Evidence for release of brain amines by reserpine in presence of monoamine oxidase inhibitors: implication of monoamine oxidase in norepinephrine metabolism in brain. J. Pharmacol. exp. Ther. 130, 256–261 (1960).

    CAS  Google Scholar 

  • Stacey, R. S.: 5-Hydroxytryptamine and other pharmacologically active substances in the central nervous system. Acta physiol. pharmacol. neerl. 8, 222–239 (1959).

    PubMed  CAS  Google Scholar 

  • Steg, G.: Efferent muscle innervation and rigidity. Acta physiol. scand. 61, Suppl. 225, 1–53 (1964).

    Google Scholar 

  • Stein, L., and O. S. Ray: Accelerated recovery from reserpine depression by monoamine oxidase inhibitors. Nature (Lond.) 188, 1199–1200 (1960).

    CAS  Google Scholar 

  • Stumpf, W., E. H. Graul u. H. Hundeshagen: Experimentelle Untersuchungen zur Pharmakologie des mit 3H-markierten Tetrabenazins. Arzneimittel-Forsch. 11, 47–49 (1961).

    CAS  Google Scholar 

  • Sulser, F., M. H. Bickel, and B. B. Brodie: On mechanism of the anti-depressant action of imipramine. In: W. D. M. Paton and P. Lindgren Eds., Proc. of the First Intern. Pharmacol. Meeting, vol. 8, Pharmacological analysis of central nervous action, p. 123–129. Oxford: Pergamon Press 1962.

    Google Scholar 

  • Sulser, F., and B. B. Brodie: IS reserpine tranquilization linked to change in brain serotonin or brain norepinephrine? Science 131, 1440–1441 (1960).

    PubMed  CAS  Google Scholar 

  • Szporny, L., and P. Görög: The effect of vincamine on the blood pressure of the rat. Arch. int. Pharmacodyn. 138, 451–461 (1962).

    PubMed  CAS  Google Scholar 

  • Taketomo, Y., P.A. Shore, E. G. Tomich, R. Kuntzman, and B. B. Brodie: Studies on the mechanism of reserpine-induced epinephrine release and hyperglycemia. J. Pharmacol. exp. Ther. 119, 188 (1957).

    Google Scholar 

  • Taylor jr. R. E., and M. J. Fregly: Effect of reserpine on body temperature regulation of the rat. J. Pharmacol. exp. Ther. 138, 200–207 (1962).

    CAS  Google Scholar 

  • Todrick, H., M. Dick, and A. C. Tait: Effect of reserpine in therapeutic dosage on excretion of 5-hydroxyindoleacetic acid. Brit. med. J. 1958 I, 496–499.

    Google Scholar 

  • Toman, J. E. P.: Some aspects of central nervous pharmacology. Ann. Rev. Pharmacol. 3, 153–184 (1963).

    Google Scholar 

  • Trendelenburg, U.: Modification of the effect of tyramine by various agents and procedures. J. Pharmacol. exp. Ther. 134, 8–17 (1961).

    PubMed  CAS  Google Scholar 

  • Trendelenburg, U.: Supersensitivity and subsensitivitv to sympathomimetic amines. Pharmacol. Rev. 15, 225–276 (1963).

    PubMed  CAS  Google Scholar 

  • Udenfriend, S., H. Weissbach, and D. F. Bogdanski: Increase in tissue serotonin following administration of its precursor 5-hydroxytryptophan. J. biol. Chem. 224, 803–810 (1957).

    PubMed  CAS  Google Scholar 

  • Uhr, L., and J. G. Miller (Eds.): Drugs and behavior. New York: John Wiley & Sons, Inc 1960.

    Google Scholar 

  • Valcourt, A. J.: Excretion of 5-hydroxyindoleacetic acid in mental patients. Arch. Neurol. Psychiat. (Chic.) 81, 292–298 (1959).

    CAS  Google Scholar 

  • Velluz, L., M. Peterfalvi, and R. Jequier: Separation of reserpine effects. C. R. Acad. Sci. (Paris) 247, 1905–1907 (1958).

    CAS  Google Scholar 

  • Volle, R. L.: Pharmacology of the autonomic nervous svstem. Ann. Rev. Pharmacol. 3, 129–152 (1963).

    Google Scholar 

  • Waalkes, T. P., H. Coburn, and L. L. Terry: The effect of reserpine on histamine and serotonin. J. Allergy 30, 408–414 (1959).

    CAS  Google Scholar 

  • Waalkes, T. P., and H. Weissbach: In vivo release of histamine from rabbit blood by reserpine. Proc. Soc. exp. Biol. (N.Y.) 93, 394–396 (1956).

    CAS  Google Scholar 

  • Waalkes, T. P., J. Bozicevich, and S. Udenfriend: Further studies on release of serotonin and histamine during anaphylaxis in the rabbit. Proc. exp. Biol. (N.Y.) 95, 479–482 (1957).

    CAS  Google Scholar 

  • Walaszek, E. J., and H. Burford: Modification of the vasopressor effect of tryptamine and tyramine by reserpine. Arch. int. Pharmacodyn. 143, 543–549 (1963).

    PubMed  CAS  Google Scholar 

  • Weil-Malherbe, H., and A.D. Bone: Intracellular distribution of catecholamines in the brain. Nature (Lond.) 180, 1050–1051 (1957).

    CAS  Google Scholar 

  • Weil-Malherbe, H., H. S. Posner, and G. R. Bowles: Changes in the concentration and intracellular distribution of brain catecholamines: the effects of reserpine, ß-phenylisopropylhydrazine. pyrogallol, and 3,4-dihydroxyphenylalanine, alone and in combination. J. Pharmacol. exp. Ther. 132, 278–286 (1961).

    PubMed  CAS  Google Scholar 

  • Weiner, M., and S. Udenfriend: Relation of platelet serotonin to disturbances of clotting and hemostasis. Circulation 15, 353–357 (1957).

    PubMed  CAS  Google Scholar 

  • Weiner, M., M. Perkins, and R. L. Sidman: Effect of reserpine on noradrenaline content of innervated and denervated brown adipose tissue of the rat. Nature (Lond.) 193, 137–138 (1962).

    CAS  Google Scholar 

  • Weissbach, H., B. G. Redfield, and E. Titus: Effect of cardiac glycosides and inorganic ions on binding of serotonin by platelets. Nature (Lond.) 185, 99–100 (1960).

    CAS  Google Scholar 

  • Weissman, A., and K. F. Finger: Effects of benzquinamide on avoidance behaviour and brain amine levels. Biochem. Pharmacol. 11, 871–880 (1962).

    PubMed  CAS  Google Scholar 

  • Wells, H., N. Briggs, and P. L. Munson: The inhibitory effect of reserpine on ACTH secretion in response to stressful stimuli. Endocrinology 59, 571–579 (1956).

    PubMed  CAS  Google Scholar 

  • Werdinitjs, B.: Effect of temperature on the action of reserpine. Acta pharmacol. (Kbh.) 19, 43–46 (1962).

    Google Scholar 

  • Westermann, E., R. P. Maickel u. B. B. Brodie: Untersuchungen über den Mechanismus einer Reserpinwirkung auf die Hypophyse. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 241, 189–190 (1961).

    CAS  Google Scholar 

  • Whelan, R. F., and S. L. Skinner: Autonomic transmitter mechanisms. In Peripheral Circulation in Man. Brit. med. Bull. 19, 120–124 (1963).

    CAS  Google Scholar 

  • Whittaker, V. P.: Investigations on the storage sites of biogenic amines in the central nervous system. Symposium on “Binding Sites of Brain Biogenic Amines”, held at Galesburg, Illinois, March 1963; Progress in Brain Research 8, 90–117 (1964).

    Google Scholar 

  • Williams, C. M.: The effect of reserpine on dopamine metabolism in humans. J. Neuro-chem. 9, 335–336 (1962).

    CAS  Google Scholar 

  • Wilson, C. W. M., A. W. Murray and E. Titus: Effects of reserpine on uptake of adrenaline in brain and certain areas outside the blood-brain barrier. J. Pharmacol. exp. Ther. 135, 11–16 (1962).

    PubMed  CAS  Google Scholar 

  • Withrington, P., and E. Zaimis: The reserpine-treated cat. Brit. J. Pharmacol. 17, 390–391 (1961).

    Google Scholar 

  • Woodson jr. R. E., H. W. Youngken, E. Schüttler, and J.A. Schneider: Rauwolfia. Botany, pharmacognosy, chemistry and pharmacology. Boston: Little, Brown & Co. 1957.

    Google Scholar 

  • Yamazaki, E., D. W. Slingerland, and A. Noguchi: The effect of reserpine on thyroxine degradation and thyrotrophin secretion. Acta endocr. (Kbh.) 36, 319–326 (1961).

    CAS  Google Scholar 

  • Zaimis, E.: The reserpine-induced circulatory failure. Nature (Lond.) 192, 521–523 (1961).

    CAS  Google Scholar 

  • Zbinden, G., A. Pletscher u. A. Studer: Regionäre Unterschiede der Reserpinwirkung auf enterochromaffine Zellen und 5-Hydroxytryptamin-Gehalt im Magendarmtrakt. Schweiz, med. Wschr. 87, 629–630 (1957a).

    CAS  Google Scholar 

  • Zbinden, G., A. Pletscher u. A. Studer: Hemmung der Reserpin-bedingten 5-Hydroxytryptamin-Freisetzung im entero-chromaffinen System durch Isopropyl-isonicotinsäurehydrazid. Klin. Wschr. 33, 565–567 (1957b).

    Google Scholar 

  • Zbinden, G., u. A. Studer: Histochemische Untersuchungen über den Einfluß von Iproniazid (Marsilid) auf die durch Reserpin erzeugte Freisetzung von Adrenalin und Noradrenalin aus dem Nebennierenmark. Experientia (Basel) 14, 201 (1958).

    CAS  Google Scholar 

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  1. Arvid Carlsson
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Vittorio Erspamer

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Carlsson, A. (1966). Drugs which block the storage of 5-hydroxytryptamine and related amines. In: Erspamer, V. (eds) 5-Hydroxytryptamine and Related Indolealkylamines. Handbook of Experimental Pharmacology/Handbuch der experimentellen Pharmakologie, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85467-5_11

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