Abstract
Recent interest in the hydrodynamic events relating to biomedical problems of the arteries as well as the development of artificial heart-assist devices have prompted one to study the nature of pulsatile flows in arteries. In particular, the problem of atherosclerosis is suspected to be related to the shearing stress developed over the vascular wall. The endothelial cells which normally line the intima of blood vessels can be eroded under high wall shear. It was found by Fry [1] that these cells have an acute yield stress of the order of 350 to 400 dynes/ cm2. Shearing stresses exceeding this limit will cause marked endothelial proliferation and subendothelial lipid deposition. On the other hand, there are problems of keeping the shearing stresses within a range to permit the endothelial cells to establish and to stabilize the newly formed fibrin surfaces over prostheses such as heart valves and heart-assist devices. Basic understanding of these problems could be gained through detailed knowledge of the pulsatile flow fields.
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© 1969 Springer-Verlag Berlin Heidelberg
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Ling, S.C., Atabek, H.B., Carmody, J.J. (1969). Pulsatile flows in arteries. In: Hetényi, M., Vincenti, W.G. (eds) Applied Mechanics. International Union of Theoretical and Applied Mechanics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85640-2_21
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DOI: https://doi.org/10.1007/978-3-642-85640-2_21
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