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Review of Flunarizine in Epilepsy

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Cerebral Ischemia and Calcium

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Abstract

A feature of epileptogenesis is burst firing of individual neurons. The burst comprises a slow paroxysmal depolarizing ion shift (PDS) upon which is superimposed a train of action potentials [6, 36]. Bursting depends largely on influx of Ca2+, although other ionic currents are also involved [37, 56].

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Author information

Authors and Affiliations

  1. The Maudsley Hospital, Denmark Hill, London, SE5 8AZ, UK

    C. D. Binnie

  2. Janssen Pharmaceutica B.V., B-Beerse, Belgium

    F. de Beukelaar

  3. Instituut voor Epilepsiebestrijding, Achterweg 5, NL-2103 SW, Heemstede, The Netherlands

    J. Overweg

Authors
  1. C. D. Binnie
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  2. F. de Beukelaar
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  3. J. Overweg
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Editor information

Editors and Affiliations

  1. Neurologische Universitätsklinik, Sigmund-Freud-Str. 25, D-5300, Bonn 1, Germany

    Alexander Hartmann

  2. Physiologisches Institut der Universität, Im Neuenheimer Feld 326, D-6900, Heidelberg, Germany

    Wolfgang Kuschinsky

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© 1989 Springer-Verlag Berlin Heidelberg

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Binnie, C.D., de Beukelaar, F., Overweg, J. (1989). Review of Flunarizine in Epilepsy. In: Hartmann, A., Kuschinsky, W. (eds) Cerebral Ischemia and Calcium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85863-5_61

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  • DOI: https://doi.org/10.1007/978-3-642-85863-5_61

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85865-9

  • Online ISBN: 978-3-642-85863-5

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