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Cyclic AMP, Cell Growth, and the Immune Response

Proceedings of the Symposium Held at Marco Island, Florida January 8–10, 1973

  • Conference proceedings
  • © 1974

Overview

Editors:
  1. Werner Braun
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  2. Lawrence M. Lichtenstein

    1. Department of Medicine, The Johns Hopkins University School of Medicine at The Good Samaritan Hospital, Baltimore, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Charles W. Parker

    1. Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, USA

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Table of contents (32 papers)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. A Tribute to Werner Braun

    • Eric L. Nelson
    Pages 1-3

  3. Regulatory Factors in the Immune Response: Analysis and Perspective

    • Werner Braun
    Pages 4-23

  4. The Cellular Basis of the Immune Response

    • Barry R. Bloom
    Pages 24-34

  5. Complexities in the Study of the Role of Cyclic Nucleotides in Lymphocyte Responses to Mitogens

    • Charles W. Parker
    Pages 35-44

  6. The Effect of Exogenous Nucleotides on the Response of Lymphocytes to PHA, PWM, and Con A

    • Rochelle Hirschhorn
    Pages 45-54

  7. Cyclic AMP in the Activation of Human Peripheral Blood Lymphocytes in Immunologically Deficient Patients and in Human Lymphoid Cell Lines

    • David R. Webb Jr., Daniel P. Stites, Janice Perlman, Kathryn E. Austin, H. Hugh Fudenberg
    Pages 55-76

  8. Mitogenic Activity of Polynucleotides on Thymus-Influenced Lymphocytes

    • Arthur G. Johnson, Ihn H. Han
    Pages 77-83

  9. Effects of Adenyl Cyclase-Stimulating Factors of Vibrio Cholerae on Antibody Formation

    • Richard A. Winchurch
    Pages 84-98

  10. Pharmacologic Regulation of Antibody Release in Vitro: Effects of Vasoactive Amines and Cyclic AMP

    • H. R. Bourne, K. L. Melmon, Y. Weinstein, G. M. Shearer
    Pages 99-113

  11. Leukocyte Separation on the Basis of their Receptors for Biogenic Amines and Prostaglandins: Relation of the Receptor to Antibody Formation

    • K. L. Melmon, Y. Weinstein, G. M. Shearer, H. R. Bourne
    Pages 114-134

  12. Separation of Leukocytes by their Amine Receptors: Subsequent Immunologic Functions

    • G. M. Shearer, Y. Weinstein, K. L. Melmon, H. R. Bourne
    Pages 135-146

  13. The Role of the Cyclic AMP System in Inflammation: An Introduction

    • Lawrence M. Lichtenstein
    Pages 147-162

  14. Hormonal Control of the Immunologic Release of Histamine and Slow-Reacting Substance of Anaphylaxis from Human Lung

    • Michael Kaliner, K. Frank Austen
    Pages 163-175

  15. Leucocytes as Secretory Organs of Inflammation: Control by Cyclic Nucleotides and Autonomic Agonists

    • Gerald Weissmann, Robert B. Zurier, Sylvia Hoffstein
    Pages 176-188

  16. The in Vivo Effect of Dibutyryl Cyclic AMP and Immunosuppressive Drugs on the Secondary Antibody Production of Mice to Ovalbumin

    • R. J. Perper, V. Blancuzzi, A. Oronsky
    Pages 189-194

  17. Relationships between the Cytolytic Activity of Thymus-Derived Lymphocytes and Cellular Cyclic Nucleotide Concentrations

    • Christopher S. Henney
    Pages 195-208

  18. Modulation of Cytotoxic T Lymphocyte Function by Cyclic 3′,5′-Mononucleotides

    • T. B. Strom, A. Deisseroth, J. Morganroth, C. B. Carpenter, J. P. Merrill
    Pages 209-222

  19. Cyclic GMP: Vestige or Another Intracellular Messenger?

    • Joel G. Hardman, Günter Schultz, Earl W. Sutherland
    Pages 223-236

  20. Cyclic GMP and Cyclic AMP in Lymphocyte Metabolism and Proliferation

    • John W. Hadden, Elga Hadden, Nelson D. Goldberg
    Pages 237-246
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Keywords

About this book

The brilliant research of Dr. Earl Sutherland and his colleagues has had a broad impact on many areas of biology. Among the fields in­ fluenced rather late by the insights arising from this work were im­ munology and oncology. Although research relating cyclic AMP metabol­ ism to the development and manifestations of the immune response and the control of mammalian cell growth is relatively recent, the growth of knowledge in these areas has been rapid and there is already a considera­ ble amount of empirical information. This conference provided an oppor­ tunity to collate and begin to interpret that information. A deliberate at­ tempt was made to bring together investigators nominally involved in im­ munology, biochemistry, pharmacology, or cellular biology for in many instances parallel observations are being obtained in these fields. For ex­ ample, the immunologist studying the transformation of lymphocytes by antigens or mitogens is carrying out experiments that are very close to those of the biologist studying the growth of cells in culture; in both cases, the phenomena they observe are modulated by changes in the in­ tracellular level of cyclic nucleotides. Many other examples of closely analogous experiments in different fields could be cited, but perhaps the point is clear.

Editors and Affiliations

  • Department of Medicine, The Johns Hopkins University School of Medicine at The Good Samaritan Hospital, Baltimore, USA

    Lawrence M. Lichtenstein

  • Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, USA

    Charles W. Parker

Bibliographic Information

  • Book Title: Cyclic AMP, Cell Growth, and the Immune Response

  • Book Subtitle: Proceedings of the Symposium Held at Marco Island, Florida January 8–10, 1973

  • Editors: Werner Braun, Lawrence M. Lichtenstein, Charles W. Parker

  • DOI: https://doi.org/10.1007/978-3-642-86026-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1974

  • Softcover ISBN: 978-3-642-86028-7Published: 23 August 2014

  • eBook ISBN: 978-3-642-86026-3Published: 09 November 2013

  • Edition Number: 1

  • Number of Pages: XV, 416

  • Number of Illustrations: 22 b/w illustrations

  • Topics: Medicine/Public Health, general

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