Abstract
The ability to study patterns of cerebral metabolism in humans noninvasively is clearly one of the great advantages of positron tomography. The development of the 18F-labeled 2-fluorodeoxyglucose (218FDG) method has produced a powerful tool for studying cerebral energy metabolism with positron tomography (Huang et al. 1980). Given the tight coupling normally existing between cerebral function and energy metabolism (Sokoloff 1977, 1981), 218FDG has been used to study resting patterns of metabolism in resting subjects (Mazziotta et al. 1981), subjects undergoing neuropsychological activations (Greenberg et al. 1981), and schizophrenic subjects at rest and off medication (Buchsbaum et al. 1982).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Abbreviations
- AMF:
-
Anterior medial frontal
- RAF:
-
Right anterior frontal
- LAF:
-
Left anterior frontal
- RPF:
-
Right posterior frontal
- LPF:
-
Left posterior frontal
- LRol:
-
Left rolandic
- RRol:
-
Right rolandic
- RAP:
-
Right anterior parietal
- LAP:
-
Left anterior parietal
- LPPO:
-
Left posterior parieto-occipital
- RPPO:
-
Right posterior parieto-occipital
- MMC:
-
Middle medial cortex
- MOP:
-
Medial occipitoparietal
- LP:
-
Left parietal
- RP:
-
Right parietal
- LO:
-
Left occipital
- RO:
-
Right occipital
- O:
-
Occipital
- RAT:
-
Right anterior temporal
- LAT:
-
Left anterior temporal
- RMT:
-
Right middle temporal
- LMT:
-
Left middle temporal
- RBG:
-
Right basal ganglia
- LBG:
-
Left basal ganglia
- RTh:
-
Right thalamus
- LTh:
-
Left thalamus
- LSyl:
-
Left sylvian
- RSy1:
-
Right sylvian
- LPT:
-
Left parietotemporal
- RPT:
-
Right parietotemporal
References
Buchsbaum MS, Davis GC, Coppola R, Naber R (1981) Opiate pharmacology and individual differences II. Somatosensory evoked potentials. Pain 10: 367–377
Buchsbaum MD, Ingvar DH, Kessler RM et al. (1982) Cerebral glucography with positron tomography in normals and patients with schizophrenia. Arch Gen Psychiatry 39: 251–259
Buchsbaum MS, Holcomb H, Kessler RM et al. (to be published) Lateralized asymmetries in glucose uptake assessed by positron emission tomography in patients with schizophrenia and normal controls. In: for-Henry P, GruzelierJ (eds) Hemispheric asymmetries of function in psychopathology, vol II. Elsevier Biomedical, Amsterdam
Davis GC, Buchsbaum MS, van Kammer DP, Bunney WE (1979) Analgesia to pain stimuli in schizophrenics and its reversal by naltrexone. Psychiatry Res 1: 61–70
Greenberg JH, Reivich M, Alavi A et al. (1981) Metabolic mapping of functional activity in human subjects with the 78F fluorodeomit-oxyglucose technique. Science 212: 678–680
Huang SC, Phelps ME, Hoffman EJ et al. (1980) Noninvasive determination of local cerebral metabolic rate of glucose in man. Am J Physiol 238 (Endocrinol Metab 1): E69 - E82
Ingvar DH (1980) Abnormal distribution of cerebral activity in chronic schizophrenia, a neuro-physiological interpretation. In: Baxter C, Melnechuk T (eds) Perspectives in schizophrenia research. Raven, New York
Ingvar DH, Rosen I, Elmquist D (1975) Effects of somatosensory stimulation upon rCBF. In: Harper M, Jennett B, Miller D, Rowan J (eds) Blood flow and metabolism in the brain. Churchill Livingstone, New York
Mazziotta JC, Phelps ME, Miller J, Kuhl DE (1981) Tomographic mapping of human cerebral metabolisms: normal unstimulated state. Neurology 31: 503–516
Peele TL (1981) The Neuroanatomic Basis for Clinical Neurology, 2nd edn. McGraw-Hill, New York
Sokoloff L (1977) Relation between physiological function and energy metablism in the central nervous system. J Neurochem 29: 13–26
Sokoloff L (1981) Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system. Fed Proc 40: 2311–2316
Sokoloff L, Reivich M, Kennedy C et al. (1977) The (14C) deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the concious and anaesthetized rat. J Neurochem 28: 897–916
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Kessler, R.M. et al. (1983). Regional Correlations in Patterns of Glucose Use in Patients with Schizophrenia and Normal Subjects During Mild Pain Stimulation. In: Heiss, WD., Phelps, M.E. (eds) Positron Emission Tomography of the Brain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95428-3_23
Download citation
DOI: https://doi.org/10.1007/978-3-642-95428-3_23
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-12130-5
Online ISBN: 978-3-642-95428-3
eBook Packages: Springer Book Archive