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Molecular Mechanisms of Membrane Traffic pp 145–157Cite as

CLIP-170, a Cytoplasmic Linker Protein Mediating Interaction of Endosomes with Microtubules

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Part of the book series: NATO ASI Series ((ASIH,volume 74))

Abstract

Microtubules play a key role in the dynamic spatial organization of the cytoplasmic matrix. They are involved in regulating the structure and positioning of intracellular organelles like the Golgi apparatus and endosomes, and they provide the tracks for directed movement of such organelles [Kreis, 1990]. Membrane-bounded cytoplasmic organelles attach to microtubules, move along or remain stably associated with them, and eventually detach. These interactions of organelles with microtubules appear to be specific. For example, endosomes, but not Golgi elements, reverse their direction of translocation along microtubules upon acidification of the cytoplasm [Heuser, 1989; Parton et al., 1991]. These various interactions require different levels of regulation; specificity and timing of binding and release, positioning, and direction of movement. We postulate, therefore, that different proteins must be involved in the regulation of these interactions of cytoplasmic organelles with microtubules.

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Authors and Affiliations

  1. European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, D-6900, Germany

    J. Scheel, J. E. Rickard, P. Pierre, D. Hennig, P. I. Karecla, R. Pepperkok, B. Joggerst-Thomalla, A. Sawyer, R. G. Parton & T. E. Kreis

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  1. J. Scheel
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  2. J. E. Rickard
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  3. P. Pierre
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  4. D. Hennig
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  5. P. I. Karecla
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  6. R. Pepperkok
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  7. B. Joggerst-Thomalla
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  8. A. Sawyer
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  9. R. G. Parton
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  10. T. E. Kreis
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Editor information

Editors and Affiliations

  1. Department of Medicinal Chemistry, HANS Life Science Research Building, Purdue University, West Lafayette, IN, USA

    D. James Morré

  2. C & S Biology, School of Medicine University of Colorado, Denver, CO, USA

    Kathryn E. Howell

  3. Department of Anatomy and Cell Biology, McGill University, H3A 2B2, Montreal, PQ, Canada

    John J. M. Bergeron

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© 1993 Springer-Verlag Berlin Heidelberg

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Scheel, J. et al. (1993). CLIP-170, a Cytoplasmic Linker Protein Mediating Interaction of Endosomes with Microtubules. In: Morré, D.J., Howell, K.E., Bergeron, J.J.M. (eds) Molecular Mechanisms of Membrane Traffic. NATO ASI Series, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02928-2_29

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  • DOI: https://doi.org/10.1007/978-3-662-02928-2_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-02930-5

  • Online ISBN: 978-3-662-02928-2

  • eBook Packages: Springer Book Archive

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