Skip to main content

L-α-Alanine Inhibition of Pyruvate Kinase from Tumours of the Human Central Nervous System

A New Aid in the Treatment of Gliomas

  • Chapter
Modern Neurosurgery 1

Abstract

There is ever-increasing literature pointing out that gene expression in tumour cells is different from that in normal cells from which or in which the tumour originates. In general, neoplasia is characterized by misprogramming of protein synthesis (16).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bennet, M.J., Timperley, W.R., Taylor, C.B., Hill, A.S.: Isozymes of hexokinase in the developing, normal and neoplastic human brain. Europ. J. Cancer 14, 189–193 (1978)

    Google Scholar 

  2. Deshpande, N., Mitchell, I., Millis, R.: Tumour enzymes and prognosis in human breast cancer. Europ. J. Cancer 17, 443–448 (1981)

    CAS  Google Scholar 

  3. Eigenbrodt, E., Glossmann, H.: Glycolysis — one of the keys to cancer? Trends Pharmacol. Sci. 1, 240–245 (1980)

    CAS  Google Scholar 

  4. Ibsen, K.H.: Interrelationships and functions of the pyruvate kinase isozymes and their variant forms: a review. Cancer Res. 37, 341–353 (1977)

    PubMed  CAS  Google Scholar 

  5. Ibsen, K.H., Fishman, W.H.: Developmental gene expression in cancer. Biochim. Biophys. Acta Cancer Rev. 560, 243–280 (1979)

    Article  CAS  Google Scholar 

  6. Knox, W.E., Linder, M., Friedel, G.H.: A series of transplantable rat mammary tumors with graded differentiation, growth rate and glutaminase content. Cancer Res. 30, 283–287 (1970)

    PubMed  CAS  Google Scholar 

  7. Marx, J.: Tumor viruses and the kinase connection. Science 211, 1336–1338 (1981)

    Article  PubMed  CAS  Google Scholar 

  8. Rabow, L., Kristansson, K.: Changes in lactate dehydrogenase isozyme patterns in patients with tumours of the central nervous system. Acta Neurochir. 36, 71–81 (1977)

    Article  PubMed  CAS  Google Scholar 

  9. Schapira, T.: Isozymes and cancer. Advan. Cancer Res. 18, 77–153 (1973)

    Article  CAS  Google Scholar 

  10. Tolle, S.W., Dyson, R.D., Newburgh, R.W., Cardenas, J.M.: Pyruvate kinase isozymes in neurons, glia, neuroblastoma and glioblastoma. J. Neurochem. 27, 1355–1360 (1976)

    Article  PubMed  CAS  Google Scholar 

  11. Van Veelen, C.W.M., Verbiest, H., Vlug, A.M.C., Rijksen, G., Staal, G.E.J.: Isozymes of pyruvate kinase from human brain maningiomas and malignant gliomas. Cancer Res. 38, 4681–4687 (1978)

    PubMed  Google Scholar 

  12. Van Veelen, C.W.M., Verbiest, H., Zülch, K.J., van Ketel, B.A., van der Vlist, M.J.M., Vlug, A.M. C., Rijksen, G., Staal, G.E.J.: L-0-alanine inhibition of pyruvate kinase from tumors of the human central nervous system. Cancer Res. 39, 4263–4269 (1979)

    PubMed  Google Scholar 

  13. Van Veelen, C.W.M., Rijksen, G., Vlug, A.M.C., Staal, G.E.J.: Correlation between alanine inhibition of pyruvate kinase and composition of K-M hybrids. Clin. Chim. Acta 110, 113–120 (1981)

    Article  PubMed  Google Scholar 

  14. Weber, G.: Enzymology of cancer cells. New. Engl. J. Med. 296, 486–493 (1977)

    Article  PubMed  CAS  Google Scholar 

  15. Weinhouse, S.: Metabolism and isozyme alterations in experimental hepatomas. Fed. Proc. 32, 2162–2167 (1973)

    PubMed  CAS  Google Scholar 

  16. Weinhouse, S.: Molecular mechanism of gene regulation. Cancer 36, 4330–4331 (1976)

    CAS  Google Scholar 

  17. Weinhouse, S.: New dimensions in the biology of cancer. Cancer 45, 2975–2980 (1980)

    Article  PubMed  CAS  Google Scholar 

  18. Zülch, K.J.: Principles of the new WHO classification of brain tumors. J. Neurosurg. Sci. 22, 1–5 (1978)

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

van Veelen, C.W.M. et al. (1982). L-α-Alanine Inhibition of Pyruvate Kinase from Tumours of the Human Central Nervous System. In: Brock, M. (eds) Modern Neurosurgery 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08801-2_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-08801-2_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-08803-6

  • Online ISBN: 978-3-662-08801-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics