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The Stability and Reversibility of Th1 and Th2 Populations

  • Chapter
Redirection of Th1 and Th2 Responses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 238))

Abstract

It has become widely accepted in the past decade that Th1 and Th2 cells represent alternate states of function and gene expression of CD41 T cells (Mosmann and Coffman 1989; Abbas et al. 1996). A question central to understanding the relevance of these subsets is whether they are products of an irreversible differentiation process or whether Th1 and Th2 cytokine patterns can be interchanged in an ordered or a regulated manner. Many disease states can be attributed to the activity of one specific Th subset, such as Th1-mediated autoimmune diseases or Th2-mediated allergic diseases and this implies that the ability to alter or reverse Th differentiation is a potential strategy for the treatment of such diseases.

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Authors and Affiliations

  1. Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA, 94304, USA

    R. L. Coffman, S. Mocci & A. O’Garra

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  1. R. L. Coffman
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  2. S. Mocci
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  3. A. O’Garra
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Editors and Affiliations

  1. DNAX Research Institute of Molecular and Cellular Biology, Inc., 901 California Avenue, 94304-1104, Palo Alto, CA, USA

    Robert L. Coffman Ph.D.

  2. Cattedra di Immunologia Clinica e Allergologia, Istituto di Clinica Medica III, Servizio di Immunoallergologia Viale Morgagni, 85, I-50134, Firenze, Italy

    Sergio Romagnani M.D. (Head) (Head)

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© 1999 Springer-Verlag Berlin Heidelberg

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Coffman, R.L., Mocci, S., O’Garra, A. (1999). The Stability and Reversibility of Th1 and Th2 Populations. In: Coffman, R.L., Romagnani, S. (eds) Redirection of Th1 and Th2 Responses. Current Topics in Microbiology and Immunology, vol 238. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09709-0_1

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  • DOI: https://doi.org/10.1007/978-3-662-09709-0_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-09711-3

  • Online ISBN: 978-3-662-09709-0

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