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Programmed Cell Death in Virus Infections of the Nervous System

  • Chapter
The Mechanisms of Neuronal Damage in Virus Infections of the Nervous System

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 253))

Abstract

Apoptosis is the term originally coined by Kerr, Wyllie and Currie (1972) to describe the ‘silent’ disposal of cells in tissues. It is a description of the morphology adopted by cells dying in normal physiological contexts, a process evolved for the removal of superfluous, unwanted and damaged cells during embryogenesis but also in mature tissues. Apoptosis occurs in nearly all cell types at one stage or another during the embryogenesis of multicellular organisms. The processes of involution and regression require apoptosis and classical examples are the death of interdigital mesenchymal cells during vertebrate limb development and the formation of kidney glomeruli. Apoptosis is essential in mature organ systems, for example during spermatogenesis, in the regression of the corpus luteum post-ovulation, in the turnover of specialised secretory epithelial cells lining the small intestine and in the resolution of inflammatory responses.

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Authors and Affiliations

  1. Laboratory for Clinical and Molecular Virology and Fujisawa Institute of Neuroscience, University of Edinburgh, Edinburgh, UK

    J. K. Fazakerley & T. E. Allsopp

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  1. J. K. Fazakerley
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  2. T. E. Allsopp
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  1. Universitätsklinikum Benjamin Franklin Abt. für Neuropathologie, FU Berlin, Fachbereich Humanmedizin, Hindenburgdamm 30, D-12200, Berlin, Germany

    Georg Gosztonyi M.D., Ph.D.

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Fazakerley, J.K., Allsopp, T.E. (2001). Programmed Cell Death in Virus Infections of the Nervous System. In: Gosztonyi, G. (eds) The Mechanisms of Neuronal Damage in Virus Infections of the Nervous System. Current Topics in Microbiology and Immunology, vol 253. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10356-2_5

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  • DOI: https://doi.org/10.1007/978-3-662-10356-2_5

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