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The Morphology of the Peritoneum in CAPD Patients

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Frontiers in Peritoneal Dialysis

Summary

The structure of the peritoneum has been studied by scanning and transmission electron microscopy and by light microscopy in 38 biopsies of 22 patients undergoing CAPD. Before CAPD the mesothelium was characterized by flattened cells with protruding nuclei, numerous microvilli and many pinocytotic vesicles. After prolonged CAPD there is a reduction and subsequent disappearance of microvilli and a vacuolar separation of cells from the basement membrane, accompanied by widening of intercellular junctions. Neither ultrafiltration rate nor small solute clearance change with these structural alterations. During peritonitis there is extensive cellular necrosis with denuding of the basement membrane. After recovery the mesothelium is replaced by thick fibrous connective tissue.

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Author information

Authors and Affiliations

  1. Nephrology and Dialysis Departments of Siena and Perugia, and the Anatomy and Histology Institutes, University of Siena, Italy

    N. DiPaolo, G. Sacchi, U. Buoncristiani, P. Rossi, E. Gaggiotti, C. Alessandrini, L. Ibba & A. M. Pucci

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  1. N. DiPaolo
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  2. G. Sacchi
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  3. U. Buoncristiani
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  4. P. Rossi
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  5. E. Gaggiotti
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  6. C. Alessandrini
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  7. L. Ibba
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  8. A. M. Pucci
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Editor information

Editors and Affiliations

  1. Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

    John F. Maher M.D. (Professor of Medicine) (Professor of Medicine)

  2. Georgetown University Medical Center, Washington, D.C., USA

    James F. Winchester M.D. (Associate Professor of Medicine) (Associate Professor of Medicine)

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© 1986 Springer-Verlag Berlin Heidelberg

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DiPaolo, N. et al. (1986). The Morphology of the Peritoneum in CAPD Patients. In: Maher, J.F., Winchester, J.F. (eds) Frontiers in Peritoneal Dialysis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-11784-2_2

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  • DOI: https://doi.org/10.1007/978-3-662-11784-2_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-11786-6

  • Online ISBN: 978-3-662-11784-2

  • eBook Packages: Springer Book Archive

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