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Ceramide, a Mediator of Cytosine Arabinoside Induced Apoptosis

  • Chapter
Sphingolipid-Mediated Signal Transduction

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Many diseases including cancer arise from alterations in signaling pathways. The cellular machinery controlling whether a cell is quiescent, proliferates, differentiates, or dies is no longer “correctly” regulated in transformed cells.1 However, some cancer cells retain the ability to undergo differentiation and cell death (primarily those cells of the hematopoietic and immune systems). The signaling mechanisms by which current anticancer agents induce differentiation and cell death are not completely understood. However, because of their central role in controlling cell growth and differentiation these signaling pathways are attractive targets for the improvement of therapy regimens and the development of new drugs.2,3 It is our aim to determine the signaling pathways in response to chemotherapeutic agents with the goal of developing more effective drugs and new combinations of existing drugs.

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  1. Susan P. Whitman
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  2. Larry W. Daniel
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Whitman, S.P., Daniel, L.W. (1997). Ceramide, a Mediator of Cytosine Arabinoside Induced Apoptosis. In: Sphingolipid-Mediated Signal Transduction. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22425-0_6

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  • DOI: https://doi.org/10.1007/978-3-662-22425-0_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22427-4

  • Online ISBN: 978-3-662-22425-0

  • eBook Packages: Springer Book Archive

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