Skip to main content

Chirurgie von primären Lungentumoren bei alten Patienten

  • Chapter
  • First Online:
Onkologische Chirurgie bei alten Patienten
  • 1090 Accesses

Zusammenfassung

Aufgrund von Limitierungen der pulmonalen und kardio-vaskulären Reserven, sowie zusätzlicher Komorbiditäten bei älteren Patienten, steigt das Risiko hinsichtlich der Morbidität und Mortalität nach Tumorresektionen der Lunge an. Durch eine umfassende Risikostratifizierung (Prüfung der kardio-pulmonalen Funktion), eine perioperative pulmonale Rehabilitation und eine schonende Operationstechnik (parenchymsparende, minimal-invasive Technik) sowie zusätzlich eine angepasste anästhesiologische und intensivmedizinische Betreuung, können vergleichbare Ergebnisse wie bei jüngeren Patienten erreicht werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 19.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 29.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Amer K et al (2012) Is it safe to include octogenarians at the start of a video-assisted thoracic surgery lobectomy program? Eur J Cardiothorac Surg 41(2):346–352

    Article  PubMed  Google Scholar 

  • Bals R, Lorenz J (2004) Checkliste XXL Pneumologie. 2. Auflage. Stuttgart, Thieme

    Google Scholar 

  • Berry MF et al (2011) A model for morbidity after lung resection in octogenarians. Eur J Cardiothorac Surg 39(6):989–994

    Article  PubMed  PubMed Central  Google Scholar 

  • Birim O et al (2003) Lung resection for non-small-cell lung cancer in patients older than 70: mortality, morbidity, and late survival compared with the general population. Ann Thorac Surg 76(6):1796–1801

    Article  PubMed  Google Scholar 

  • Bolukbas S, Eberlein MH, Schirren J (2011) Pneumonectomy vs. sleeve resection for non-small cell lung carcinoma in the elderly: analysis of short-term and long-term results. Thorac Cardiovasc Surg 59(3):142–147

    CAS  PubMed  Google Scholar 

  • Booth CM et al (2010) Adoption of adjuvant chemotherapy for non-small-cell lung cancer: a population-based outcomes study. J Clin Oncol 28(21):3472–3478

    Article  PubMed  PubMed Central  Google Scholar 

  • Brahmer J et al (2015) Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. N Engl J Med 373(2):123–135

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brokx HA et al (2007) Surgical treatment for octogenarians with lung cancer: results from a population-based series of 124 patients. J Thorac Oncol 2(11):1013–1017

    Article  PubMed  Google Scholar 

  • Brunelli A et al (2009) ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy). Eur Respir J 34(1):17–41

    Article  CAS  PubMed  Google Scholar 

  • Brunelli A et al (2013) Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 143(5 Suppl): e166S–90S

    Google Scholar 

  • Bryant AS, Cerfolio RJ (2008) Differences in outcomes between younger and older patients with non-small cell lung cancer. Ann Thorac Surg 85(5):1735–1739; discussion 1739

    Article  PubMed  Google Scholar 

  • Castillo MD, Heerdt PM (2007) Pulmonary resection in the elderly. Curr Opin Anaesthesiol 20(1):4–9

    Article  PubMed  Google Scholar 

  • Cerfolio RJ, Bryant AS (2006) Survival and outcomes of pulmonary resection for non-small cell lung cancer in the elderly: a nested case-control study. Ann Thorac Surg 82(2):424–429; discussion 429–430

    Article  PubMed  Google Scholar 

  • Chambers A et al (2010) In elderly patients with lung cancer is resection justified in terms of morbidity, mortality and residual quality of life? Interact Cardiovasc Thorac Surg 10(6):1015–1021

    Article  PubMed  Google Scholar 

  • Choi YL et al (2010) EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med 363(18):1734–1739

    Article  CAS  PubMed  Google Scholar 

  • Colice GL et al (2007) Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: ACCP evidenced-based clinical practice guidelines (2nd edition). Chest 132(3 Suppl):161s–177s

    Google Scholar 

  • Cuffe S et al (2012) Adjuvant chemotherapy for non-small-cell lung cancer in the elderly: a population-based study in Ontario, Canada. J Clin Oncol 30(15):1813–1821

    Article  PubMed  Google Scholar 

  • D′Angelo SP et al (2011) Incidence of EGFR exon 19 deletions and L858R in tumor specimens from men and cigarette smokers with lung adenocarcinomas. J Clin Oncol 29(15):2066–2070

    Article  PubMed  PubMed Central  Google Scholar 

  • Dell′Amore A et al (2013) Early and long-term results of pulmonary resection for non-small-cell lung cancer in patients over 75 years of age: a multi-institutional study. Interact Cardiovasc Thorac Surg 16(3):250–256

    Article  PubMed  Google Scholar 

  • Dell′Amore A et al (2014) Lobar and sublobar lung resection in octogenarians with early stage non-small cell lung cancer: factors affecting surgical outcomes and long-term results. Gen Thorac Cardiovasc Surg 63(4):222-230

    Article  PubMed  Google Scholar 

  • Goldstraw P et al (2007) The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol 2(8):706–714

    Article  PubMed  Google Scholar 

  • Guerra M, Neves P, Miranda J (2013) Surgical treatment of non-small-cell lung cancer in octogenarians. Interact Cardiovasc Thorac Surg 16(5):673–680

    Article  PubMed  PubMed Central  Google Scholar 

  • Gulbins E, Steinhausen M (2003) Medizinische Physiologie. 5. Auflage, Ecomed, Landsberg

    Google Scholar 

  • Harada H et al (2013) Multidisciplinary team-based approach for comprehensive preoperative pulmonary rehabilitation including intensive nutritional support for lung cancer patients. PLoS One 8(3):e59566

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hino H et al (2015) Results of Lung Cancer Surgery for Octogenarians. Ann Thorac Cardiovasc Surg 21(3):209-216

    Article  PubMed  Google Scholar 

  • Huber RM (2011) Manual Tumore der Lunge und des Mediastinums. Zuckschwerdt, München

    Google Scholar 

  • Ishida T et al (1996) Thoracoscopic limited resection of bronchogenic carcinoma in patients over the age of 80. Int Surg 81(3):237–240

    CAS  PubMed  Google Scholar 

  • Jemal A et al (2011) Global cancer statistics. CA Cancer J Clin 61(2): 69–90

    Article  PubMed  Google Scholar 

  • Kerstjens HA et al (1997) Decline of FEV1 by age and smoking status: facts, figures, and fallacies. Thorax 52(9):820–827

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kohler BA et al (2011) Annual report to the nation on the status of cancer, 1975–2007, featuring tumors of the brain and other nervous system. J Natl Cancer Inst 103(9):714–736

    Google Scholar 

  • Lee JG et al (2011) Thoracoscopic lobectomy is associated with superior compliance with adjuvant chemotherapy in lung cancer. Ann Thorac Surg 91(2):344–348

    Article  PubMed  Google Scholar 

  • Li XC et al (2015) Different limited resection of pulmonary lobe methods under the thoracoscopy in the treatment of early nonsmall cell lung cancer occurred in the old age. Indian J Cancer 51 Suppl 2:e29–32

    Google Scholar 

  • Liu, HC et al (2013) Surgery for elderly lung cancer. Ann Thorac Cardiovasc Surg 19(6):416–422

    Article  PubMed  Google Scholar 

  • McKenna RJ Jr (1994) Thoracoscopic lobectomy with mediastinal sampling in 80-year-old patients. Chest 106(6):1902–1904

    Article  PubMed  Google Scholar 

  • Morandi U et al (1997)Results of surgical resection in patients over the age of 70 years with non small-cell lung cancer. Eur J Cardiothorac Surg 11(3):432–439

    Article  CAS  PubMed  Google Scholar 

  • Nakamura M et al (2002) [Criteria of impairment of pulmonary function using Japanese standard values]. Nihon Kokyuki Gakkai Zasshi 40(12):925–928

    PubMed  Google Scholar 

  • Nana-Sinkam SP, Powell CA (2013) Molecular biology of lung cancer: Diagnosis and management of lung cancer, 3. Auflage, American College of Chest Physicians evidence-based clinical practice guidelines. Chest 143(5 Suppl): e30S–9S

    Google Scholar 

  • Neves PC et al (2012) Surgical treatment of non-small cell lung cancer in octogenarians – safety and prognosis. Rev Port Cir Cardiotorac Vasc 19(2):63–67

    PubMed  Google Scholar 

  • Nicastri, DG et al (2008) Thoracoscopic lobectomy: report on safety, discharge independence, pain, and chemotherapy tolerance. J Thorac Cardiovasc Surg 135(3):642–647

    Google Scholar 

  • Oczenski W, Werba A, Andel H (2000) Atmen – Atemhilfen – Atemphysiologie und Beatmungstechnik. Wien: Blackwell Wissenschaftsverlag

    Google Scholar 

  • Okada A, Hirono T, Watanabe T (2012) Safety and prognosis of limited surgery for octogenarians with non-small-cell lung cancer. Gen Thorac Cardiovasc Surg 60(2):97–103

    Article  PubMed  Google Scholar 

  • Pallis AG, Scarci M (2011) Are we treating enough elderly patients with early stage non-small cell lung cancer? Lung Cancer 74(2):149–154

    Article  CAS  PubMed  Google Scholar 

  • Patterson GA et al (2008) Pearson´s thoracic and esophageal surgery. 3. Auflage, Livingston, Philadelphia

    Google Scholar 

  • Port JL et al (2011) Lobectomy in octogenarians with non-small cell lung cancer: ramifications of increasing life expectancy and the benefits of minimally invasive surgery. Ann Thorac Surg 92(6):1951–1957

    Article  PubMed  Google Scholar 

  • Rivera C et al (2012) Are postoperative consequences of neoadjuvant chemotherapy for non-small cell lung cancer more severe in elderly patients? Lung Cancer 76(2):216–221

    Article  PubMed  Google Scholar 

  • Robert Koch-Institut (2013) Krebs in Deutschland 2009/2010. 9. Auflage, Berlin

    Google Scholar 

  • Rostad H et al (2005) Results of pulmonary resection for lung cancer in Norway, patients older than 70 years. Eur J Cardiothorac Surg 27(2):325–328

    Article  PubMed  Google Scholar 

  • Schuchert MJ et al (2012) Influence of age and IB status after resection of node-negative non-small cell lung cancer. Ann Thorac Surg 93(3):929–35; discussion 935–936

    Article  PubMed  Google Scholar 

  • Shaw AT et al (2014) Crizotinib in ROS1-rearranged non-small-cell lung cancer. N Engl J Med 371(21):1963–1971

    Article  PubMed  PubMed Central  Google Scholar 

  • Srisomboon C et al (2013) Thoracoscopic surgery for non-small-cell lung cancer: elderly vs. octogenarians. Asian Cardiovasc Thorac Ann 21(1):56–60

    Article  PubMed  Google Scholar 

  • Suemitsu R et al (2009) The perioperative complications for elderly patients with lung cancer associated with a pulmonary resection under general anesthesia. J Thorac Oncol 4(2):193–197

    Article  PubMed  Google Scholar 

  • Tosato F et al (2001) [Lung surgery in the elderly]. Minerva Chir 56(4):393–397

    CAS  Google Scholar 

  • Travis WD (2011) Pathology of lung cancer. Clin Chest Med 32(4):669–92

    Article  PubMed  Google Scholar 

  • Wang Y et al (2015) Is radical mediastinal lymphadenectomy necessary for elderly patients with clinical N-negative non-small-cell lung cancer? A single center matched-pair study. J Surg Res 193(1):435–441

    Article  PubMed  Google Scholar 

  • Wang Z et al (2014) Factors affecting major morbidity after video-assisted thoracic surgery for lung cancer. J Surg Res 192(2):628–634

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Palade, E., Kirschbaum, A. (2016). Chirurgie von primären Lungentumoren bei alten Patienten. In: Keck, T., Hopt, U. (eds) Onkologische Chirurgie bei alten Patienten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48712-9_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-48712-9_21

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-48711-2

  • Online ISBN: 978-3-662-48712-9

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics